Germline genetic markers for urinary bladder cancer risk, prognosis and treatment response

2010 ◽  
Vol 6 (9) ◽  
pp. 1433-1460 ◽  
Author(s):  
Anne J Grotenhuis ◽  
Sita H Vermeulen ◽  
Lambertus A Kiemeney
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Cancer Risk ◽  
Treatment Response ◽  
Genetic Markers ◽  
Urinary Bladder Cancer ◽  
Bladder Cancer Risk ◽  
Risk Prognosis

Polymorphic Enzymes, Urinary Bladder Cancer Risk, and Structural Change in the Local Industry

2012 ◽  
Vol 75 (8-10) ◽  
pp. 557-565 ◽  
Author(s):  
Daniel Ovsiannikov ◽  
Silvia Selinski ◽  
Marie-Louise Lehmann ◽  
Meinolf Blaszkewicz ◽  
Oliver Moormann ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Structural Change ◽  
Urinary Bladder ◽  
Cancer Risk ◽  
Urinary Bladder Cancer ◽  
Bladder Cancer Risk ◽  
Polymorphic Enzymes

scholarly journals Urinary Bladder Cancer Risk Factors in Egypt: A Multicenter Case–Control Study

2011 ◽  
Vol 21 (3) ◽  
pp. 537-546 ◽  
Author(s):  
Yun-Ling Zheng ◽  
Sania Amr ◽  
Doa'a A. Saleh ◽  
Chiranjeev Dash ◽  
Sameera Ezzat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bladder Cancer ◽  
Urinary Bladder ◽  
Cancer Risk ◽  
Case Control Study ◽  
Urinary Bladder Cancer ◽  
Case Control ◽  
Bladder Cancer Risk ◽  
Cancer Risk Factors ◽  
Control Study

scholarly journals Agricultural Workers and Urinary Bladder Cancer Risk in Egypt

2013 ◽  
Vol 69 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Sania Amr ◽  
Rebecca Dawson ◽  
Doa'a A. Saleh ◽  
Laurence S. Magder ◽  
Nabiel N. Mikhail ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Cancer Risk ◽  
Urinary Bladder Cancer ◽  
Agricultural Workers ◽  
Bladder Cancer Risk

scholarly journals Bilirubin is not associated with urinary bladder cancer risk and prognosis: A Mendelian Randomization Study in the UK Biobank

2020 ◽  
Author(s):  
Nadezda Lipunova ◽  
Richard T Bryan ◽  
Maurice P Zeegers
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Smoking Status ◽  
Urinary Bladder Cancer ◽  
Potential Effect ◽  
Uk Biobank ◽  
Bladder Cancer Risk ◽  
The Uk

Mutations in UGT1A gene have been associated with the development and prognosis of urinary bladder cancer (UBC). UGT1A proteins are involved in a spectrum of detoxification processes, hence the biological mechanism between UGT1A and UBC is difficult to elucidate. Concurrently, mild hyperbilirubinemia, caused by alterations in UGT1A, has been associated with multiple health outcomes. We have investigated the potential effect of mild hyperbilirubinemia on UBC risk and prognosis, using a Mendelian Randomization (MR) approach in the UK Biobank. Data on 1,281 UBC patients and 4,071 controls was available for a two-stage least squares MR estimation with rs6742078 as an instrumental variable. First, linear regression was fitted to establish the relationship between the rs6742078 and bilirubin levels (total and unconjugated). Secondly, bilirubin values were used to predict tested outcomes under a logistic model. Both stages were adjusted for participant sex, smoking status, and age. MR analysis showed no significant effects of bilirubin levels on UBC risk (total bilirubin: OR=1.02, 95% CI: 0.99-1.04; unconjugated bilirubin: OR=1.02, 95% CI: 0.99-1.05). No effects were observed for events of UBC recurrence, progression, or survival. Our study suggests mild hyperbilirubinemia is not associated with urinary bladder cancer risk and prognosis.

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