The Use of Repetitive Transcranial Magnetic Stimulation for Treatment of Obsessive-Compulsive Disorder: A Scoping Review. (Preprint)

2021 ◽  
Author(s):  
Medard Adu ◽  
Ejemai Eboreime ◽  
Adegboyega Sapara ◽  
Andrew J. Greenshaw ◽  
Pierre Chue ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Scoping Review ◽  
Magnetic Stimulation ◽  
Depressive Disorders ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Relevant Literature ◽  
Invasive Procedure ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

BACKGROUND Background: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive procedure in which brain neural activity is stimulated by direct application of a magnetic field to the scalp. rTMS is considered a therapeutic tool in various neuropsychiatric conditions. Since its approval in Canada in 2002 and despite its wide and continuous usage for the management of depressive disorders, knowledge on the use of rTMS for Obsessive-Compulsive Disorder (OCD) is sparse. OBJECTIVE Objectives: This scoping review seeks to; (i) explore the relevant literature available regarding the use of rTMS as a mode of treatment for OCD; (ii) To evaluate the evidence to support the use of rTMS as a treatment option for OCD. METHODS Method: We electronically conducted data search in five research databases (MEDLINE, CINAHL, Psych INFO, SCOPUS, and EMBASE) using all identified keywords and index terms across all the data bases to identify empirical studies and randomized controlled trials. We included articles published with randomized control designs which aimed at the treatment of OCD with rTMS. Only full-text published articles written in English were reviewed. Review articles on treatment for conditions other than OCD were excluded. RESULTS NA CONCLUSIONS Conclusion: The application of rTMS as a treatment intervention for OCD looks promising despite diversity in terms of outcomes and clinical significance. Further studies with well-defined stimulation parameters are needed in order to be able to draw a definite conclusion of its clinical effectiveness in the treatment of OCD.

scholarly journals The use of repetitive transcranial magnetic stimulation for treatment of obsessive-compulsive disorder: a scoping review

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Medard Kofi Adu ◽  
Ejemai Eboreime ◽  
Adegboyega Oyekunbi Sapara ◽  
Andrew James Greenshaw ◽  
Pierre Chue ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Scoping Review ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Therapeutic Effects ◽  
Obsessive Compulsive ◽  
Content Type ◽  
Compulsive Disorder ◽  
Data Search

Purpose This paper aims to explore the relevant literature available regarding the use of repetitive transcranial magnetic stimulation (rTMS) as a mode of treatment for obsessive-compulsive disorder (OCD); to evaluate the evidence to support the use of rTMS as a treatment option for OCD. Design/methodology/approach The authors electronically conducted data search in five research databases (MEDLINE, CINAHL, Psych INFO, SCOPUS and EMBASE) using all identified keywords and index terms across all the databases to identify empirical studies and randomized controlled trials. The authors included articles published with randomized control designs, which aimed at the treatment of OCD with rTMS. Only full-text published articles written in English were reviewed. Review articles on treatment for conditions other than OCD were excluded. The Covidence software was used to manage and streamline the review. Findings Despite the inconsistencies in the published literature, the application of rTMS over the supplementary motor area and the orbitofrontal cortex has proven to be promising in efficacy and tolerability compared with other target regions such as the prefrontal cortex for the treatment of OCD. Despite the diversity in terms of the outcomes and clinical variability of the studies under review, rTMS appears to be a promising treatment intervention for OCD. Research limitations/implications The authors of this scoping review acknowledge several limitations. First, the search strategy considered only studies published in English and the results are up to date as the last day of the electronic data search of December 10, 2020. Though every effort was made to identify all relevant studies for the purposes of this review per the eligibility criteria, the authors still may have missed some relevant studies, especially those published in other languages. Originality/value This review brought to bare the varying literature on the application of rTMS and what is considered gaps in the knowledge in this area in an attempt to evaluate and provide information on the potential therapeutic effects of rTMS for OCD.

Dual Target Repetitive Transcranial Magnetic Stimulation In The Treatment Of Comorbid Obsessive-Compulsive Disorder In Patients With Anorexia Nervosa: Preliminary Results Of Two Case Reports

2016 ◽  
Vol 33 (S1) ◽  
pp. S494-S494
Author(s):  
N. De Schryver ◽  
G.M.D. Lemmens ◽  
C. Baeken ◽  
D. Van den Abbeele
Keyword(s):  
Anorexia Nervosa ◽  
Transcranial Magnetic Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
University Hospital ◽  
Hospital Treatment ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

IntroductionObsessive-compulsive disorder (OCD) is a frequently reported comorbid disorder (20–30%) in patients with anorexia nervosa (AN). Increasing evidence suggests that repetitive transcranial magnetic stimulation (r-TMS) may be effective in the treatment of refractory OCD and to a lesser extent in AN. Hereby, different target areas: supplemental motor area (SMA) and orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex in AN. We report two patients with enduring AN and comorbid treatment resistant OCD treated with r-TMS.MethodsBoth female patients (34 and 26 years respectively) were hospitalized at the Eating Disorder Unit at the Ghent University Hospital. Treatment responses were evaluated with Yale Brown Obsessive Compulsive Scale (Y-BOCS) and weight gain. Inhibitory continuous thetaburst stimulation (cTBS) of the SMA followed by cTBS of the OFC was conducted during 20 sessions, 5 sessions a week, during 4 weeks. Stimulation intensity was respectively 100% and 80% of the motor treshold.ResultsAfter cTBS treatment Y-BOCS score of both patients decreased (31 to 24 and 31 to 23 respectively). Only one patient showed a 10% increase of weight. The treatment was well tolerated. No significant side effects were reported.ConclusionTreatment resistant comorbid OCD in patients with AN may be succesfully treated with cTBS.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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