scholarly journals Post-Transplant Cardiovascular Disease

2021 ◽  
pp. CJN.00520121
Author(s):  
Kelly A. Birdwell ◽  
Meyeon Park
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Kidney Transplant ◽  
Optimal Strategies ◽  
Future Research ◽  
Kidney Transplant Recipients ◽  
Post Transplant ◽  
Treatment And Prevention ◽  
Artery Disease

Cardiovascular disease remains a leading cause of death and morbidity in kidney transplant recipients and a common reason for post-transplant hospitalization. Several traditional and nontraditional cardiovascular risk factors exist, and many of them present pretransplant and worsened, in part, due to the addition of immunosuppression post-transplant. We discuss optimal strategies for identification and treatment of these risk factors, including the emerging role of sodium-glucose cotransporter 2 inhibitors in post-transplant diabetes and cardiovascular disease. We present common types of cardiovascular disease observed after kidney transplant, including coronary artery disease, heart failure, pulmonary hypertension, arrhythmia, and valvular disease. We also discuss screening, treatment, and prevention of post-transplant cardiac disease. We highlight areas of future research, including the need for goals and best medications for risk factors, the role of biomarkers, and the role of screening and intervention.

Risk Factors and Outcomes of Post‐Transplant Erythrocytosis among Adult Kidney Transplant Recipients: A Systematic Review and Meta‐Analysis

2021 ◽  
Author(s):  
Poemlarp Mekraksakit ◽  
Boonphiphop Boonpheng ◽  
Natnicha Leelaviwat ◽  
Samapon Duangkham ◽  
Anasua Deb ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Kidney Transplant ◽  
Meta Analysis ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Post Transplant ◽  
Adult Kidney

scholarly journals Risk Factors for the Development of BK Virus Infection in Kidney Transplant Recipients in Guilan Province during 2007-2015

2020 ◽  
Author(s):  
Masoud Khosravi ◽  
Mahlagha Dadras ◽  
Ali Monfared ◽  
Siamak Granmaieh ◽  
Mohammad Shenagari Rashti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Virus Infection ◽  
Kidney Transplant ◽  
Viral Genome ◽  
Kidney Biopsy ◽  
Significant Risk ◽  
Bk Virus ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Post Transplant

Abstract Purpose: Polyomavirus nephropathy has been recognized as an important cause of silent loss of kidney transplant function in 3-5% of kidney transplant recipients. We evaluate the risk factors associated with BK virus infection in our kidney transplant recipients.Materials and Methods: We collected clinical information, urinary Decoy cell, and blood PCR tests for polyomavirus infection in our 223 kidney transplant recipients undergoing surgery at Razi hospital at Guilan University of Medical Sciences between 2007 and 2015. In case of high virus count or if plasma creatinine was elevated, a kidney biopsy would be performed. SPSS version 18 were used for analysis of data.Results: Among 223 patients, 116 (52%) were male, 107 females (48%). Mean age of participants were 49.6 years. Of 223 kidney transplant patients enrolled in this study, 41 (18.3%) had viral genome in their urine, and of these 41 patients, 15 persons (6.7%) had viral genome in their blood. Only 3 patients out of 10, have had BK Virus nephropathy in their kidney biopsy. Among risk factors, we found that post-transplant duration, and use of anti-thymocyte globulin, were most significant risk factors for finding Decoy cells in urine of patients (p<0.01).Conclusions: Post-transplant time, specially the first 6 months because of strong immunosuppression, and thereafter, use of anti-thymocyte globulin (for prophylaxis or treatment of rejection) were recognized as most important risk factors for reactivation of polyomavirus infection in our patients. We concluded that kidney transplant recipients should be monitored in episodically after transplant.

Role of Chlamydia pneumoniae in atherosclerosis

2008 ◽  
Vol 114 (8) ◽  
pp. 509-531 ◽  
Author(s):  
Caroline Watson ◽  
Nicholas J. Alp
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Events ◽  
Chlamydia Pneumoniae ◽  
Attributable Risk ◽  
Future Research ◽  
Infectious Agents ◽  
Contributory Factors ◽  
Progression Of Atherosclerosis

Cardiovascular disease, resulting from atherosclerosis, is a leading cause of global morbidity and mortality. Genetic predisposition and classical environmental risk factors explain much of the attributable risk for cardiovascular events in populations, but other risk factors for the development and progression of atherosclerosis, which can be identified and modified, may be important therapeutic targets. Infectious agents, such as Chlamydia pneumoniae, have been proposed as contributory factors in the pathogenesis of atherosclerosis. In the present review, we consider the experimental evidence that has accumulated over the last 20 years evaluating the role of C. pneumoniae in atherosclerosis and suggest areas for future research in this field.

scholarly journals Metabolic risk factors for cardiovascular disease in pancreas and kidney transplant recipients

Diabetologia ◽  
1991 ◽  
Vol 34 (S1) ◽  
pp. S44-S46 ◽  
Author(s):  
G. Nyberg ◽  
G. Fager ◽  
L. Mj�rnstedt ◽  
M. Olausson
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Kidney Transplant ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Post-Transplant Diabetes Mellitus in Kidney Transplant Recipients: A Multi-Center Study

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0000862021
Author(s):  
Rubab F. Malik ◽  
Yaqi Jia ◽  
Sherry G. Mansour ◽  
Peter P. Reese ◽  
Isaac E. Hall ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Kidney Transplant ◽  
Graft Failure ◽  
De Novo ◽  
Kidney Transplant Recipients ◽  
Post Transplant ◽  
Kidney Recipients ◽  
Recipient Age

Background: De novo post-transplant diabetes mellitus (PTDM) is a common complication after kidney transplant (KT). Most recent studies are single-center with various approaches to outcome ascertainment. Methods: In a multi-center longitudinal cohort of 632 non-diabetic adult kidney recipients transplanted in 2010-2013, we ascertained outcomes through detailed chart review at 13 centers. We hypothesized that donor characteristics such as sex, HCV infection, and kidney donor profile index (KDPI) and recipient characteristics such as age, race, BMI, and increased HLA mismatches would affect the development of PTDM among KT recipients. We defined PTDM as hemoglobin A1c ≥6.5%, pharmacological treatment for diabetes, or documentation of diabetes in electronic medical records. We assessed PTDM risk factors and evaluated for an independent time-updated association between PTDM and graft failure using regression. Results: Mean recipient age was 52±14 years, 59% were male, 49% were Black. Cumulative PTDM incidence 5 years post-KT was 29% (186). Independent baseline PTDM risk factors included older recipient age (p<0.001) and higher BMI (p=0.006). PTDM was not associated with all-cause graft failure [adjusted Hazard Ratio (aHR) 1.10 (95% CI: 0.78-1.55)], death-censored graft failure [aHR 0.85 (0.53-1.37)], or death [aHR 1.31 (0.84-2.05)] at median follow-up of 6 (4.0,6.9) years post-KT. Induction and maintenance immunosuppression were not different between patients who did and did not develop PTDM. Conclusions: PTDM occurred commonly, and higher baseline BMI was associated with PTDM. PTDM was not associated with graft failure or mortality during the 6-year follow-up, perhaps due to short follow-up.

scholarly journals SP689THE ROLE OF TCF7L2 RS7903146 IN CORONARY ARTERY DISEASE IN NON-DIABETIC KIDNEY TRANSPLANT RECIPIENTS

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i324-i324
Author(s):  
Marco Quaglia ◽  
Claudio Musetti ◽  
Andrea Airoldi ◽  
Guido Merlotti ◽  
Salvatore Terrazzino ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Diabetic Kidney ◽  
Artery Disease ◽  
Tcf7l2 Rs7903146
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