INHIBITION OF GASTRIC DEGRADATION OF OMEPRAZOLE USING A pH-SENSITIVE POLYMER AS A BINDER IN TABLET FORMULATION

Objective: This work was aimed at formulating omeprazole tablets using afzelia gum as a binder that is capable of inhibiting the gastric degradation of the drug. Methods: Afzelia gum at different concentrations of 0, 5, 10, 15, 20 and 30% was used as a binder to formulate omeprazole tablets. The tablets were formulated by direct compression and the batches labelled F1 to F6 respectively. A batch containing 15% hydroxypropyl methylcellulose (F7) was also formulated. The tablets were characterized; and dissolution in a pH 1.2 dissolution medium over 120 min period was studied. Aliquots taken every 20 min were analyzed by ultraviolet spectrophotometry to determine the amount of drug released and not degraded. Results: Amounts of drug released and not degraded at time 120 min were 53.1%, 57.3%, 57.8%, 58.8%, 62.1%, 83.4% and 90.0% for F1 to F7 respectively. Conclusion: Afzelia gum at a concentration of 30% is suitable for use as a binder in tablet formulation of omeprazole to ensure substantial inhibition of gastric degradation of the drug.

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Modulation of protein release from chitosan-alginate microcapsules using the pH-sensitive polymer hydroxypropyl methylcellulose acetate succinate

Journal of Microencapsulation ◽

10.3109/02652049609026035 ◽

1996 ◽

Vol 13 (5) ◽

pp. 497-508 ◽

Cited By ~ 37

Author(s):

A. O. Okhamafe ◽

B. Amsden ◽

W. Chu And ◽

M. F. A. Goosen

Keyword(s):

Hydroxypropyl Methylcellulose ◽

Ph Sensitive ◽

Protein Release ◽

Ph Sensitive Polymer

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IDENTIFICATION OF KEY VARIABLES AFFECTIN G DRUG RELEASE FROM LIPID MATRIX IN HYDROALCOHOLIC DISSOLUTION MEDIUM CONTAININ G HYDROXYPROPYL METHYLCELLULOSE

INDIAN DRUGS ◽

10.53879/id.53.11.10666 ◽

2016 ◽

Vol 53 (11) ◽

pp. 72-76

Author(s):

P. R Babariya ◽

◽

M. C Gohel ◽

V. T. Thakkar ◽

L. H. Baldaniya ◽

...

Keyword(s):

Drug Release ◽

Alcohol Intake ◽

Hydroxypropyl Methylcellulose ◽

Research Work ◽

Direct Compression ◽

Dissolution Medium ◽

Experimental Conditions ◽

Dissolution Study ◽

Key Variables ◽

Compritol 888 Ato

The present research work was undertaken to formulate modified release tablets of lornoxicam using Compritol 888 ATO as a lipid matrixing agent and to evaluate the tablets for dissolution in hydro-alcoholic dissolution media to meet the requirement of regulators. The dissolution study was also conducted in aqueous medium containing alcohol and hydroxylpropyl methylcellulose to mimic the viscosity and pH after food and alcohol intake. The tablets were prepared by direct compression by adopting the concept of design of experiments and evaluated mainly for dissolution studies in aqueous dissolution media containing 10, 25 and 40% ethyl alcohol. The formulated tablets satisfied the USP requirements of drug release at 2, 6 and 10 hr. The drug release was insignificantly altered when the dissolution study was conducted in media containing increasing amount of alcohol probably due to higher solubility of the drug in alcohol. The drug release was suppressed when HPMC was used in the dissolution media. This may be due to rise in viscosity of the dissolution media. Dose dumping was not noticed under the experimental conditions.

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pH-Sensitive Polymer Blends Used as Coating Materials to Control Drug Release from Spherical Beads: Elucidation of the Underlying Mass Transport Mechanisms

Pharmaceutical Research ◽

10.1007/s11095-005-5421-2 ◽

2005 ◽

Vol 22 (7) ◽

pp. 1129-1141 ◽

Cited By ~ 59

Author(s):

Florence Lecomte ◽

Juergen Siepmann ◽

Mathias Walther ◽

Ross J. MacRae ◽

Roland Bodmeier

Keyword(s):

Drug Release ◽

Mass Transport ◽

Polymer Blends ◽

Ph Sensitive ◽

Transport Mechanisms ◽

Coating Materials ◽

Control Drug ◽

Ph Sensitive Polymer ◽

Mass Transport Mechanisms ◽

Control Drug Release

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Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Soft Matter ◽

10.1039/c7sm01620d ◽

2017 ◽

Vol 13 (41) ◽

pp. 7571-7577 ◽

Cited By ~ 8

Author(s):

Monika Kluzek ◽

Arwen I. I. Tyler ◽

Shiqi Wang ◽

Rongjun Chen ◽

Carlos M. Marques ◽

...

Keyword(s):

Ph Sensitive ◽

Submicron Size ◽

Cubic Phases ◽

Bicontinuous Cubic ◽

Ph Sensitive Polymer

Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers.

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In VivoEvaluation of pH-Sensitive Polymer-Based Immunoliposomes Targeting the CD33 Antigen

Molecular Pharmaceutics ◽

10.1021/mp900261m ◽

2010 ◽

Vol 7 (4) ◽

pp. 1098-1107 ◽

Cited By ~ 30

Author(s):

Pierre Simard ◽

Jean-Christophe Leroux

Keyword(s):

Ph Sensitive ◽

Ph Sensitive Polymer

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Effect of Extracted Microcrystalline Cellulose from Dracaenea arborea Stem on Aceclophenac Tablet Formulation

Journal of Scientific Research and Reports ◽

10.9734/jsrr/2021/v27i130353 ◽

2021 ◽

pp. 107-117

Author(s):

J. I. Ordu ◽

I. E. Udenze

Keyword(s):

Drug Release ◽

Corn Starch ◽

Tablet Formulation ◽

Qualitative Assessment ◽

Crystalline Cellulose ◽

Burst Release ◽

Direct Compression ◽

Drug Release Profile ◽

Compression Technique ◽

Hydration Capacity

Micro crystalline cellulose (MCC) is a major derivative from the bio composite of natural materials such as D. arborea plant stem. It could be useful as a secondary binder and disintegrant in tablet formulation especially following direct compression technique anticipating it to provide high level of disintegration at low use level and utilizing dual mechanisms of wicking and swelling. Tablets of aceclofenac a BCS class II and non steroidal anti inflammatory drug (NSAID) which potently inhibits the cyclo oxygenase enzyme (COX-2) involved in prostaglandin synthesis was formulated by direct compression using MCC from D. arborea stem. Qualitative assessment of the plant extract was carried out and the presence of cellulose confirmed by the appearance of violet – blue coloration while the physicochemical and physicotechnical properties were comparatively evaluated with reference to avicel and corn starch. Three batches of aceclofenac tablets involving Batch A (D. arborea MCC), Batch B (Corn starch) and Batch C (Corn starch and D. arborea MCC in a 1:1 ratio), were implcated in the formulation. Physicochemical study of the MCC reveals a pH of 7.8, mean swelling index 1.14±0.05 ml and hydration capacity of 3.60±0.15 g while the pH of corn starch is 3.90 with swelling and hydration capacity at 5.09±0.03 ml and 8.26±0.01 g respectively. Quality control evaluation of resulting tablet was investigated and the wetting time of batch A tablets was 1.50, batch B 2.30 and batch C 1.80 with percentage moisture content (%) of 60.5, 56.56 and 57.8 and disintegration time (minutes) of 0.22±0.07, 0.35±0.051 and 1.60±0.286 respectively. The drug release profile of batch A, reveals an initial burst release within 10 minutes followed by gradual release while batch C had consistent drug release which was maintained although faster than that of batch A after 10 minutes but batch B had the least drug release rate.

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Controlled Release of Model Substances from pH-Sensitive Hydrogels

Journal of the Mexican Chemical Society ◽

10.29356/jmcs.v52i4.1132 ◽

2019 ◽

Vol 52 (4) ◽

Cited By ~ 1

Author(s):

David Quintanar-Guerrero ◽

Briza Nadyr Zorraquín-Cornejo ◽

Adriana Ganem-Rondero ◽

Elizabeth Piñón-Segundo ◽

María Guadalupe Nava-Arzaluz ◽

...

Keyword(s):

Crystal Form ◽

Ph Sensitive ◽

Cross Linking ◽

Blue Dye ◽

Dissolution Medium ◽

Scanning Calorimetry ◽

Ph Values ◽

Model Substances ◽

Hydrophilic Compound ◽

Higuchi Model

pH-Sensitive hydrogels of the poly(methacrylic acid-comethyl methacrylate) (MAA/MMA) type, 22/78 molar % with different cross-linking percentages (0.3 and 0.5%) were synthesized. These gels were loaded with a model hydrophilic compound (dichlorobromophenol blue dye, DCBFB) with the aim of evaluating its release at different pH values (1.2, 5.0, 6.8, 7.4). The swelling degree and the release from these hydrogels are highly dependent on the pH of the dissolution medium and on the cross-linking degree. Scanning electron microscopy and differential scanning calorimetry studies demonstrated that part of the dye is embedded in crystal form within the hydrogel. The release profiles of the hydrogels assessed at pH = 6.8 and 7.4 were adjusted to the Higuchi model, regarding them asmatrix delivery systems.

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Formulation, Development and Evaluation of Bilayer Floating Tablet of Gemfibrozil

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i4-s.3401 ◽

2019 ◽

Vol 9 (4) ◽

pp. 574-578

Author(s):

Mohammad Faizan Mohammad Gufran ◽

Sailesh Kumar Ghatuary ◽

Reena Shende ◽

Prabhat Kumar Jain ◽

Geeta Parkhe

Keyword(s):

Drug Release ◽

Sustained Release ◽

Hydroxypropyl Methylcellulose ◽

Immediate Release ◽

In Vitro Dissolution ◽

Log P ◽

Physical Parameters ◽

Direct Compression ◽

Formulation Development ◽

Compression Technique

Formulation development is an important part of drug design and development. Bioavailability and bioequivalence are totally dependent on formulation development. Now-a-days formulation development is done by following QbD (Quality by Design).The aim of present study is to formulate Gemfibrozil (Gem) sustained release (SR) and immediate release (IR) bilayer tablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and HPMC K 100 M to control the release pattern. The sustained release layer of Gem was prepared by using different grades of HPMC like, HPMC K-15, HPMC K-4 along with other excipients by direct compression technique. The immediate release layer of Gem was prepared by Cross carmellose sodium, Crospovidone and Sodium starch glycolate by direct compression technique. The powders were evaluated for their flow properties and the finished tablets were evaluated for their physical parameters. The both immediate release and sustained release layers of Gem were characterized by FT-IR and in vitro dissolution studies. The drug release study of Gem was evaluated using USP-II paddle type dissolution apparatus. The release rate of Gem in immediate release layer was studied for 15 min in 0.1 N HCL media and that of Gem in sustained release layer was studied for 12 h in 0.1 N HCL. From the nine batches F6 batch showed good release behaviour 99.85% of drug is released over 12 hours. Gem belongs to BCS Class II (log P 3.6) with poor solubility and high permeability resulting in limited and variable bioavailability. Total four trial batches of each drug have been manufactured to optimize and develop a robust and stable formulation, the stability studies of the products also comply with ICH guideline. Keywords: Bilayer floating tablets, Gemfibrozil, Biphasic drug release, HPMC K 15.

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