scholarly journals Physico–Chemical and Bio-Chemical Studies on Some Mn (II) ion chelates with Physiological active Mixed Ligands

2020 ◽  
Vol 16 (6) ◽  
pp. 78-82
Author(s):  
R.N. Sharma ◽  
◽  
Ashok Kumar Mishra ◽  
B. Laxmi Kanth ◽  
Soni Kumari ◽  
...  
Keyword(s):  
Isonicotinic Acid ◽  
Magnetic Measurement ◽  
Acid Hydrazide ◽  
Conductivity Measurement ◽  
Far Infrared ◽  
Mixed Ligands ◽  
Spectral Bands ◽  
Physico Chemical ◽  
Donor Element ◽  
Chemical Studies

Some air stable electrolytic and non-electrolytic mixed ligand complexes of Mn(ll) ion with isonicotinic acid hydrazide have been synthesized and characterized by various physico chemical data based on micro analytical analysis, magnetic measurement, conductivity measurement, near and far infrared and electronic spectrophotometric studies. Various vibrational and spectral bands of ligand and complexes were studied and compared. The mode of shifting were used to diagnose the coordinating behaviour of donor element of ligand with Mn (ll) ions. All complexes were screened against Aspergillus flavus and classified as a mixed fungicide. Tentative octahedral geometry has been assigned for all Mn (ll)complexes

scholarly journals Physico-chemical studies of some aminobenzoic acid hydrazide complexes

2004 ◽  
Vol 69 (4) ◽  
pp. 255-264 ◽  
Author(s):  
Abd El ◽  
Abd El ◽  
Gamel El ◽  
Abd El
Keyword(s):  
Acid Hydrazide ◽  
Conductometric Titration ◽  
Aminobenzoic Acid ◽  
X Ray ◽  
Physico Chemical ◽  
Coordination Process ◽  
Different Temperatures ◽  
Chemical Studies ◽  
The Stability ◽  
Thermal Stability Of

The stability constants and related thermodynamic functions characterizing the formation of divalent Ni, Cu, Zn, Cd and Hg complexes with o- and p-aminobenzoic acid hydrazide were determined potentiometrically at different temperatures. The formations of the complexes are endothermic processes. The formed bonds are mainly electrostatic. Conductometric titration was carried out to determine the stoichiometry and stability of the formed complexes. The structures of complexes were characterized by their IR, 1H-NMR and 13C-NMR spectra, as well as X-ray diffractograms. The coordination process takes place through the carbonyl group and the terminal hydrazinic amino group. The thermal stability of the complexes was followed in the temperature range 20?600 ?C.

Hybrid Design of Isonicotinic Acid Hydrazide Derivatives: Machine Learning Studies, Synthesis and Biological Evaluation of their Antituberculosis Activity

2020 ◽  
Vol 17 (3) ◽  
pp. 365-375
Author(s):  
Vasyl Kovalishyn ◽  
Diana Hodyna ◽  
Vitaliy O. Sinenko ◽  
Volodymyr Blagodatny ◽  
Ivan Semenyuta ◽  
...  
Keyword(s):  
Machine Learning ◽  
Isonicotinic Acid ◽  
Acid Hydrazide ◽  
Predictive Ability ◽  
Antitubercular Activity ◽  
Biological Evaluation ◽  
Starting Point ◽  
Binary Classifiers ◽  
Synthesis And Biological Evaluation

Background: Tuberculosis (TB) is an infection disease caused by Mycobacterium tuberculosis (Mtb) bacteria. One of the main causes of mortality from TB is the problem of Mtb resistance to known drugs. Objective: The goal of this work is to identify potent small molecule anti-TB agents by machine learning, synthesis and biological evaluation. Methods: The On-line Chemical Database and Modeling Environment (OCHEM) was used to build predictive machine learning models. Seven compounds were synthesized and tested in vitro for their antitubercular activity against H37Rv and resistant Mtb strains. Results: A set of predictive models was built with OCHEM based on a set of previously synthesized isoniazid (INH) derivatives containing a thiazole core and tested against Mtb. The predictive ability of the models was tested by a 5-fold cross-validation, and resulted in balanced accuracies (BA) of 61–78% for the binary classifiers. Test set validation showed that the models could be instrumental in predicting anti- TB activity with a reasonable accuracy (with BA = 67–79 %) within the applicability domain. Seven designed compounds were synthesized and demonstrated activity against both the H37Rv and multidrugresistant (MDR) Mtb strains resistant to rifampicin and isoniazid. According to the acute toxicity evaluation in Daphnia magna neonates, six compounds were classified as moderately toxic (LD50 in the range of 10−100 mg/L) and one as practically harmless (LD50 in the range of 100−1000 mg/L). Conclusion: The newly identified compounds may represent a starting point for further development of therapies against Mtb. The developed models are available online at OCHEM http://ochem.eu/article/11 1066 and can be used to virtually screen for potential compounds with anti-TB activity.

Design, synthesis and physico-chemical studies of a Co(II)/Co(III) mixed-valence complex: An experimental and DFT approach.

2021 ◽  
pp. 130384
Author(s):  
Intissar Hamdi ◽  
Noureddine Mhadhbi ◽  
Noureddine Issaoui ◽  
Andreas Roodt ◽  
Mark M. Turnbull ◽  
...  
Keyword(s):  
Mixed Valence ◽  
Design Synthesis ◽  
Physico Chemical ◽  
Chemical Studies ◽  
Mixed Valence Complex

scholarly journals THE ISOLATION AND PROPERTIES OF THE ISONICOTINIC ACID HYDRAZIDE ANALOGUE OF DIPHOSPHOPYRIDINE NUCLEOTIDE

1954 ◽  
Vol 209 (2) ◽  
pp. 467-484 ◽  
Author(s):  
Leonard J. Zatman ◽  
Nathan O. Kaplan ◽  
Sidney P. Colowick ◽  
Margaret M. Ciotti
Keyword(s):  
Isonicotinic Acid ◽  
Acid Hydrazide ◽  
Isonicotinic Acid Hydrazide

scholarly journals Lysyl oxidase activity and elastin/glycosaminoglycan interactions in growing chick and rat aortas.

1987 ◽  
Vol 105 (3) ◽  
pp. 1463-1469 ◽  
Author(s):  
C Fornieri ◽  
M Baccarani-Contri ◽  
D Quaglino ◽  
I Pasquali-Ronchetti
Keyword(s):  
Hydrophobic Interactions ◽  
Isonicotinic Acid ◽  
Lysyl Oxidase ◽  
Acid Hydrazide ◽  
Elastic Fibers ◽  
Amino Groups ◽  
Lysine Residues ◽  
Oxidase Inhibition

Hydrophobic tropoelastin molecules aggregate in vitro in physiological conditions and form fibers very similar to natural ones (Bressan, G. M., I. Pasquali Ronchetti, C. Fornieri, F. Mattioli, I. Castellani, and D. Volpin, 1986, J. Ultrastruct. Molec. Struct. Res., 94:209-216). Similar hydrophobic interactions might be operative in in vivo fibrogenesis. Data are presented suggesting that matrix glycosaminoglycans (GAGs) prevent spontaneous tropoelastin aggregation in vivo, at least up to the deamination of lysine residues on tropoelastin by matrix lysyl oxidase. Lysyl oxidase inhibitors beta-aminopropionitrile, aminoacetonitrile, semicarbazide, and isonicotinic acid hydrazide were given to newborn chicks, to chick embryos, and to newborn rats, and the ultrastructural alterations of the aortic elastic fibers were analyzed and compared with the extent of the enzyme inhibition. When inhibition was greater than 65% all chemicals induced alterations of elastic fibers in the form of lateral aggregates of elastin, which were always permeated by cytochemically and immunologically recognizable GAGs. The number and size of the abnormal elastin/GAGs aggregates were proportional to the extent of lysyl oxidase inhibition. The phenomenon was independent of the animal species. All data suggest that, upon inhibition of lysyl oxidase, matrix GAGs remain among elastin molecules during fibrogenesis by binding to positively charged amino groups on elastin. Newly synthesized and secreted tropoelastin has the highest number of free epsilon amino groups, and, therefore, the highest capability of binding to GAGs. These polyanions, by virtue of their great hydration and dispersing power, could prevent random spontaneous aggregation of hydrophobic tropoelastin in the extracellular space.

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