scholarly journals Pediatric Thoracoscopic Repair of Diaphragmatic Herniation Following Liver Transplantation

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Inês Pessanha ◽  
◽  
Catarina Cunha ◽  
Cláudia Piedade ◽  
Emanuel Furtado ◽  
...  

Diaphragmatic Hernia (DH) after Liver Transplantation (LT) is a rare complication with unclear pathophysiology. Among 261 LT, we recognized six DH during the post transplant period (2.30%). All patients with DH had received a left lateral segment (LLS) reduced graft. The mean graft weight was 340g with a mean graft-to-recipient body weight ratio (GBWR) of 4.20%. LLS grafts, a GBWR > 4%, previous abdominal surgery and direct trauma during surgery can be enumerated as potential risk factors for DH post-LT. These children underwent prompt surgical intervention to DH without complications. Three patients were treated via laparotomy and three by thoracoscopy. No clinical recurrences were accounted at a mean follow up of 5 years. Historically, the treatment has always been surgical repair via laparotomy but the use of minimally invasive techniques in pediatric surgery has been increasing, and the thoracoscopic approach for DH can bring advantages. The patients in which the thoracoscopic approach was used had shorter operative times and a faster recovery with better cosmetic results. As previous surgical manipulation had been done to the abdominal cavity, thoracoscopy seems to be a safe approach in DH in pediatric LT recipients.

2020 ◽  
Vol 24 (8) ◽  
pp. 1869-1879
Author(s):  
Yanhu Feng ◽  
Zhijian Han ◽  
Xiang Wang ◽  
Hao Chen ◽  
Yumin Li

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
Hui Liu ◽  
Chang Chun Ling ◽  
Wai Ho Oscar Yeung ◽  
Li Pang ◽  
Jiang Liu ◽  
...  

AbstractTumor recurrence is the major obstacle for pushing the envelope of liver transplantation for hepatocellular carcinoma (HCC) patients. The inflammatory cascades activated by acute liver graft injury promote tumor recurrence. We aimed to explore the role and mechanism of myeloid-derived suppressor cell (MDSC) mobilization induced by liver graft injury on tumor recurrence. By analyzing 331 HCC patients who received liver transplantation, the patients with graft weight ratio (GWR, the weight of liver graft divided by the estimated standard liver weight of recipient) <60% had higher tumor recurrence than GWR ≥60% ones. MDSCs and CXCL10/TLR4 levels were significantly increased in patients with GWR <60% or tumor recurrence. These findings were further validated in our rat orthotopic liver transplantation model. In CXCL10−/− and TLR4−/− mice of hepatic ischemia/reperfusion injury plus major hepatectomy (IRH) model, monocytic MDSCs, instead of granulocytic MDSCs, were significantly decreased. Importantly, CXCL10 deficiency reduced the accumulation of TLR4+ monocytic MDSCs, and CXCL10 increased MDSC mobilization in the presence of TLR4. Moreover, MMP14 was identified as the key molecule bridging CXCL10/TLR4 signaling and MDSC mobilization. Knockout or inhibition of CXCL10/TLR4 signaling significantly reduced the tumor growth with decreased monocytic MDSCs and MMP14 in the mouse tumor recurrent model. Our data indicated that monocytic MDSCs were mobilized and recruited to liver graft during acute phase injury, and to promote HCC recurrence after transplantation. Targeting MDSC mobilization via CXCL10/TLR4/MMP14 signaling may represent the therapeutic potential in decreasing post-transplant liver tumor recurrence.


2020 ◽  
Vol 24 (4) ◽  
pp. 503-512
Author(s):  
Jung-Man Namgoong ◽  
Shin Hwang ◽  
Gi-Won Song ◽  
Dae-Yeon Kim ◽  
Tae-Yong Ha ◽  
...  

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