Sex Differences in Gamma Band Functional Connectivity Between the Frontal Lobe and Cortical Areas During an Auditory Oddball Task, as Revealed by Imaginary Coherence Assessment

We studied sex-related differences in gamma oscillation during an auditory oddball task, using magnetoencephalography and electroencephalography assessment of imaginary coherence (IC). We obtained a statistical source map of event-related desynchronization (ERD) / event-related synchronization (ERS), and compared females and males regarding ERD / ERS. Based on the results, we chose respectively seed regions for IC determinations in low (30-50 Hz), mid (50-100 Hz) and high gamma (100-150 Hz) bands. In males, ERD was increased in the left posterior cingulate cortex (CGp) at 500 ms in the low gamma band, and in the right caudal anterior cingulate cortex (cACC) at 125 ms in the mid-gamma band. ERS was increased in the left rostral anterior cingulate cortex (rACC) at 375 ms in the high gamma band. We chose the CGp, cACC and rACC as seeds, and examined IC between the seed and certain target regions using the IC map. IC changes depended on the height of the gamma frequency and the time window in the gamma band. Although IC in the mid and high gamma bands did not show sex-specific differences, IC at 30-50 Hz in males was increased between the left rACC and the frontal, orbitofrontal, inferior temporal and fusiform target regions. Increased IC in males suggested that males may acomplish the task constructively, analysingly, emotionally, and by perfoming analysis, and that information processing was more complicated in the cortico-cortical circuit. On the other hand, females showed few differences in IC. Females planned the task with general attention and economical well-balanced processing, which was explained by the higher overall functional cortical connectivity. CGp, cACC and rACC were involved in sex differences in information processing and were likely related to differences in neuroanatomy, hormones and neurotransmitter systems.

Download Full-text

Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model

Molecular Brain ◽

10.1186/s13041-020-00670-w ◽

2020 ◽

Vol 13 (1) ◽

Author(s):

Isabel D. Friesner ◽

Erik Martinez ◽

Haocheng Zhou ◽

Jonathan Douglas Gould ◽

Anna Li ◽

...

Keyword(s):

Chronic Pain ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Affective Responses ◽

Gamma Band ◽

Anterior Cingulate ◽

Band Power ◽

Before And After ◽

High Gamma ◽

Gamma Power

Abstract Chronic pain alters cortical and subcortical plasticity, causing enhanced sensory and affective responses to peripheral nociceptive inputs. Previous studies have shown that ketamine had the potential to inhibit abnormally amplified affective responses of single neurons by suppressing hyperactivity in the anterior cingulate cortex (ACC). However, the mechanism of this enduring effect has yet to be understood at the network level. In this study, we recorded local field potentials from the ACC of freely moving rats. Animals were injected with complete Freund’s adjuvant (CFA) to induce persistent inflammatory pain. Mechanical stimulations were administered to the hind paw before and after CFA administration. We found a significant increase in the high-gamma band (60–100 Hz) power in response to evoked pain after CFA treatment. Ketamine, however, reduced the high-gamma band power in response to evoked pain in CFA-treated rats. In addition, ketamine had a sustained effect on the high-gamma band power lasting up to five days after a single dose administration. These results demonstrate that ketamine has the potential to alter maladaptive neural responses in the ACC induced by chronic pain.

Download Full-text

Increased fMRI activation of anterior cingulate to infrequent compared to frequent stimuli in an auditory oddball task

PsycEXTRA Dataset ◽

10.1037/e526132012-233 ◽

1996 ◽

Author(s):

Vinod Menon ◽

Kelvin O. Lim ◽

Judith M. Ford ◽

Adolf Pfefferbaum

Keyword(s):

Anterior Cingulate ◽

Auditory Oddball ◽

Oddball Task ◽

Auditory Oddball Task

Download Full-text

Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia

Schizophrenia Research ◽

10.1016/j.schres.2018.07.010 ◽

2018 ◽

Vol 202 ◽

pp. 188-194 ◽

Cited By ~ 1

Author(s):

Sinead M. O'Donovan ◽

Ana Franco-Villanueva ◽

Valentina Ghisays ◽

Jody L. Caldwell ◽

Vahraim Haroutunian ◽

...

Keyword(s):

Sex Differences ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Dementia Severity

Download Full-text

Resting-state theta oscillations and reward sensitivity in risk taking

10.1101/2021.02.23.432425 ◽

2021 ◽

Author(s):

Maria Azanova ◽

Maria Herrojo Ruiz ◽

Alexis V. Belianin ◽

Vasily Klucharev ◽

Vadim V. Nikulin

Keyword(s):

Sex Differences ◽

Anterior Cingulate Cortex ◽

Risk Taking ◽

Resting State ◽

Cingulate Cortex ◽

Reward Sensitivity ◽

Anterior Cingulate ◽

Theta Oscillations ◽

Theta Power ◽

Reward And Punishment

AbstractFemales demonstrate greater risk aversion than males on a variety of tasks, but the underlying neurobiological basis is still unclear. We studied how theta (4-7 Hz) oscillations at rest related to three different measures of risk taking. Thirty-five participants (15 females) completed the Bomb Risk Elicitation Task (BRET), which allowed us to measure risk taking during an economic game. The Domain-Specific Risk-Taking Scale (DOSPERT) was used to measure self-assessed risk attitudes as well as reward and punishment sensitivities. In addition, the Barratt Impulsiveness Scale (BIS11) was included to quantify impulsiveness. To obtain measures of frontal theta asymmetry and frontal theta power, we used magnetoencephalography (MEG) acquired prior to task completion, while participants were at rest. Frontal theta asymmetry correlated with average risk taking during the game but only in the female sample. By contrast, frontal theta power correlated with risk taking as well as with measures of reward and punishment sensitivity in the joint sample. Importantly, we showed that reward sensitivity mediated a correlation between risk taking and the power of theta oscillations localized to the anterior cingulate cortex. In addition, we observed significant sex differences in source- and sensor-space theta power, risk taking during the game, and reward sensitivity. Our findings suggest that sensitivity to rewards, associated with resting-state theta oscillations in the anterior cingulate cortex, is a trait that potentially contributes to sex differences in risk taking.

Download Full-text