Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia

AbstractFemales demonstrate greater risk aversion than males on a variety of tasks, but the underlying neurobiological basis is still unclear. We studied how theta (4-7 Hz) oscillations at rest related to three different measures of risk taking. Thirty-five participants (15 females) completed the Bomb Risk Elicitation Task (BRET), which allowed us to measure risk taking during an economic game. The Domain-Specific Risk-Taking Scale (DOSPERT) was used to measure self-assessed risk attitudes as well as reward and punishment sensitivities. In addition, the Barratt Impulsiveness Scale (BIS11) was included to quantify impulsiveness. To obtain measures of frontal theta asymmetry and frontal theta power, we used magnetoencephalography (MEG) acquired prior to task completion, while participants were at rest. Frontal theta asymmetry correlated with average risk taking during the game but only in the female sample. By contrast, frontal theta power correlated with risk taking as well as with measures of reward and punishment sensitivity in the joint sample. Importantly, we showed that reward sensitivity mediated a correlation between risk taking and the power of theta oscillations localized to the anterior cingulate cortex. In addition, we observed significant sex differences in source- and sensor-space theta power, risk taking during the game, and reward sensitivity. Our findings suggest that sensitivity to rewards, associated with resting-state theta oscillations in the anterior cingulate cortex, is a trait that potentially contributes to sex differences in risk taking.

Download Full-text

Sex differences in anterior cingulate cortex activation during impulse inhibition and behavioral correlates

Psychiatry Research Neuroimaging ◽

10.1016/j.pscychresns.2011.05.008 ◽

2012 ◽

Vol 201 (1) ◽

pp. 54-62 ◽

Cited By ~ 42

Author(s):

Jing Liu ◽

Jon-Kar Zubieta ◽

Mary Heitzeg

Keyword(s):

Sex Differences ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Behavioral Correlates

Download Full-text

Sex differences in connectivity of the subgenual anterior cingulate cortex

Pain ◽

10.1016/j.pain.2014.01.005 ◽

2014 ◽

Vol 155 (4) ◽

pp. 755-763 ◽

Cited By ~ 41

Author(s):

Gang Wang ◽

Nathalie Erpelding ◽

Karen D. Davis

Keyword(s):

Sex Differences ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Subgenual Anterior Cingulate Cortex

Download Full-text

Sex Differences in Gamma Band Functional Connectivity Between the Frontal Lobe and Cortical Areas During an Auditory Oddball Task, as Revealed by Imaginary Coherence Assessment

The Open Neuroimaging Journal ◽

10.2174/1874440001610010085 ◽

2016 ◽

Vol 10 (1) ◽

pp. 85-101 ◽

Cited By ~ 1

Author(s):

Toshiro Fujimoto ◽

Eiichi Okumura ◽

Atsushi Kodabashi ◽

Kouzou Takeuchi ◽

Toshiaki Otsubo ◽

...

Keyword(s):

Sex Differences ◽

Information Processing ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Gamma Band ◽

Anterior Cingulate ◽

Auditory Oddball ◽

Oddball Task ◽

High Gamma ◽

Auditory Oddball Task

We studied sex-related differences in gamma oscillation during an auditory oddball task, using magnetoencephalography and electroencephalography assessment of imaginary coherence (IC). We obtained a statistical source map of event-related desynchronization (ERD) / event-related synchronization (ERS), and compared females and males regarding ERD / ERS. Based on the results, we chose respectively seed regions for IC determinations in low (30-50 Hz), mid (50-100 Hz) and high gamma (100-150 Hz) bands. In males, ERD was increased in the left posterior cingulate cortex (CGp) at 500 ms in the low gamma band, and in the right caudal anterior cingulate cortex (cACC) at 125 ms in the mid-gamma band. ERS was increased in the left rostral anterior cingulate cortex (rACC) at 375 ms in the high gamma band. We chose the CGp, cACC and rACC as seeds, and examined IC between the seed and certain target regions using the IC map. IC changes depended on the height of the gamma frequency and the time window in the gamma band. Although IC in the mid and high gamma bands did not show sex-specific differences, IC at 30-50 Hz in males was increased between the left rACC and the frontal, orbitofrontal, inferior temporal and fusiform target regions. Increased IC in males suggested that males may acomplish the task constructively, analysingly, emotionally, and by perfoming analysis, and that information processing was more complicated in the cortico-cortical circuit. On the other hand, females showed few differences in IC. Females planned the task with general attention and economical well-balanced processing, which was explained by the higher overall functional cortical connectivity. CGp, cACC and rACC were involved in sex differences in information processing and were likely related to differences in neuroanatomy, hormones and neurotransmitter systems.

Download Full-text

Sex differences in GABAergic gene expression occur in the anterior cingulate cortex in schizophrenia

Schizophrenia Research ◽

10.1016/j.schres.2015.01.025 ◽

2015 ◽

Vol 167 (1-3) ◽

pp. 57-63 ◽

Cited By ~ 10

Author(s):

Greg C. Bristow ◽

John A. Bostrom ◽

Vahram Haroutunian ◽

Monsheel S. Sodhi

Keyword(s):

Gene Expression ◽

Sex Differences ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate

Download Full-text

Resting-State Theta Oscillations and Reward Sensitivity in Risk Taking

Frontiers in Neuroscience ◽

10.3389/fnins.2021.608699 ◽

2021 ◽

Vol 15 ◽

Author(s):

Maria Azanova ◽

Maria Herrojo Ruiz ◽

Alexis V. Belianin ◽

Vasily Klucharev ◽

Vadim V. Nikulin

Keyword(s):

Sex Differences ◽

Anterior Cingulate Cortex ◽

Risk Taking ◽

Resting State ◽

Cingulate Cortex ◽

Reward Sensitivity ◽

Anterior Cingulate ◽

Theta Oscillations ◽

Theta Power ◽

Reward And Punishment

Females demonstrate greater risk aversion than males on a variety of tasks, but the underlying neurobiological basis is still unclear. We studied how theta (4–7 Hz) oscillations at rest related to three different measures of risk taking. Thirty-five participants (15 females) completed the Bomb Risk Elicitation Task (BRET), which allowed us to measure risk taking during an economic game. The Domain-Specific Risk-Taking Scale (DOSPERT) was used to measure self-assessed risk attitudes as well as reward and punishment sensitivities. In addition, the Barratt Impulsiveness Scale (BIS11) was included to quantify impulsiveness. To obtain measures of frontal theta asymmetry and frontal theta power, we used magnetoencephalography (MEG) acquired prior to task completion, while participants were at rest. Frontal theta asymmetry correlated with average risk taking during the game but only in the female sample. By contrast, frontal theta power correlated with risk taking as well as with measures of reward and punishment sensitivity in the joint sample. Importantly, we showed that reward sensitivity mediated a correlation between risk taking and the power of theta oscillations localized to the anterior cingulate cortex. In addition, we observed significant sex differences in source- and sensor-space theta power, risk taking during the game, and reward sensitivity. Our findings suggest that sensitivity to rewards, associated with resting-state theta oscillations in the anterior cingulate cortex, is a trait that potentially contributes to sex differences in risk taking.

Download Full-text

Sex differences in distributed error-related neural activation in binge drinking young adults

10.31234/osf.io/x4yj3 ◽

2021 ◽

Author(s):

Jillian E Hardee ◽

Alexander Samuel Weigard ◽

Mary Heitzeg ◽

Meghan E. Martz ◽

Lora M. Cope

Keyword(s):

Substance Use ◽

Sex Differences ◽

Cognitive Control ◽

Binge Drinking ◽

Anterior Cingulate Cortex ◽

Linear Regression Analysis ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Neural Activation ◽

Summary Measure

Detecting and responding to errors is central to goal-directed behavior and cognitive control, which are thought to be supported by a network of structures that includes the anterior cingulate cortex and anterior insula. Notable sex differences in the maturational timing of cognitive control neural systems create differential periods of vulnerability for psychiatric conditions, such as substance use disorders, between males and females. Here we examined sex differences in error-related activation across an array of distributed brain regions during a go/no-go task in a sample of binge drinking college students. Regions of interest previously linked to error-related activation, including the anterior cingulate cortex, insula, and frontoparietal structures, were selected in a term-based meta-analysis and individual differences in their activation were indexed using a multivariate summary measure. Males exhibited significantly higher levels of this multivariate summary measure than females. Males also reported significantly greater substance use; however, substance use did not significantly predict neural activation in a linear regression analysis. These findings suggest that males have more marked responses to errors across a network of regions linked to performance monitoring and cognitive control.

Download Full-text