scholarly journals Effect of Edaravone, a Free Radical Scavenger, on Ischemic Cerebral Edema Assessed by Magnetic Resonance Imaging

2007 ◽  
Vol 47 (5) ◽  
pp. 197-202 ◽  
Author(s):  
Satoshi SUDA ◽  
Hironaka IGARASHI ◽  
Yasushi ARAI ◽  
Jyun ANDOU ◽  
Tetsuro CHISHIKI ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Free Radical ◽  
Magnetic Resonance ◽  
Cerebral Edema ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Resonance Imaging

Magnetic resonance imaging of cerebral edema during experimental pneumococcal meningitis

2008 ◽  
Vol 25 (Sup 44) ◽  
pp. 95
Author(s):  
M. Pedersen ◽  
L. Søgard ◽  
G. Knudsen ◽  
P. Skinhøj ◽  
K. Møller
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cerebral Edema ◽  
Pneumococcal Meningitis ◽  
Resonance Imaging ◽  
Experimental Pneumococcal Meningitis

Free radical imaging of endogenous redox molecules using dynamic nuclear polarisation magnetic resonance imaging

2020 ◽  
pp. 1-9
Author(s):  
Fuminori Hyodo ◽  
Shinji Ito ◽  
Hinako Eto ◽  
Abdelazim Elsayed Elhelaly ◽  
Masaharu Murata ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Free Radical ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Dynamic Nuclear Polarisation ◽  
Nuclear Polarisation ◽  
Redox Molecules

scholarly journals The challenge of neuroimaging during pregnancy

2019 ◽  
Vol 8 (11) ◽  
pp. 4376
Author(s):  
Kariman Suel Ghazal ◽  
Abdul Rahman Shatila
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Cerebral Edema ◽  
Neurological Disorders ◽  
Resonance Imaging ◽  
Female Reproduction ◽  
Cerebellar Hemorrhage ◽  
Neurologic Disorders

Background: Central nervous system conditions may affect every aspect of female reproduction from fertility to lactation. The objective of this study was to examine the performance of computed tomography and magnetic resonance imaging in the diagnosis of maternal neurologic disorders and to examine the outcome of pregnancies complicated by abnormal neurologic imaging.Methods: Retrospective observational study of 20 parturients presenting with severe neurologic symptoms (January 2006 to January 2016).Results: Abnormal neuro-radiological findings were found. Only 10% of the computed tomography-scans were normal. Both magnetic resonance imaging and computed tomography that were performed in all cases showed cerebral edema (90%) with different degrees, thereby cerebral edema was the predominant lesion. Pertaining to its localization, 65% were localized in the parietal or occipital area, 10% in the paraventricular area, and 10% were diffused. Also, 35% showed intracerebral hemorrhage and 10% showed cerebellar hemorrhage. The incidence of neurological disorders in pregnancy and puerperium was high. Epilepsy and headache were the most common primary and secondary neurological disorders.Conclusions: The role of neuroimaging in diagnosing neurological disorders is crucial for prevention of severe complications.

High-altitude cerebral edema evaluated with magnetic resonance imaging

1999 ◽  
Vol 11 (2) ◽  
pp. 134
Author(s):  
P H Hackett ◽  
P R Yarnell ◽  
R Hill ◽  
K Reynard ◽  
J Heit ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Altitude ◽  
Cerebral Edema ◽  
Resonance Imaging ◽  
High Altitude Cerebral Edema

scholarly journals Magnetic Resonance Imaging Evidence of Cytotoxic Cerebral Edema in Acute Mountain Sickness

2006 ◽  
Vol 27 (5) ◽  
pp. 1064-1071 ◽  
Author(s):  
Kai Kallenberg ◽  
Damian M Bailey ◽  
Stefan Christ ◽  
Alexander Mohr ◽  
Robin Roukens ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cerebral Edema ◽  
Acute Mountain Sickness ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Evidence ◽  
Mountain Sickness

scholarly journals An Electronic Aerosol Delivery System for Functional Magnetic Resonance Imaging

2020 ◽  
Vol 14 ◽  
pp. 117822182090414
Author(s):  
Andréa L Hobkirk ◽  
Zachary Bitzer ◽  
Reema Goel ◽  
Christopher T Sica ◽  
Craig Livelsberger ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Free Radical ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Free Radical Production ◽  
Nicotine Concentration ◽  
Radical Production ◽  
Addictive Potential ◽  
Nicotine Yield

Background: Public health concerns over the addictive potential of electronic cigarettes (e-cigs) have heightened in recent years. Brain function during e-cig use could provide an objective measure of the addictive potential of new vaping products to facilitate research; however, there are limited methods for delivering e-cig aerosols during functional magnetic resonance imaging (fMRI). The current study describes the development and feasibility testing of a prototype to deliver up to four different e-cig aerosols during fMRI. Methods: Standardized methods were used to test the devices’ air flow variability, nicotine yield, and free radical production. MRI scans were run with and without the device present to assess its safety and effects on MRI data quality. Five daily smokers were recruited to assess plasma nicotine absorption from e-liquids containing nicotine concentrations of 8, 11, 16, 24, and 36 mg/ml. Feedback was collected from participants through a semi-structured interview and computerized questionnaire to assess comfort and subjective experiences of inhaling aerosol from the device. Results: Nicotine yield captured from the aerosol produced by the device was highly correlated with the nicotine concentration of the e-liquids used (R2 = 0.965). Nicotine yield was reduced by a mean of 48% and free radical production by 17% after traveling through the device. The e-liquid containing the highest nicotine concentration tested (36 mg/ml) resulted in the highest plasma nicotine boost (6.6 ng/ml). Overall, participants reported that the device was comfortable to use and inhaling the e-cig aerosols was tolerable. The device was determined to be safe for use during fMRI and had insignificant effects on scan quality. Conclusions: With the current project, we were able to design a working prototype that safely and effectively delivers e-cig aerosols during fMRI. The device has the potential to be used to assess brain activation during e-cig use and to compare brain reactivity to varying flavors, nicotine concentrations, and other e-cig characteristics.

scholarly journals Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke

2016 ◽  
Vol 37 (2) ◽  
pp. 550-563 ◽  
Author(s):  
Hanshu Zhao ◽  
Rachel Nepomuceno ◽  
Xin Gao ◽  
Lesley M Foley ◽  
Shaoxia Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ischemic Stroke ◽  
Magnetic Resonance ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Cerebral Edema ◽  
Artery Occlusion ◽  
Wild Type ◽  
Resonance Imaging ◽  
Cerebral Artery Occlusion

The WNK-SPAK kinase signaling pathway controls renal NaCl reabsorption and systemic blood pressure by regulating ion transporters and channels. A WNK3-SPAK complex is highly expressed in brain, but its function in this organ remains unclear. Here, we investigated the role of this kinase complex in brain edema and white matter injury after ischemic stroke. Wild-type, WNK3 knockout, and SPAK heterozygous or knockout mice underwent transient middle cerebral artery occlusion. One cohort of mice underwent magnetic resonance imaging. Ex-vivo brains three days post-ischemia were imaged by slice-selective spin-echo diffusion tensor imaging magnetic resonance imaging, after which the same brain tissues were subjected to immunofluorescence staining. A second cohort of mice underwent neurological deficit analysis up to 14 days post-transient middle cerebral artery occlusion. Relative to wild-type mice, WNK3 knockout, SPAK heterozygous, and SPAK knockout mice each exhibited a >50% reduction in infarct size and associated cerebral edema, significantly less demyelination, and improved neurological outcomes. We conclude that WNK3-SPAK signaling regulates brain swelling, gray matter injury, and demyelination after ischemic stroke, and that WNK3-SPAK inhibition has therapeutic potential for treating malignant cerebral edema in the setting of middle cerebral artery stroke.

Study of Subclinical Cerebral Edema in Diabetic Ketoacidosis by Magnetic Resonance Imaging T2 Relaxometry and Apparent Diffusion Coefficient Maps

2005 ◽  
Vol 31 (4) ◽  
pp. 345-355 ◽  
Author(s):  
Ramon E. Figueroa ◽  
William H. Hoffman ◽  
Zahir Momin ◽  
Ajay Pancholy ◽  
Gregory G. Passmore ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Coefficient ◽  
Magnetic Resonance ◽  
Apparent Diffusion Coefficient ◽  
Diabetic Ketoacidosis ◽  
Cerebral Edema ◽  
Resonance Imaging ◽  
T2 Relaxometry ◽  
Apparent Diffusion ◽  
Apparent Diffusion Coefficient Maps
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