Expression of IGF-1 receptor in KIT/PDGF receptor-α wild-type gastrointestinal stromal tumors with succinate dehydrogenase complex dysfunction

2013 ◽  
Vol 9 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Margherita Nannini ◽  
Annalisa Astolfi ◽  
Paola Paterini ◽  
Milena Urbini ◽  
Donatella Santini ◽  
...  
Keyword(s):  
Succinate Dehydrogenase ◽  
Gastrointestinal Stromal Tumors ◽  
Pdgf Receptor ◽  
Wild Type ◽  
Stromal Tumors ◽  
Succinate Dehydrogenase Complex ◽  
Dehydrogenase Complex

scholarly journals Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors: Small Steps Toward Personalized Medicine?

2019 ◽  
Vol 12 ◽  
pp. 251686571984253 ◽  
Author(s):  
Gloria Ravegnini ◽  
Riccardo Ricci
Keyword(s):  
Succinate Dehydrogenase ◽  
Gastrointestinal Stromal Tumors ◽  
Dna Methyltransferase ◽  
Kinase Inhibitors ◽  
Alkylating Agents ◽  
Mgmt Methylation ◽  
Wild Type ◽  
Stromal Tumors ◽  
Methylguanine Dna Methyltransferase ◽  
Specific Alternative

Various molecular triggers define heterogeneous subsets of gastrointestinal stromal tumors (GISTs), differing in clinical behavior and drug sensitivity. KIT/PDGFRA-wild-type GISTs, including those succinate dehydrogenase (SDH)-deficient, are overall unresponsive to the tyrosine kinase inhibitors commonly used, fostering the development of specific alternative therapeutic strategies. Epigenetic inactivation of O6-methylguanine-DNA methyltransferase (MGMT) through promoter methylation leads to effectiveness of alkylating agents in several human cancers. SDH-deficient GISTs typically feature widespread DNA methylation. However, the actual occurrence of MGMT methylation in these tumors, potentially predisposing them to respond to alkylating drugs, has not been investigated so far. Here we discuss the recent findings concerning the occurrence of MGMT methylation in different GIST subgroups, including SDH-deficient ones, as a premise for a possible reappraisal of alkylating agents specifically targeting these small, otherwise overall chemorefractory, GIST subgroups.

scholarly journals Analysis of all subunits, SDHA, SDHB, SDHC, SDHD, of the succinate dehydrogenase complex in KIT/PDGFRA wild-type GIST

2013 ◽  
Vol 22 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Maria A Pantaleo ◽  
◽  
Annalisa Astolfi ◽  
Milena Urbini ◽  
Margherita Nannini ◽  
...  
Keyword(s):  
Succinate Dehydrogenase ◽  
Wild Type ◽  
Succinate Dehydrogenase Complex ◽  
Dehydrogenase Complex

Succinate dehydrogenase in KIT/PDGFRA wild-type gastrointestinal stromal tumors.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 10008-10008 ◽  
Author(s):  
K. A. Janeway ◽  
S. Kim ◽  
M. Lodish ◽  
V. Nose ◽  
P. Dahia ◽  
...  
Keyword(s):  
Succinate Dehydrogenase ◽  
Gastrointestinal Stromal Tumors ◽  
Wild Type ◽  
Stromal Tumors
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