Classification of miRNA-related sequence variations

Epigenomics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 463-481 ◽  
Author(s):  
Karin Hrovatin ◽  
Tanja Kunej
Keyword(s):  
Related Sequence ◽  
Sequence Variations

scholarly journals MicroRNA-related sequence variations in human cancers

2013 ◽  
Vol 133 (4) ◽  
pp. 463-469 ◽  
Author(s):  
A. Wojcicka ◽  
A. de la Chapelle ◽  
K. Jazdzewski
Keyword(s):  
Related Sequence ◽  
Human Cancers ◽  
Sequence Variations

scholarly journals Equilibrium sequences of differentially rotating stars with post-merger-like rotational profiles

2021 ◽  
Author(s):  
Panagiotis Iosif ◽  
Nikolaos Stergioulas
Keyword(s):  
Axial Ratio ◽  
Detailed Comparison ◽  
Rotating Stars ◽  
Binary Neutron Star ◽  
Small Influence ◽  
Sequence Variations ◽  
General Relativistic ◽  
Structure Equations ◽  
Type C

Abstract We present equilibrium sequences of rotating relativistic stars, constructed with a new rotation law that was proposed by Uryu et al. (2017). We choose rotational parameters motivated by simulations of binary neutron star merger remnants, but otherwise adopt a cold, relativistic N = 1 polytropic EOS, in order to perform a detailed comparison to published equilibrium sequences that used the Komatsu, Eriguchi and Hachisu (1989) rotation law. We find a small influence of the choice of rotation law on the mass of the equilibrium models and a somewhat larger influence on their radius. The versatility of the new rotation law allows us to construct models that have a similar rotational profile and axial ratio as observed for merger remnants, while at the same time being quasi-spherical. More specifically, we construct equilibrium sequence variations with different degrees of differential rotation and identify type A and type C solutions, similar to the corresponding types in the classification of Ansorg, Gondek-Rosińska and Villain (2009). While our models are highly accurate solutions of the fully general relativistic structure equations, we demonstrate that for models relevant to merger remnants the IWM-CFC approximation still maintains an acceptable accuracy.

scholarly journals Haplogroup Classification of Korean Cattle Breeds Based on Sequence Variations of mtDNA Control Region

2016 ◽  
Vol 29 (5) ◽  
pp. 624-630 ◽  
Author(s):  
Jae-Hwan Kim ◽  
Seong-Su Lee ◽  
Seung Chang Kim ◽  
Seong-Bok Choi ◽  
Su-Hyun Kim ◽  
...  
Keyword(s):  
Control Region ◽  
Mtdna Control Region ◽  
Korean Cattle ◽  
Cattle Breeds ◽  
Sequence Variations

scholarly journals MC1R gene variants involvement in human OCA phenotype

2016 ◽  
Vol 11 (1) ◽  
pp. 142-150 ◽  
Author(s):  
Shamim Saleha ◽  
Taj Ali Khan ◽  
Shaista Zafar
Keyword(s):  
Genetic Disorder ◽  
Oculocutaneous Albinism ◽  
Review Article ◽  
Gene Variants ◽  
Melanin Synthesis ◽  
Comprehensive Description ◽  
Mc1r Gene ◽  
Sequence Variations

AbstractOculocutaneous albinism (OCA) is a genetic disorder of melanin synthesis that results in hypopigmentation in hair, skin and eyes. OCA has been reported in individuals from all ethnic backgrounds but it is more common among those with Europeans ancestry. OCA is heterogeneous group of disorders and seven types of OCA are caused by mutations in TYR (OCA1), OCA2 (OCA2), TYRP1 (OCA3), SLC45A2 (OCA4), SLC24A5 (OCA6) and C10oRF11 (OCA7) genes. However, MC1R gene variants have been reported that modify OCA2 phenotype but the knowledge about the function ofMC1R gene in melanogenesis, and genotype-phenotype association, in case of OCA, is limited. In this review article we present a comprehensive description of classification of OCA, role of MSH-R in melanin synthesis, the sequence variations in MC1R and their association with OCA. This review will enhance our understanding of MC1R gene variants involved in human OCA2 phenotype.

scholarly journals The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Viviane Corrêa Santos ◽  
Antonio Edson Rocha Oliveira ◽  
Augusto César Broilo Campos ◽  
João Luís Reis-Cunha ◽  
Daniella Castanheira Bartholomeu ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Active Sites ◽  
Protozoan Parasite ◽  
Cysteine Proteases ◽  
Gene Repertoire ◽  
Parasite Life Cycle ◽  
Sequence Variations ◽  
Multigenic Family ◽  
Parasite Strains

AbstractCruzipains are the main papain-like cysteine proteases of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease. Encoded by a multigenic family, previous studies have estimated the presence of dozens of copies spread over multiple chromosomes in different parasite strains. Here, we describe the complete gene repertoire of cruzipain in three parasite strains, their genomic organization, and expression pattern throughout the parasite life cycle. Furthermore, we have analyzed primary sequence variations among distinct family members as well as structural differences between the main groups of cruzipains. Based on phylogenetic inferences and residue positions crucial for enzyme function and specificity, we propose the classification of cruzipains into two families (I and II), whose genes are distributed in two or three separate clusters in the parasite genome, according with the strain. Family I comprises nearly identical copies to the previously characterized cruzipain 1/cruzain, whereas Family II encompasses three structurally distinct sub-types, named cruzipain 2, cruzipain 3, and cruzipain 4. RNA-seq data derived from the CL Brener strain indicates that Family I genes are mainly expressed by epimastigotes, whereas trypomastigotes mainly express Family II genes. Significant differences in the active sites among the enzyme sub-types were also identified, which may play a role in their substrate selectivity and impact their inhibition by small molecules.

scholarly journals The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites

2021 ◽  
Author(s):  
Viviane Corrêa Santos ◽  
Antonio Edson Rocha Oliveira ◽  
Augusto César Broilo Campos ◽  
João Luís Reis-Cunha ◽  
Daniella Castanheira Bartholomeu ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Active Sites ◽  
Protozoan Parasite ◽  
Cysteine Proteases ◽  
Gene Repertoire ◽  
Parasite Life Cycle ◽  
Sequence Variations ◽  
Multigenic Family ◽  
Parasite Strains

Abstract Cruzipains are the main papain-like cysteine proteases of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease. Encoded by a multigenic family, previous studies have estimated the presence of dozens of copies spread over multiple chromosomes in different parasite strains. Here, we describe the complete gene repertoire of cruzipain in three parasite strains, their genomic organization, and expression pattern throughout the parasite life cycle. Furthermore, we have analyzed primary sequence variations among distinct family members as well as structural differences between the main groups of cruzipains. Based on phylogenetic inferences and residue positions crucial for enzyme function and specificity, we propose the classification of cruzipains into two families (I and II), whose genes are distributed in two or three separate clusters in the parasite genome, according with the strain. Family I comprises nearly identical copies to the previously characterized cruzipain 1/cruzain, whereas Family II encompasses three structurally distinct sub-types, named cruzipain 2, cruzipain 3, and cruzipain 4. RNA-seq data derived from the CL Brener strain indicates that Family I genes are mainly expressed by epimastigotes, whereas trypomastigotes mainly express Family II genes. Significant differences in the active sites among the enzyme sub-types were also identified, which may play a role in their substrate selectivity and impact their inhibition by small molecules.

scholarly journals Correlation between gyrA and CmeR Box Polymorphism and Fluoroquinolone Resistance in Campylobacter jejuni Isolates in China

2017 ◽  
Vol 61 (7) ◽  
Author(s):  
Tengfei Zhang ◽  
Yiluo Cheng ◽  
Qingping Luo ◽  
Qin Lu ◽  
Jun Dong ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Campylobacter Jejuni ◽  
Fluoroquinolone Resistance ◽  
Related Sequence ◽  
Content Type ◽  
Sequence Variations

ABSTRACT Sequence analysis of 79 ciprofloxacin-resistant Campylobacter jejuni isolates collected in China showed resistance-related sequence variations in gyrA and CmeR-Box. All the isolates contain an identical Thr-86-Ile substitution in GyrA. Several novel CmeR-Box variations, including point substitutions, deletion, and insertion, were identified. The point insertion or deletion led to dramatically reduced binding of CmeR to the cmeABC promoter, which significantly increases the expression of cmeABC and contributes to the high fluoroquinolone resistance.

Classification of hepatitis C virus into subgroups on the basis of sequence variations in the envelope protein

1993 ◽  
Vol 8 (S1) ◽  
pp. S70-S74
Author(s):  
H. HADA ◽  
N. KOIDE ◽  
T. HANAFUSA ◽  
H. TAKABATAKE ◽  
K. SAKAGUCHI ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Protein ◽  
Sequence Variations

Note on the spectral classification of carbon stars in the photographic infrared region

1966 ◽  
Vol 24 ◽  
pp. 21-23
Author(s):  
Y. Fujita
Keyword(s):  
Infrared Region ◽  
Spectral Classification ◽  
Carbon Stars

We have investigated the spectrograms (dispersion: 8Å/mm) in the photographic infrared region fromλ7500 toλ9000 of some carbon stars obtained by the coudé spectrograph of the 74-inch reflector attached to the Okayama Astrophysical Observatory. The names of the stars investigated are listed in Table 1.

Sign in / Sign up

Export Citation Format

Share Document