Synthesis of Fluorinated Heterocyclic Compounds for Pharmacological Screening

A series of derivatives of (E)-6-chloro-5-fluoro-2-styryl-1H-benzo[d]imidazole, and 5-fluoro-2-methylN-phenyl-1H-benzo[d]imidazol-6-amine was synthesized. Compounds confirmed by melting point, FT-IR, 1HNMR, Mass spectral analytical techniques and predicted for their ADME, Pharmacokinetic properties.Synthesized compounds screened for better antibacterial and antiinflammatory activity. To synthesize a series of novel trisubstituted fluorinated benzimidazole derivatives and evaluate the physicochemical, ADME and pharmacokinetic properties and biological activity. The starting material Flouro-chloro-aniline ona series of reaction such as acetylation, nitration, deacetylation followed by reductionto get 4-fluoro-5-chloroorthophenylene diamine. The di-amino compound cyclized with acetyl chloride to obtain 6-chloro-5-fluoro-2- methyl-1H-benzimidazole which on reaction with various aromatic aldehyde forms series of compounds 31(a-h), and with various anilines forms compounds 32(a-j). Physicochemical, ADME and pharmacokinetic properties predicted Insilco. Antimicrobial activity screened by Agar diffusion method. In vitro antiinflammatory activity screened by protein denaturation assay.The compounds synthesized confirmed by melting Point, FT-IR, 1HNMR, Mass spectral analytical techniques and predicted for their ADME, Pharmacokinetic properties in silico. The compounds screened and confirmed with moderate antimicrobial, and in vitro antiinflammatory activity.

Study of Acoustical and Physico-chemical Properties for the Ternary Mixture of (Toluene+ Chlorobenzene + Cyclohexane) at 298.15 K Temperature

Ultrasonic velocity (U), density (ρ) for the ternary mixture of (Toluene + Chlorobenzene + Cyclohexane) in the various range of composition has been carried out at 298.15K. The observed data have been utilized to calculate various acoustical parameters like Isentropic compressibility (KS), Intermolecular free length (Lf) and acoustic impedance (Z). The various excess properties like excess ultrasonic velocity(UE ), excess acoustic impedance (ZE ), excess Isentropic compressibility (KS E ) and excess Inter molecular free length (Lf E ) have been calculated and using standard relations to the Redlich-Kister equation. The trend of acoustical and physicochemical parameters confirm the dynamics of molecules at temperature and the magnitude of intermolecular interactions among the constituents of the mixture always reflects the nature of substance. The variations in sign and values of these parameters are help us to know the interaction between component molecules and structural arrangement of the liquid mixture.

Study of Molecular interaction in Binary Mixtures containing N, N-Dimethylformamide and n-Butanol

The acoustic studies of the interactions between alcohol molecules and water soluble polar solvent DMF are significant for understanding the relationships between structure and function of polar molecule like DMF, and for explaining the mechanisms of interaction of alcoholic OH group with an electronegative moiety. In this piece of work Ultrasonic velocity, density and viscosity have been measured at 298 K, 308 K, 318 K and 328 K for mixture of N,N-dimethylformamide (DMF) and n-butanol, the frequency being maintained at a constant value. The experimental data have been used to calculate the acoustical and thermodynamical parameters like adiabatic compressibility, free length, free volume, internal pressure, acoustic impedance, Gibbs free energy

Characteristic evaluation of adsorption efficiency of activated wood charcoals in adsorbing acetic acid

Activated wood charcoal (Carbonized) acts as an excellent adsorbent and it finds wide applications. The present study was carried on four different activated wood charcoals Salix (Sac), Pinus (Pac), Anacardium occidentale (AOac) and Calophyllum inophyllum (CIac) found in Karwar district, Karnataka, India. The activated charcoal was prepared by carbonizing in a muffle-furnace at 800 0 C and the yield of carbonized carbon was about 50%. SEM morphology and EDX spectrum indicates the homogeneity and purity of the activated wood charcoals containing 65-86% carbon to that of commercial charcoal (89% C) and hydrogen is absent. Langmuir and Freundlich adsorption isotherms are well-correlated and verified. The regressive coefficient (R2 ) of isotherms recorded a higher value above 0.92 which proves the homogeneous and even adsorption phenomenon by the activated wood charcoals. Sac and AOac recorded highest percentage of removal of acetic acid of about 40-60% and 20-26% with Cac (20-25%) where Pac and CIac recorded 17-23% which is relatively near to the commercially activated charcoal(Cac). On comparison of relative percentage of removal of acetic by activated wood charcoals with commercial charcoal, the activated wood charcoals serve as an efficient adsorbent for acetic acid. The cost and availability of the wood is cheaper.

Physico–Chemical and Bio-Chemical Studies on Some Mn (II) ion chelates with Physiological active Mixed Ligands

Some air stable electrolytic and non-electrolytic mixed ligand complexes of Mn(ll) ion with isonicotinic acid hydrazide have been synthesized and characterized by various physico chemical data based on micro analytical analysis, magnetic measurement, conductivity measurement, near and far infrared and electronic spectrophotometric studies. Various vibrational and spectral bands of ligand and complexes were studied and compared. The mode of shifting were used to diagnose the coordinating behaviour of donor element of ligand with Mn (ll) ions. All complexes were screened against Aspergillus flavus and classified as a mixed fungicide. Tentative octahedral geometry has been assigned for all Mn (ll)complexes

Studies on the effect of Dielectric constants of Aquo-DMF Solvent- System of the Solvolysis Products of Nicotinates

From the eenhancement observed in G* values with simultaneous decrease in the values of H and S* of the reaction, it is concluded that the organic co-solvent dimethyl formamide (DMF) acts as entropy controller and enthalpy stimulator solvent for alkali catalysed solvolysis of Methyl nicotinate. Form the evaluated values of water molecules associated with the activated complex of the reaction which are found to increase with increase in the temperature of the reaction, it is inferred that the bimolecular mechanistic path is changed to unimolecular in presence of the organic component (DMF) of the reaction media. The numerical value of Iso-Kinetic temperature of the reaction which comes to be nearly 287.5 (below 300) indicates that there is weak but considerable solvent-solute interaction in the aquo-DMF solvent system.

Studies on the effect of Aquo-Dioxan Solvent System on the biochemical behaviour of the Substituted Valerates

Valerates and Substituted Valerates have been found to be useful for humanbeings as its hydrolysis product i.e. valence acid is used in the society in the form of perfumes flavours platister, vinyl stabilizer and pharmaceuyicals. With a views to study the solvent effect of 1:4 dioxan on the biochemical behivour of the hydrolysis product of a substituted valerate, the kinetic of Alkali catalysed of mothyl iso-valerate was studies in aquodioxan media. Increase observed in free energy activation with simultaneous increase in the value of both the activation H* and S*, it is concluded that in the presence of dioxan with reaction media, the reaction becomes enthaipy dominating and entropy controlled. From the evaluated values of the reaction which comes to be 329.0, it is inferred that Barclay-Butler rule is obeyed by the reaction and there is strong solvent- solute interaction in presence of dioxan the reaction media.

Synthesis, structural characterization and antibacterial studies of Fluoroquinolone Drug-Ciprofloxacin

he vibrational spectroscopy, such as FTIR has been used to measure the vibrational modes of fluoroquinolones, provides information about structural differences of its individual members. Form the interpreted spectral data Ciprofloxacin has been distinguished by the presence of different substituents in their parent nucleus. FTIR study provides the most direct and definitive identification of fluoroquinolone and offer a means for qualitative analysis of newly synthesized fluroquinolone drug-Ciprofloxacin. Ciprofloxacin is an antibiotic used to treat a number of bacterial infections. This includes bone and joints infection intra abdominal infection certain types of infectious diarrhea, respiratory tract infection skin infections, typhoid fever and urinary tract infections.

Kinetics and mechanism of oxidation of mandelic acid with Bi(V) in phosphoric acid medium

The kinetics and mechanism of oxidation of Mandelic acid with Bi(V) has been investigated in phosphoric acid medium. The order with respect to substrate and oxidant each is one. The reaction rate is independent of [H+] ion as well as [Bi(III)]. The reaction rate decreases with increasing ionic strength indicating reactive species of opposite charge. The simple rate law explained all the experimental observations. The mode of electron transfer from the substrate to Bi(V) has been indicated is a bridged outer sphere mechanism.