Optoacoustic Breast Imaging: Imaging-Pathology Correlation of Optoacoustic Features in Benign and Malignant Breast Masses

Abstract Background To explore the value of quantitative shear wave elastography (SWE) plus the Breast Imaging Reporting and Data System (BI-RADS) in the identification of solid breast masses. Methods A total of 108 patients with 120 solid breast masses admitted to our hospital from January 2019 to January 2020 were enrolled in this study. The pathological examination served as the gold standard for definitive diagnosis. Both SWE and BI-RADS grading were performed. Results Out of the 120 solid breast masses in 108 patients, 75 benign and 45 malignant masses were pathologically confirmed. The size, shape, margin, internal echo, microcalcification, lateral acoustic shadow, and posterior acoustic enhancement of benign and malignant masses were significantly different (all P < 0.05). The E mean, E max, SD, and E ratio of benign and malignant masses were significantly different (all P < 0.05). The E min was similar between benign and malignant masses (P > 0.05). The percentage of Adler grade II-III of the benign masses was lower than that of the malignant masses (P < 0.05). BI-RADS plus SWE yielded higher diagnostic specificity and positive predictive value than either BI-RADS or SWE; BI-RADS plus SWE yielded the highest diagnostic accuracy among the three methods (all P < 0.05). Conclusion SWE plus routine ultrasonography BI-RADS has a higher value in differentiating benign from malignant breast masses than color doppler or SWE alone, which should be further promoted in clinical practice.

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ROLE OF ULTRASONOGRAPHIC ELASTOGRAPHY IN THE DIFFERENTIAL DIAGNOSIS OF BREAST MASSES AND ITS CONTRIBUTION TO CLASSICAL ULTRASONOGRAPHIC EVALUATION

10.36106/ijsr/0733120 ◽

2021 ◽

pp. 48-50

Author(s):

Ashok Kumar Verma ◽

Rashmi Rashmi ◽

Rakesh Kumar Verma ◽

Mahendra Kumar Pandey

Keyword(s):

Breast Cancer ◽

Breast Imaging ◽

Diagnostic Performance ◽

Breast Biopsy ◽

Strain Ratio ◽

Breast Lesions ◽

Breast Masses ◽

Screening Programs ◽

Imaging Department ◽

Malignant Breast

Introduction: India is experiencing an unprecedented rise in the number of breast cancer cases across all sections of society. Breast cancer is now the most common malignancy in women and the second leading cause of cancer- related mortality. Breast cancer is quite easily and effectively treated, provided it is detected in it's early stages. There is a drastic drop in the survival rates when women present with advanced stage of breast cancer, regardless of the setting. Unfortunately, women in resource-poor and developing countries, like India, generally present at a later stage of disease than women elsewhere, partly due to the absence of effective awareness programs and partly due to the lack of proper mass screening programs Aims And Objectives: The diagnostic performance of elastography in differentiating benign from malignant breast lesions. To assess whether elastography has the potential to reduce the need for breast biopsy /FNAC. Cut off value of Strain Ratio for benign versus malignant breast lesions. Further characterize BI-RADS 3 lesions using elastography Materials And Methods: The study was approved by the GSVM MEDICAL COLLEGE AND LLR HOSPITAL Ethics Committee. All patients that presented to the Radiology and Imaging Department of LLR HOSPITAL for diagnostic work up for breast pathology were included in the study. After obtaining a written and signed informed consent from all patients, they were subjected to conventional B-Mode ultrasonography followed by elastography. All diagnostic breast imaging was done with Samsung RS80A ultrasound machine using linear array transducer of frequency 5-12MHz.Observations & Results: The elastography patterns for each lesion were assessed and documented in color scale. Color images were constructed automatically and displayed as a color-overlay on the B-mode image. The color pattern of each lesion was then evaluated on a scale of 1-5 according to the Tsukuba elasticity scoring system. Conclusion: Strain Ratio cutoff of 3.3 is a sensitive parameter to differentiate benign and malignant breast lesions. Elastography is a specic test for differentiating benign and malignant breast lesions. The combined use of elasticity score, strain ratio and B- Mode sonographyincreases the diagnostic performance in distinguishing benign from malignant breast masses.

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Diagnostic value of various vascular features of breast cancer by age

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-211258 ◽

2021 ◽

pp. 1-9

Author(s):

Jia Lin ◽

Wenqiang Lin ◽

Liang Xu ◽

Teng Lin

Keyword(s):

Breast Cancer ◽

Breast Imaging ◽

Critical Role ◽

Added Value ◽

Breast Lesions ◽

Diagnostic Efficiency ◽

Complex Flow ◽

Diagnostic Efficacy ◽

Breast Masses ◽

Malignant Breast

BACKGROUND: Tumor angiogenesis plays a critical role in the growth and metastasis of breast cancer and evaluating the added value of vascular features to Breast Imaging Reporting and Data System (BI-RADS) in differentiating malignant nodules from benign ones is essential. Micro-flow Imaging (MFI) is a promising noninvasive diagnostic method for the microvessels in breast tumors, but its precise value is still uncertain. OBJECTIVES: Understanding whether malignant tumor vascular characteristics by MFI are associated with breast cancer and whether the diagnostic efficiency varies by age. MATERIALS AND METHODS: We used B-mode Ultrasound and MFI to detect the characteristics of 153 solid breast lesions. Two investigators reviewed the vessels images by MFI and assessed the vascular features, respectively. Evaluating diagnostic efficacy of different vascular features combined with BI-RADS in different age groups. RESULTS: The mean size of lesions is 19.4 (range 18–78) mm. There were 94 breast masses in benign, while 59 breast masses in malignant by pathology. III Adler classification, penetrating vessels, and complex flow pattern showed a positive association with a high risk of malignant breast lesions (p < 0.05). BI-RADS combined with vessel characteristics show better improvement of diagnostic performance of breast lesions in the elderly group than in the young group. CONCLUSIONS: Vascular features by MFI contribute to malignant breast masses’ diagnosis, and the association might be modified by age.

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Comparative sonographic review of benign and malignant breast masses

Journal of Solid Tumors ◽

10.5430/jst.v8n1p42 ◽

2018 ◽

Vol 8 (1) ◽

pp. 42

Author(s):

Afodun A M ◽

Eze E D ◽

Quadri K K ◽

Muhammed A O ◽

Masud M A ◽

...

Keyword(s):

Breast Cancer ◽

Breast Imaging ◽

Scar Tissue ◽

Breast Masses ◽

Ultrasound Findings ◽

Malignant Breast ◽

High Frequency Transducer ◽

Focal Fibrosis ◽

Made In

Complex breast masses may appear as suspicious ultrasound findings that usually warrant biopsy. Ductal cell carcinoma in-situ (DCIS) is a form of breast cancer with a non-uniform appearance and malignant potential. A longitudinal review of mammary gland ultrasound (with high frequency transducer) within a three-year period was conducted. Differential diagnosis of fibroadenoma, lactating adenoma, mastitis, galactocele, breast cancer, abscess and “general” masses greater than 16 mm in diameter was stratified. Based on the breast imaging reporting in data system (BIRADS), lesions were classified as benign or malignant and recommendations of cytology made in cases of observed overlap findings. Image sonomorphologic information on mass-echogenic halo and non-uniform orientation were documented; while malignant factors like scar tissue, focal fibrosis and papillomas may be associated with a false positive (conclusion) result. Doppler studies on further mass evaluation is encouraged.

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The Value of Ultrasonography Combined with Compression Technique in Differentiation between Benign and Malignant Breast Masses

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2001.44.4.539 ◽

2001 ◽

Vol 44 (4) ◽

pp. 539

Author(s):

Seong Kuk Yoon ◽

Ki Nam Lee ◽

Won Jung Jung ◽

Kyung Jin Nam

Keyword(s):

Compression Technique ◽

Breast Masses ◽

Malignant Breast

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Axial-Shear Strain Imaging for Differentiating Benign and Malignant Breast Masses

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2010.07.008 ◽

2010 ◽

Vol 36 (11) ◽

pp. 1813-1824 ◽

Cited By ~ 30

Author(s):

Haiyan Xu ◽

Min Rao ◽

Tomy Varghese ◽

Amy Sommer ◽

Sara Baker ◽

...

Keyword(s):

Shear Strain ◽

Strain Imaging ◽

Breast Masses ◽

Axial Shear ◽

Malignant Breast

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Qualitative Diagnosis of Solid Breast Mass by Blood Flow in Solid Breast Mass Based on Color Doppler Ultrasound

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2021.3682 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1608-1615

Author(s):

Ding Zuopeng ◽

Liu Weiyong ◽

Hu Chunmei ◽

Wang Tao ◽

Wang Mingming

Keyword(s):

Breast Cancer ◽

Blood Flow ◽

Differential Diagnosis ◽

Color Doppler ◽

Flow Characteristics ◽

Flow Distribution ◽

Color Doppler Ultrasound ◽

Blood Flow Distribution ◽

Breast Masses ◽

Malignant Breast

The incidence of breast cancer ranks first among female malignant tumor. With the increase of the sensitivity of color Doppler ultrasound blood flow, the blood flow distribution in and around the tumor can be clearly displayed, and the analysis of hemodynamic parameters is provided, which provides convenience for the study of tumor blood flow characteristics. Studies have shown that tumor cells can secrete a substance called angiogenesis factor, which makes the tumor site form a rich vascular network to promote tumor growth and metastasis. The tumor has many new blood vessels, abnormal structure, thin wall, lack of muscle layer, and is prone to form arteriovenous rash. These characteristics provide a pathological basis for color Doppler flow imaging (CDFI) for the diagnosis of breast cancer. This article discusses the role of two-dimensional sonographic features in the differential diagnosis of benign and malignant breast masses, CDFI was used to study the blood flow distribution and hemodynamic characteristics in benign and malignant breast masses; explore the value of blood flow characteristics and blood flow parameters in the differential diagnosis of breast masses. The experimental results show that the detection rate of blood flow signals and the classification of blood flow signals in the malignant group are higher than those in the benign group, mainly level II and III blood flow, and the irregular branched blood flow is more common, especially when the tumor appears penetrating blood flow supports the diagnosis of malignancy. PSV, RI and PI have a certain differential meaning in the diagnosis of benign and malignant breast masses. PSV, RI and PI of malignant masses are higher than benign masses. For tumors without obvious necrosis, the larger the tumor diameter, the richer the blood flow and the higher the blood flow grade is. The malignant tumors have more blood flow than the benign ones.

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