Evaluation of Chest Radiographic Patterns and Its Relationship with Hematological Parameters in Patients with Pulmonary Tuberculosis in Lagos Metropolis, Nigeria

Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis.

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Assessment of Hematological Parameters in Pulmonary Tuberculosis Patients

Indian Journal of Clinical Biochemistry ◽

10.1007/s12291-015-0535-8 ◽

2015 ◽

Vol 31 (3) ◽

pp. 332-335 ◽

Cited By ~ 10

Author(s):

K. Rohini ◽

M. Surekha Bhat ◽

P. S. Srikumar ◽

A. Mahesh Kumar

Keyword(s):

Pulmonary Tuberculosis ◽

Hematological Parameters ◽

Tuberculosis Patients

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Hematological Abnormalities of Pulmonary Tuberculosis Patients with and without HIV at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-Sectional Study

Tuberculosis Research and Treatment ◽

10.1155/2018/5740951 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Feven Abay ◽

Aregawi Yalew ◽

Agumas Shibabaw ◽

Bamlaku Enawgaw

Keyword(s):

Pulmonary Tuberculosis ◽

Hematological Parameters ◽

Cross Sectional Study ◽

Northwest Ethiopia ◽

Sectional Study ◽

Cross Sectional ◽

Mean Values ◽

Tuberculosis Patients ◽

Hematological Abnormalities ◽

The University

Background. Hematological abnormalities are common in pulmonary tuberculosis (PTB) patients, which is one of the major public health problems worldwide. However, there is paucity of information about the hematological profile of PTB patients with and without HIV in the study area. Therefore, this study aimed to assess hematological abnormalities of pulmonary tuberculosis patients with and without HIV at the University of Gondar Hospital, Northwest Ethiopia. Methods. A comparative cross-sectional study was conducted at the University of Gondar Hospital. Sociodemographic data was collected using a pretested, structured questionnaire. Five milliliters of venous blood sample was collected and divided into a 3 ml EDTA tube for complete blood count with the Cell Dyn 1800 hematological analyzer and a 2 ml citrated tube for erythrocyte sedimentation rate determination. Data were entered into Epi Info version 3.5.3 and then transferred to SPSS 20 for analysis. The independent samples t-test was used to compare the mean values of hematological parameters between PTB patients and PTB-HIV coinfected patients. Result. A total of 100 study subjects (50 PTB and 50 PTB-HIV coinfected) were included with a mean age of 31.3 ± 10.3 years for PTB patients and 32.1 ± 9.2 years for PTB-HIV coinfected patients. In this study, there were significantly lower mean values of Hgb (P = 0.049), platelet count (P < 0.001), and neutrophils counts (P = 0.007) among PTB-HIV coinfected patients when compared with PTB patients. Of the PTB infected patients 46% were anemic, 6% leukopenic, 22% neutropenic, 8% lymphopenic, and 8% thrombocytopenic. On the other hand, of the PTB-HIV coinfected patients 60% were anemic, 14% leukopenic, 66% neutropenic, 12% lymphopenic, and 20% thrombocytopenic. ESR value was increased in all patients. Conclusion. This study demonstrated high prevalence of neutropenia, anemia, and thrombocytopenia among PTB-HIV coinfected patients. HIV coinfection worsens hematological abnormalities of PTB patients. Assessment of hematological parameters can be used as an indicator in the diagnosis and follow-up of PTB patients coinfected with HIV. We recommended assessment of PTB patients with or without HIV for various hematological disorders such as neutropenia, anemia, and thrombocytopenia.

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