Low-Dose High-Resolution CT of the Chest in Children and Young Adults

Background: The purpose of this study was to evaluate High-Resolution CT (HRCT) findings in SARS-CoV-2-related ARDS survivors treated with prolonged low-dose methylprednisolone after hospital discharge. Methods: A total of 44 consecutive patients (M: 32, F: 12, average age: 64), hospitalised in our department from April to September 2020 for SARS-CoV-2-related ARDS, who had a postdischarge CT scan, were enrolled into this retrospective study. We reviewed the electronic medical charts to collect laboratory, clinical, and demographic data. The CT findings were evaluated and classified according to lung segmental distribution. The imaging findings were correlated with spirometry results and included ground glass opacities (GGOs), consolidations, reticulations, bronchiectasis/bronchiolectasis, linear bands, and loss of pulmonary volume. Results: Alterations in the pulmonary parenchyma were observed in 97.7% of patients at HRCT (median time lapse between ARDS diagnosis and HRCT: 2.8 months, range 0.9 to 6.7). The most common findings were linear bands (84%), followed by GGOs (75%), reticulations (34%), bronchiolectasis (32%), consolidations (30%), bronchiectasis (30%) and volume loss (25%). They had a symmetric distribution, and both lower lobes were the most affected areas. Conclusions: A reticular pattern with a posterior distribution was observed 3 months after discharge from severe COVID-19 pneumonia, and this differs from previously described postCOVID-19 fibrotic-like changes. We hypothesized that the systematic use of prolonged low-dose of corticosteroid could be the main reason of this different CT scan appearance.

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P06.02 Efficacy of Arc based Radiation in children & young adults with Medulloblastoma

Neuro-Oncology ◽

10.1093/neuonc/noab180.080 ◽

2021 ◽

Vol 23 (Supplement_2) ◽

pp. ii24-ii24

Author(s):

S M Mathew ◽

A S U ◽

C V V ◽

V Lokesh

Keyword(s):

Young Adults ◽

Vertebral Body ◽

Low Dose ◽

Age Groups ◽

Normal Brain ◽

Low Dose Radiation ◽

Arc Therapy ◽

Children And Young Adults ◽

Ct Density ◽

Dose Radiation

Abstract BACKGROUND To compare doses to Organs At Risk and assess low dose radiation bath by Cranio Spinal Irradiation in children and young adults with Medulloblastoma between different Techniques. MATERIAL AND METHODS 30 Patients [Median Age: 8(5–23), M: F= 2:1] with Medulloblastoma, planned for Craniospinal Irradiation by Arc based Radiotherapy (VMAT- Elekta) also had an alternative Radiotherapy Plan (IMRT/ 3DCRT) to compare radiation doses to critical OARs (Cochlea, Thyroid, Heart) and low dose radiation bath to Vertebral Body and Supratentorial normal brain). Mean doses of Organs in parallel, Maximum doses of organs in series and Integral Dose was compared. Pre radiation Vertebral Body CT Density (HU) and the absorbed dose to it at various levels was estimated for each patient on the TPS. With the PTV coverage being 95% to the volume, dosimetrically superior plan was chosen for therapy. RESULTS The cohort had a risk stratum in the ratio 4:1 (Standard: High). IHC based molecular subtyping showed WNT, SHH and Non WNT/ Non SHH sub type (3:1:2). For ease of Analysis, the sample was divided among age groups into <8 years, 8–12 years and >12 years. Among the various Age groups, children < 8 years received the lowest dose of 21 Gy to Thyroid via Arc Therapy [(27Gy±4Gy) vs (31Gy± 3Gy)]. Children at 8–12 years received the lowest mean dose of 35 Gy with Arc plan to B/L Cochlea. [(36Gy± 4Gy) vs 41Gy± 4 Gy)]. Significant reduction of Mean dose to the heart was noted in >12 years with Arc [(8 Gy± 1Gy) vs(10 Gy± 2 Gy)]. The Mean CT density by HU of Vertebral Body (Thoraco-Lumbar) estimated were 145 HU, 195 HU and 315 HU in three age groups. Mean Doses to the Vertebrae was significantly lower with VMAT in kids < 8 years. ([3211 cGy ± 80 cGy] vs [3397 cGy ± 70cGy]). Supratentorial brain (basi frontal) received an additional [373.9 cGy ± 0.2Gy] vs[425 cGy ±0.3 Gy]) during PF Boost. CONCLUSION Arc Therapy in Medulloblastoma reduces in field normal tissue radiation dose (Thyroid, Cochlea and heart) at respective ages of <8 years, 8–12 years and > 12 years as well as the low dose radiation bath to structures (Vertebral body and Supratentorial brain) beyond the target volume which may reduce long term complications in children and young adults.

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Cortisol response to low dose versus standard dose (back-to-back) adrenocorticotrophic stimulation tests in children and young adults with thalassemia major

Indian Journal of Endocrinology and Metabolism ◽

10.4103/2230-8210.122620 ◽

2013 ◽

Vol 17 (6) ◽

pp. 1046 ◽

Cited By ~ 4

Author(s):

AshrafT Soliman ◽

Mohamed Yassin ◽

Nadra M. S.Abdel Majuid ◽

Aml Sabt ◽

MohamedO Abdulrahman ◽

...

Keyword(s):

Young Adults ◽

Low Dose ◽

Standard Dose ◽

Thalassemia Major ◽

Cortisol Response ◽

Stimulation Tests ◽

Children And Young Adults

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Aneurysmal Bone Cyst of the Skull

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100046023 ◽

1984 ◽

Vol 11 (4) ◽

pp. 466-471 ◽

Cited By ~ 29

Author(s):

N.O. Ameli ◽

K. Abbassioun ◽

A. Azod ◽

H. Saleh

Keyword(s):

Young Adults ◽

Aneurysmal Bone Cyst ◽

Low Dose ◽

Bone Cyst ◽

Bone Cysts ◽

Complete Excision ◽

Low Dose Radiotherapy ◽

Aneurysmal Bone Cysts ◽

Children And Young Adults ◽

Prompt Diagnosis

ABSTRACTAneurysmal bone cysts rarely affect the skull. Thirty-six cases including four reported in this paper are reviewed. The condition usually affects children and young adults and progresses rapidly. It may result in raised intracranial or intraorbital pressure. Complete excision of the mass is the treatment of choice, but if not feasible curettage followed by low dose radiotherapy is effective. As the prognosis in this condition is good, prompt diagnosis and early treatment are of utmost importance.

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