scholarly journals In Vitro Evaluation of Reversible and Time-Dependent Inhibitory Effects of Kalanchoe crenata on CYP2C19 and CYP3A4 Activities

2015 ◽  
Vol 9 (1) ◽  
pp. 48-62 ◽  
Author(s):  
Charles Awortwe ◽  
Vamshi Manda ◽  
Cristina Avonto ◽  
Shabana Khan ◽  
Ikhlas Khan ◽  
...  
2014 ◽  
Vol 2 (4) ◽  
pp. 33-35
Author(s):  
Soroor Erfanimanesh ◽  
Gita Eslami ◽  
Hossein Goudarzi ◽  
Arezou Taherpour ◽  
Ali Hashemi ◽  
...  

2005 ◽  
Vol 5 (4) ◽  
pp. S180-S181
Author(s):  
Hyun Bae ◽  
Li Zhao ◽  
Pamela Wong ◽  
Ben Pradhan ◽  
Michael Kropf ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Masaaki Minami ◽  
Toru Konishi ◽  
Hiroshi Takase ◽  
Toshiaki Makino

Streptococcus pneumoniae (S. pneumoniae) is the important pathogen that causes otolaryngeal diseases such as sinusitis. S. pneumoniae frequently forms the biofilm to prevent severe circumstances such as antimicrobial agents. Shin’iseihaito (xinyiqingfeitang) is a formula of Japanese traditional Kampo medicine that has 9 crude drugs and provides the medicinal usage for sinusitis. The objective of the present study is to reveal the mechanism of antibiofilm activity by Shin’iseihaito extract (SSHT). SSHT significantly inhibited the formation of biofilm from S. pneumoniae ATCC 49619 in dose- and time-dependent manners. SSHT also significantly suppressed the biofilm formation by other five different cps types of S. pneumoniae clinical isolates. We found that the extracts of 8 out of 9 components in Shin’iseihaito had the inhibitory effects of biofilm formation, and the extract of the root of Scutellaria baicalensis had the strongest effect among the ingredients of Shin’iseihaito. We found that the capsule of SSHT-treated S. pneumoniae was significantly thinner than that of the untreated group and that SSHT reduced the hydrophobicity of bacterial cell surface. Our results suggest that Shin’iseihaito may be a useful agent for the treatment of S. pneumoniae-induced sinusitis because of the inhibition of biofilm formation of S. pneumoniae.


2015 ◽  
Vol 46 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Siriwan Charyasriwong ◽  
Ken Watanabe ◽  
Ratika Rahmasari ◽  
Ayaka Matsunaga ◽  
Takahiro Haruyama ◽  
...  

2019 ◽  
Vol 14 (6) ◽  
pp. 971 ◽  
Author(s):  
Magdalena Kondeva-Burdina ◽  
Maya Georgieva ◽  
Alexandra Kasabova-Angelova ◽  
Virginia Tzankova ◽  
Alexander Zlatkov

2010 ◽  
Vol 38 (12) ◽  
pp. 2173-2178 ◽  
Author(s):  
Tatsuki Fukami ◽  
Shiori Takahashi ◽  
Nao Nakagawa ◽  
Taiga Maruichi ◽  
Miki Nakajima ◽  
...  

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