ASSOCIATION OF SERUM SIALIC ACID AND SERUM URIC ACID LEVELS WITH FASTING BLOOD GLUCOSE LEVELS IN TYPE-2 DIABETES MELLITUS PATIENTS

Objectives: The objective of the study was to estimate the serum sialic acid and serum uric acid levels in patients with type-2 diabetes mellitus and non-diabetic individuals and determining the association of serum sialic acid and serum uric acid levels with fasting blood glucose levels in patients with type-2 diabetes mellitus and also in non-diabetic individuals. Methods: The study was a cross-sectional analysis where 70 individuals in the age group of 30–70 years participated during 6 months period. This included two groups, one for type-2 diabetes patients as cases and other non-diabetics as controls. In each group, 35 individuals participated. There were 15 males and 20 females in type-2 diabetic group and 16 males and 19 females in non-diabetic group. Fasting blood glucose, serum sialic acid, and serum uric acid were estimated in both the groups. Results: In this study, the serum sialic acid levels of type-2 diabetes mellitus were shown to be increased (76.60 ± 7.89) when compared to non-diabetics (39.66 ± 9.55) with a statistically significant, p < 0.001. The serum uric acid concentrations were also found to be slightly elevated in type-2 diabetes mellitus (4.48 ± 0.79) when compared to non-diabetics (4.28 ± 0.89) with a statistically non-significant, p = 0.323. Conclusion: Based on this study, it is concluded that serum sialic acid and serum uric acid levels have been found to be positively associated with type- 2 diabetes mellitus in both men and women, indicating the risk of developing microvascular complications in those patients. Therefore, estimating the sialic acid and uric acid levels can aid in the early diagnosis and prevention of microvascular complications caused by type-2 diabetes mellitus.

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ANGKA BANDING KADAR ASAM URAT AIR KEMIH TERHADAP SERUM DI DIABETES MELITUS TIPE 2 (Ratio of Urinary Uric Acid Levels and Serum Uric Acid in Type 2 Diabetes Mellitus)

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v21i1.1255 ◽

2018 ◽

Vol 21 (1) ◽

pp. 28

Author(s):

Amarensi Milka Betaubun ◽

Fitriani Mangarengi ◽

Ruland DN Pakasi

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Blood Glucose ◽

Serum Uric Acid ◽

Colorimetric Method ◽

Urinary Levels ◽

Urine Serum

Diabetes Mellitus (DM) belongs to the group of metabolic diseases. The long-term complications of diabetes such as: diabeticretinopathy, neuropathy, and nephropathy, can be prevented or reduced by controlling the blood glucose levels. Impaired glucose tolerance,hypertension and dyslipidemia can decrease the disappearance from proximal tubules resulting in an increase in serum uric acid. The aimof the study to know the ratio of uric acid urine/serum in DMT2 with controls. This research study used a cross sectional study was andconducted on 35 samples of type 2 diabetes mellitus and 35 control samples of In- and Out-patient Clinics at the Dr. Wahidin SudirohusodoHospital, Makassar. The blood glucose, uric acid levels and urine uric acid were examined by ABX Pentra 400 (colorimetric method). Thenumber of DMT2 male patients was higher than females. Most of their age were between 50−54 years. The ratio of the urinary levels ofurine/serum UA was positively correlated to: age, sex, urine UA in DMT2 and control. Their data were analyzed with unpaired t test (p =0.00). This research showed that the ratio of urine/serum UA in DMT2 was 1.5 times than the controls. The results of this study showedan increase in the ratio of urinary levels of serum uric acid as 1.5 times higher than the controls.

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A STUDY OF SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS CASES AND ITS COMPARISON WITH THE SERUM CREATININE LEVELS

10.36106/paripex/0302859 ◽

2021 ◽

pp. 20-22

Author(s):

Shajahan Shajahan ◽

Koneru Sri Lahari ◽

P. Kiranmai

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Serum Creatinine ◽

Serum Uric Acid ◽

Fasting Blood Glucose ◽

Control Group ◽

P Value

BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and is associated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemia and Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerular pressure leading to renal complications.High serum creatinine is an indicator of renal compromise. OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to find association between them. METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 Diabetes Mellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, Fasting Blood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulter AU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2 subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBS and creatinine was analysed statistically. RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value < 0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value <0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugar levels when compared to subgroup with serum uric acid <7 mg/dl. CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared to controls.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,it is important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.

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THE STUDY ON ASSOCIATION BETWEEN URIC ACID AND ALBUMINURIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

10.36106/ijsr/5304034 ◽

2021 ◽

pp. 1-3

Author(s):

Sk. Adnan Yusuf ◽

Debarshi Jana

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Serum Uric Acid ◽

Fasting Blood Glucose ◽

General Medicine ◽

Urinary Albumin ◽

Chronic Hyperglycemia

Introduction: Diabetes Mellitus (DM) is a metabolic disorder characterized by the presence of chronic hyperglycemia accompanied by greater or lesser impairment in the metabolism of carbohydrates, lipids and proteins resulting from defects in insulin secretion, action or both. Aims & objectives: The aim of this study is to evaluate the association between serum uric acid & urinary Albumin to Creatinine Ratio (ACR) among patients with type 2 diabetes mellitus. Material and Methods: 83 patients aged between 40 to 80 years was selected from Medicine OPD and indoor wards, Department of General Medicine, KPC Medical College & Hospital, West Bengal from 1august 2019 to 1august 2020. Type 2 Diabetics Melitus (T2DM) patients, Age: between 40 to 80 years. Age, Body weight, Height, BMI, serum uric acid, urinary albumin to creatine ratio (ACR), Fasting Blood Glucose (FBG), HbA1C, lipid profile, serum creatinine. Conclusion: Present study found that positive correlation between serum uric acid with DBP, FBS, HB1AC, Serum Createnine, TG and LDL. There was negative correlation between serum uric acid with GFR and HDL, which were statistically significant.

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CORRELATION OF SERUM URIC ACID LEVEL WITH GLYCAEMIC STATUS IN TYPE 2 DIABETES MELLITUS PATIENTS IN DARBHANGA

10.36106/ijsr/0636784 ◽

2021 ◽

pp. 68-70

Author(s):

Mritunjay Kumar ◽

Sheela Kumari ◽

Debarshi Jana

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Blood Glucose ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level

Objectives : Our study was to detect the correlation of serum uric acid level with glycaemic status and with lipid prole. And also evaluate the various biochemical parameters, anthropometric measurements, blood pressure, serum uric acid level and associated factors. Methods: A 100 subjects with type 2 diabetes mellitus as a case and 100 subjects with non diabetics as control with age group greater than 40 years were enrolled in this study. A detail history, dietary pattern, clinical examination and relevant investigation were performed. Anthropometric examination like as measurement of BMI, measurement of waist-hip ratio and biochemical investigations like as blood glucose, serum HbA1c estimation, serum uric acid and serum lipid prole were performed to all subjects. Results : Data was analyzed by using SPSS software. Mean±SD was observed. P value was taken ≤0.05 for signicant differences. Conclusion : Type 2 diabetes mellitus patients is a strong negative correlation between blood glucose level and serum uric acid level. So that serum uric acid can be used as an important parameter to assess future cardiovascular risk in a type 2 diabetes mellitus patient.

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Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

Journal of Current and Advance Medical Research ◽

10.3329/jcamr.v4i2.36358 ◽

2018 ◽

Vol 4 (2) ◽

pp. 58-62

Author(s):

Roksana Yeasmin ◽

MA Muttalib ◽

Kazi Nazneen Sultana ◽

Nizamul Hoque Bhuiyan ◽

Md Jamil Hasan Karami ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Rheumatoid Factor ◽

Serum Uric Acid ◽

Control Group ◽

Healthy Male ◽

Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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Epigenetic modulation of autophagy genes linked to diabetic nephropathy by administration of isorhamnetin in Type 2 diabetes mellitus rats

Epigenomics ◽

10.2217/epi-2020-0353 ◽

2021 ◽

Author(s):

Marwa Matboli ◽

Doaa Ibrahim ◽

Amany H Hasanin ◽

Mohamed Kamel Hassan ◽

Eman K Habib ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Light And Electron Microscopy ◽

Lipid Profiles ◽

Mirna Regulation ◽

Protein Levels

Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnetin (50 mg/kg/d) for 4 or 8 weeks. Fasting blood glucose, renal and lipid profiles were evaluated. Renal tissues were examined by light and electron microscopy. Autophagy genes ( FYCO1, ULK, TECPR1 and WIPI2) and miR-15b, miR-34a and miR-633 were assessed by qRT-PCR, and LC3A/B by immunoblotting. Results: Isorhamnetin improved fasting blood glucose, renal and lipid profiles with increased autophagosomes in renal tissues. It suppressed miRNA regulation of autophagy genes Conclusion: We propose a molecular mechanism for the isorhamnetin renoprotective effect by modulation of autophagy epigenetic regulators.

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