Quantitative measures of background parenchymal enhancement predict breast cancer risk

2020 ◽  
Author(s):  
Bethany L. Niell ◽  
Mahmoud Abdalah ◽  
Olya Stringfield ◽  
Natarajan Raghunand ◽  
Dana Ataya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Background Parenchymal Enhancement ◽  
Parenchymal Enhancement

scholarly journals Population-Based Assessment of the Association Between Magnetic Resonance Imaging Background Parenchymal Enhancement and Future Primary Breast Cancer Risk

2019 ◽  
Vol 37 (12) ◽  
pp. 954-963 ◽  
Author(s):  
Vignesh A. Arasu ◽  
Diana L. Miglioretti ◽  
Brian L. Sprague ◽  
Nila H. Alsheik ◽  
Diana S.M. Buist ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Density ◽  
Ductal Carcinoma ◽  
Breast Mri ◽  
Resonance Imaging ◽  
Background Parenchymal Enhancement ◽  
Parenchymal Enhancement

PURPOSE To evaluate comparative associations of breast magnetic resonance imaging (MRI) background parenchymal enhancement (BPE) and mammographic breast density with subsequent breast cancer risk. PATIENTS AND METHODS We examined women undergoing breast MRI in the Breast Cancer Surveillance Consortium from 2005 to 2015 (with one exam in 2000) using qualitative BPE assessments of minimal, mild, moderate, or marked. Breast density was assessed on mammography performed within 5 years of MRI. Among women diagnosed with breast cancer, the first BPE assessment was included if it was more than 3 months before their first diagnosis. Breast cancer risk associated with BPE was estimated using Cox proportional hazards regression. RESULTS Among 4,247 women, 176 developed breast cancer (invasive, n = 129; ductal carcinoma in situ,n = 47) over a median follow-up time of 2.8 years. More women with cancer had mild, moderate, or marked BPE than women without cancer (80% v 66%, respectively). Compared with minimal BPE, increasing BPE levels were associated with significantly increased cancer risk (mild: hazard ratio [HR], 1.80; 95% CI, 1.12 to 2.87; moderate: HR, 2.42; 95% CI, 1.51 to 3.86; and marked: HR, 3.41; 95% CI, 2.05 to 5.66). Compared with women with minimal BPE and almost entirely fatty or scattered fibroglandular breast density, women with mild, moderate, or marked BPE demonstrated elevated cancer risk if they had almost entirely fatty or scattered fibroglandular breast density (HR, 2.30; 95% CI, 1.19 to 4.46) or heterogeneous or extremely dense breasts (HR, 2.61; 95% CI, 1.44 to 4.72), with no significant interaction ( P = .82). Combined mild, moderate, and marked BPE demonstrated significantly increased risk of invasive cancer (HR, 2.73; 95% CI, 1.66 to 4.49) but not ductal carcinoma in situ (HR, 1.48; 95% CI, 0.72 to 3.05). CONCLUSION BPE is associated with future invasive breast cancer risk independent of breast density. BPE should be considered for risk prediction models for women undergoing breast MRI.

Background Parenchymal Enhancement at Contrast-Enhanced Spectral Mammography (CESM) as a Breast Cancer Risk Factor

2020 ◽  
Vol 27 (9) ◽  
pp. 1234-1240 ◽  
Author(s):  
Vera Sorin ◽  
Yael Yagil ◽  
Anat Shalmon ◽  
Michael Gotlieb ◽  
Renata Faermann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Cancer Risk Factor ◽  
Cancer Risk Factor ◽  
Background Parenchymal Enhancement ◽  
Contrast Enhanced ◽  
Parenchymal Enhancement

Relationship between Background Parenchymal Enhancement on High-risk Screening MRI and Future Breast Cancer Risk

2019 ◽  
Vol 26 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Lars J. Grimm ◽  
Ashirbani Saha ◽  
Sujata V. Ghate ◽  
Connie Kim ◽  
Mary Scott Soo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Risk Screening ◽  
Background Parenchymal Enhancement ◽  
Parenchymal Enhancement ◽  
High Risk Screening
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