Variability in clinical and biological response to rituximab in autoimmune diseases: an opportunity for personalized therapy?

Venkat Reddy; Maria Leandro

doi:10.2217/ijr.14.18

Variability in clinical and biological response to rituximab in autoimmune diseases: an opportunity for personalized therapy?

International Journal of Clinical Rheumatology ◽

10.2217/ijr.14.18 ◽

2014 ◽

Vol 9 (3) ◽

pp. 279-293 ◽

Cited By ~ 3

Author(s):

Venkat Reddy ◽

Maria Leandro

Keyword(s):

Autoimmune Diseases ◽

Biological Response ◽

Personalized Therapy

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Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

Journal of Histochemistry & Cytochemistry ◽

10.1369/0022155420930303 ◽

2020 ◽

Vol 68 (12) ◽

pp. 887-906

Author(s):

Jinyang Zeng-Brouwers ◽

Sony Pandey ◽

Jonel Trebicka ◽

Malgorzata Wygrecka ◽

Liliana Schaefer

Keyword(s):

Autoimmune Diseases ◽

Biological Response ◽

Innate Immune ◽

Inflammatory Signaling ◽

Aseptic Inflammation ◽

Immune Receptors ◽

Specific Manner ◽

Inflammatory Processes ◽

Molecular Specificity ◽

Fine Tune

Inflammation is a highly regulated biological response of the immune system that is triggered by assaulting pathogens or endogenous alarmins. It is now well established that some soluble extracellular matrix constituents, such as small leucine-rich proteoglycans (SLRPs), can act as danger signals and trigger aseptic inflammation by interacting with innate immune receptors. SLRP inflammatory signaling cascade goes far beyond its canonical function. By choosing specific innate immune receptors, coreceptors, and adaptor molecules, SLRPs promote a switch between pro- and anti-inflammatory signaling, thereby determining disease resolution or chronification. Moreover, by orchestrating signaling through various receptors, SLRPs fine-tune inflammation and, despite their structural homology, regulate inflammatory processes in a molecule-specific manner. Hence, the overarching theme of this review is to highlight the molecular and functional specificity of biglycan-, decorin-, lumican-, and fibromodulin-mediated signaling in inflammatory and autoimmune diseases

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Association Between −174 Interleukin-6 Gene Polymorphism and Biological Response to Rituximab in Several Systemic Autoimmune Diseases

DNA and Cell Biology ◽

10.1089/dna.2012.1684 ◽

2012 ◽

Vol 31 (9) ◽

pp. 1486-1491 ◽

Cited By ~ 13

Author(s):

Gema Robledo ◽

Cristina Lucía Dávila-Fajardo ◽

Ana Márquez ◽

Norberto Ortego-Centeno ◽

José Luis Callejas Rubio ◽

...

Keyword(s):

Gene Polymorphism ◽

Autoimmune Diseases ◽

Interleukin 6 ◽

Biological Response ◽

Systemic Autoimmune Diseases

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Laryngeal Manifestations of Autoimmune Diseases

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2020_persp-19-00168 ◽

2020 ◽

Vol 5 (2) ◽

pp. 439-456

Author(s):

Jenny L. Pierce

Keyword(s):

Autoimmune Disease ◽

Autoimmune Diseases ◽

Patient Outcomes ◽

Correct Diagnosis ◽

Upper Airway ◽

Clinical Implications ◽

Laryngeal Function ◽

The Past ◽

Referral Practices ◽

Timely Referral

Purpose This review article provides an overview of autoimmune diseases and their effects on voice and laryngeal function. Method A literature review was conducted in PubMed. Combinations of the following keywords were used: “autoimmune disease and upper airway,” “larynx,” “cough,” “voice,” “dysphonia,” and “dyspnea.” Precedence was given to articles published in the past 10 years due to recent advances in this area and to review articles. Ultimately, 115 articles were included for review. Results Approximately 81 autoimmune diseases exist, with 18 of those highlighted in the literature as having laryngeal involvement. The general and laryngeal manifestations of these 18 are discussed in detail, in addition to the clinical implications for a laryngeal expert. Conclusions Voice, breathing, and cough symptoms may be an indication of underlying autoimmune disease. However, these symptoms are often similar to those in the general population. Appropriate differential diagnosis and timely referral practices maximize patient outcomes. Guidelines are provided to facilitate correct diagnosis when an autoimmune disease is suspected.

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