Prominence of Oxidative Stress in the Management of Anti-tuberculosis Drugs Related Hepatotoxicity

2020 ◽  
Vol 13 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Preena John ◽  
Pravin P. Kale
Keyword(s):  
Oxidative Stress ◽  
Membrane Permeability ◽  
Signaling Pathway ◽  
Critical Condition ◽  
Permeability Transition ◽  
Review Article ◽  
Present Review ◽  
Membrane Permeability Transition ◽  
Hepatic Glutathione

: Advanced medical services and treatments are available for treating Tuberculosis. Related prevalence has increased in recent times. Unfortunately, the continuous consumption of related drugs is also known for inducing hepatotoxicity which is a critical condition and cannot be overlooked. The present review article has focused on the pathways causing these toxicities and also the role of enzyme CYP2E1, hepatic glutathione, Nrf2-ARE signaling pathway, and Membrane Permeability Transition as possible targets which may help in preventing the hepatotoxicity induced by the drugs used in the treatment of tuberculosis.

Role of Neuroimaging Modality in the Assessment of Oxidative Stress in Brain: A Comprehensive Review

2019 ◽  
Vol 18 (5) ◽  
pp. 372-381 ◽  
Author(s):  
Vikas Pareek ◽  
Banshi Nath ◽  
Prasun K. Roy
Keyword(s):  
Oxidative Stress ◽  
Diffusion Tensor ◽  
Apoptotic Cell ◽  
Review Article ◽  
Present Review ◽  
Resonance Spectroscopy ◽  
Secondary Source ◽  
Longitudinal Assessment ◽  
Induced Changes

Background & Objective:Oxidative stress (OS) is the secondary source of an injury in consequence to the earlier caused primary injury; it is the condition of an imbalance between oxidants and antioxidants within the physiological system. OS causes alterations in proteins and DNA structure, leading to inflammation, apoptotic cell death, and tissue damage. Neurodegenerative diseases (NDDs) such as Alzheimer's disease, Parkinson's disease, Glioma-induced neurodegeneration and the normal aging-related neuro-degeneration are primarily associated with the increased OS. The present review article is committed to delivering a comprehensive overview of the current neuroimaging modalities which estimates an indirect correlate of OS in the brain. OS-induced changes in white matter tracts and the gray matter volumes are reviewed assessing the role of diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) respectively. Further, the role of magnetic resonance spectroscopy (MRS) to assess the OS-induced alterations of chemical moieties, and thus the resultant structural implications in the neurological disorders are also briefly as well as precisely reviewed.Conclusions:In the present review article we present an overview of the role of neuroimaging modalities in the diagnosis, and longitudinal assessment during treatment of the OS induced changes.

ROLE OF L-CARNITINE IN MEMBRANE PERMEABILITY TRANSITION AND APOPTOSIS

2000 ◽  
Vol 28 (5) ◽  
pp. A441-A441
Author(s):  
Kozo Utsimil ◽  
Tomoko Kanno ◽  
Toshlhlko Utsumr ◽  
Takashi Furuno ◽  
Tamotsu Yoshloka ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Permeability Transition ◽  
Membrane Permeability Transition

scholarly journals Role of α-Tocopherol in the Regulation of Mitochondrial Membrane Permeability Transition

2004 ◽  
Vol 35 (1) ◽  
pp. 7-15
Author(s):  
Tomoko Kanno ◽  
Masae Yorimitsu ◽  
Shikibu Muranaka ◽  
Eisuke F. Sato ◽  
Makoto Nagano ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Mitochondrial Membrane ◽  
Permeability Transition ◽  
Mitochondrial Membrane Permeability ◽  
Membrane Permeability Transition
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