Imaging Features of Fibrolamellar Hepatocellular Carcinoma

2014 ◽  
Vol 202 (3) ◽  
pp. 544-552 ◽  
Author(s):  
Dhakshinamoorthy Ganeshan ◽  
Janio Szklaruk ◽  
Vikas Kundra ◽  
Ahmed Kaseb ◽  
Asif Rashid ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Imaging Features ◽  
Fibrolamellar Hepatocellular Carcinoma

scholarly journals Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Viktoria Palm ◽  
Ruofan Sheng ◽  
Philipp Mayer ◽  
Karl-Heinz Weiss ◽  
Christoph Springfeld ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gadoxetic Acid ◽  
Imaging Features ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
Enhanced Mri

Imaging Features of Fibrolamellar Hepatocellular Carcinoma with Contrast-Enhanced Ultrasound

2020 ◽  
Author(s):  
Yi Dong ◽  
Wen-Ping Wang ◽  
Feng Mao ◽  
Qi Zhang ◽  
Daohui Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Arterial Phase ◽  
Focal Liver Lesions ◽  
European Federation ◽  
Imaging Features ◽  
Contrast Enhanced Ultrasound ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
Central Scar ◽  
Primary Liver Tumor ◽  
Contrast Enhanced

Abstract Purpose Fibrolamellar hepatocellular carcinoma (f-HCC) is a rare primary liver tumor. Imaging plays an important role in diagnosis. The aim of this retrospective study was to analyze contrast-enhanced ultrasound (CEUS) features of histologically proven f-HCC in comparison to benign focal nodular hyperplasia (FNH). Materials & Methods 16 patients with histologically proven f-HCC lesions and 30 patients with FNH lesions were retrospectively reviewed regarding CEUS features to determine the malignant or benign nature of the focal liver lesions (FLL). Five radiologists assessed the CEUS enhancement pattern and came to a consensus using the EFSUMB (European Federation of Societies for Ultrasound in Medicine and Biology) guideline criteria. Results Fibrolamellar hepatocellular carcinoma manifested as a single and huge FLL. On CEUS, f-HCC showed heterogeneous hyperenhancement in the arterial phase and hypoenhancement (16/16, 100 %) in the portal venous and late phases (PVLP) as a sign of malignancy. In contrast to the hypoenhancement of f-HCC in the PVLP, all patients with FNH showed hyperenhancement as the most distinctive feature (P < 0.01). 8 f-HCC lesions showed a central scar as an unenhanced area (8/16, 50.0 %), which could also be detected in 53.3 % (16/30) of FNH lesions (P > 0.05). Conclusion By analyzing the hypoenhancement in the PVLP, CEUS imaging reliably diagnosed f-HCC as a malignant FLL. CEUS also showed differentiation between f-HCC and FNH lesions, showing similar non-enhanced central scars, whereas f-HCC lesions showed peripheral hyperenhancement in the arterial phase and early washout in the PVLP.

Fibrolamellar hepatocellular carcinoma in Mexican patients

2002 ◽  
Vol 8 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Julian Arista-Nasr ◽  
Lisa Gutierrez-Villalobos ◽  
Juan Nuncio ◽  
Hector Maldonaldo ◽  
Leticia Bornstein-Quevedo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
Mexican Patients

scholarly journals Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma

2021 ◽  
Author(s):  
Kotaro Matsumoto ◽  
Kentaro Kikuchi ◽  
Ayako Hara ◽  
Hiromichi Tsunashima ◽  
Koichi Tsuneyama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Histopathological Examination ◽  
Epigastric Pain ◽  
Positive Staining ◽  
C Reactive Protein ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
Tumor Biopsy ◽  
Reactive Protein ◽  
Right Lobe ◽  
The Right

AbstractA 25-year-old woman with fever and epigastric pain was referred to our hospital. Blood examination showed significant liver dysfunction, markedly high C-reactive protein (CRP 19.1 mg/dL) and procalcitonin (48.3 ng/mL) levels. Dynamic computed tomography showed a tumor approximately 120 mm in size in the right lobe of the liver, but with no abscess formation. The patient was hospitalized and started on antibiotics; her CRP level improved, but the procalcitonin level did not decrease. Histopathological examination of the liver tumor biopsy revealed fibrolamellar hepatocellular carcinoma (FLC). Positive staining of the FLC with an anti-procalcitonin antibody suggested the production of procalcitonin.

scholarly journals Imaging of fibrolamellar hepatocellular carcinoma

1988 ◽  
Vol 151 (2) ◽  
pp. 295-299 ◽  
Author(s):  
DJ Brandt ◽  
CD Johnson ◽  
DH Stephens ◽  
LH Weiland
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fibrolamellar Hepatocellular Carcinoma
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