scholarly journals Evaluation of a Digital Handheld Hydrogen Breath Monitor to Diagnose Lactose Malabsorption: An Interventional Crossover Study (Preprint)

10.2196/33009 ◽  
2021 ◽  
Author(s):  
Simon C. Mathews ◽  
Sandy Templeton ◽  
Stephanie K. Taylor ◽  
Sten Harris ◽  
Margaret Stewart ◽  
...  
Keyword(s):  
Crossover Study ◽  
Lactose Malabsorption

scholarly journals Evaluation of a Digital Handheld Hydrogen Breath Monitor to Diagnose Lactose Malabsorption: Interventional Crossover Study (Preprint)

2021 ◽  
Author(s):  
Simon C Mathews ◽  
Sandy Templeton ◽  
Stephanie K Taylor ◽  
Sten Harris ◽  
Margaret Stewart ◽  
...  
Keyword(s):  
Crossover Study ◽  
Diagnostic Performance ◽  
Lactose Intolerance ◽  
Gastrointestinal Symptoms ◽  
Common Condition ◽  
Lactose Malabsorption ◽  
Percent Agreement ◽  
Adult Participants ◽  
History Of ◽  
Symptom Recall

BACKGROUND Lactose malabsorption is a common condition that affects a broad segment of the population. Clinical diagnosis based on symptom recall can be unreliable and conventional testing can be inconvenient, requiring expensive laboratory-based equipment and conduction of the testing in a clinical setting. OBJECTIVE The aim of this study is to assess the performance of a digital handheld hydrogen breath monitor (GIMate) in diagnosing lactose malabsorption compared to a US Food and Drug Administration (FDA)–cleared device (H2 Check) for the same indication. METHODS An interventional crossover study was performed in adult participants with a prior confirmed diagnosis of lactose malabsorption or a suspected history of lactose intolerance. RESULTS A total of 31 participants (mean age 33.9 years) were enrolled in the study. There was 100% positive percent agreement and 100% negative percent agreement between the GIMate monitor and the H2 Check. Correlation between gastrointestinal symptoms and hydrogen values was positive at 0.82 (<i>P</i>&lt;.001). CONCLUSIONS The digital handheld GIMate breath monitor achieved equivalent diagnostic performance to that of an FDA-cleared device in the diagnosis of lactose malabsorption. CLINICALTRIAL ClinicalTrials.gov NCT04754724; https://clinicaltrials.gov/ct2/show/NCT04754724

Inhibition of Spontaneous Platelet Aggregation by Sulfinpyrazone

1979 ◽  
Vol 42 (02) ◽  
pp. 621-625 ◽  
Author(s):  
G G Nenci ◽  
G Agnelli ◽  
M Berrettini ◽  
P Parise ◽  
E Ballatori
Keyword(s):  
Platelet Aggregation ◽  
Crossover Study ◽  
Double Blind ◽  
Platelet Aggregability ◽  
Initiation Of Therapy ◽  
Spontaneous Platelet Aggregation ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

SummaryIn a randomized double-blind crossover study in 16 patients with enhanced in vitro spontaneous platelet aggregation, sulfinpyrazone proved to be effective in normalizing platelet aggregability within 4 days after initiation of therapy.

Effect of Stevia on Glycemic and Insulin Responses in Obese Patients—A Randomized, Double-Blind, Placebo-Controlled Crossover Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 790-P
Author(s):  
PARINYA SAMAKKARNTHAI ◽  
MANAPORN PAYANUNDANA ◽  
NATTAPOL SATHAVARODOM ◽  
CHONPITI SIRIWAN ◽  
APUSSANEE BOONYAVARAKUL
Keyword(s):  
Crossover Study ◽  
Obese Patients ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Insulin Responses

755-P: A Plant-Based Meal Stimulates Incretin and Insulin Secretion More than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 755-P
Author(s):  
HANA KAHLEOVA ◽  
ANDREA TURA ◽  
MARTA KLEMENTOVA ◽  
LENKA BELINOVA ◽  
MARTIN HALUZIK ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Crossover Study ◽  
Standard Meal ◽  
Randomized Crossover Study
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