Carbon dots from an immunomodulatory plant for cancer cell imaging, free radical scavenging and metal sensing applications

Nanomedicine ◽  
2021 ◽  
Vol 16 (23) ◽  
pp. 2039-2059
Author(s):  
Debadatta Mohapatra ◽  
Md. Bayazeed Alam ◽  
Vivek Pandey ◽  
Ravi Pratap ◽  
Pawan K Dubey ◽  
...  
Keyword(s):  
Free Radical ◽  
Cancer Cell ◽  
Carbon Dots ◽  
Cell Imaging ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Tinospora Cordifolia ◽  
Cancer Cell Imaging ◽  
Sensing Applications ◽  
Metal Sensing

Aim: This work aimed to develop Tinospora cordifolia stem-derived carbon dots (TCSCD) for cancer cell imaging, free radical scavenging and metal sensing applications. Method: The TCSCDs were synthesized by a simple, one-step, and ecofriendly hydrothermal carbonization method and characterized for their optical properties, morphology, hydrodynamic size, surface functionality, crystallinity, stability, bacterial biocompatibility, in vitro cellular imaging, free radical scavenging and metal sensing ability. Results: The TCSCDs exhibited excellent biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. They exerted good free radical scavenging, Fe3+ sensing, bacterial biocompatibility, photostability, colloidal dispersion stability and thermal stability. Conclusion: The results reflect the potential of TCSCDs for biomedical and pharmaceutical applications.

scholarly journals Tinospora Cordifolia Leaves Derived Carbon Dots For Cancer Cell Bioimaging, Free Radical Scavenging, And Fe3+ Sensing Applications

2021 ◽  
Author(s):  
Debadatta Mohapatra ◽  
Ravi Pratap ◽  
Vivek Pandey ◽  
Pawan K. Dubey ◽  
Ashish K. Agrawal ◽  
...  
Keyword(s):  
Free Radical ◽  
Cancer Cell ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Tinospora Cordifolia ◽  
X Ray ◽  
Ion Sensing ◽  
Sensing Applications

Abstract Herein, we report the fabrication of Tinospora cordifolia leaves-derived carbon dots (TCLCDs) from aqueous extract of leaves as carbon source via simple, environmental friendly, hydrothermal carbonization (HTC) technique. The synthesized TCLCDs were characterized for their physicochemical properties and further explored for in-vitro cancer cell bioimaging, radical scavenging, and metal ion sensing. The synthesized TCLCDs showed excitation-dependent emission property with maximum emission at 435 nm under the excitation of 350 nm. The High-Resolution Transmission Electron Microscopy (HRTEM) results revealed a roughly spherical shape with an average diameter of 5.47 nm. The diffused ring pattern of Selected Area Electron Diffraction (SAED) and halo diffraction pattern of X-ray diffraction (XRD) disclosed their amorphous nature. The Energy Dispersive X-ray (EDX) showed the existence of C, N, and O. The Fourier-transform infrared spectroscopy (FTIR) revealed the presence of -OH, -NH, -CN, and -CH groups. The TCLCDs showed excellent cellular biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. Also, they exhibited excellent scavenging of free radicals with an IC50 value of 0.524 mg/mL & selective Fe3+ ion sensing with a detection limit of 0.414 µM. Further, they exerted excellent bacterial biocompatibility, photostability, and thermal stability. The overall results reflected their potential for in-vitro cancer cell bioimaging, free radical scavenging, and selective Fe3+ ion sensing.

Sand bath assisted green synthesis of carbon dots from citrus fruit peels for free radical scavenging and cell imaging

2021 ◽  
Vol 197 ◽  
pp. 111362
Author(s):  
Krishna Kanthi Gudimella ◽  
Tejaswini Appidi ◽  
Hui-Fen Wu ◽  
Venkateswararao Battula ◽  
Anil Jogdand ◽  
...  
Keyword(s):  
Free Radical ◽  
Green Synthesis ◽  
Carbon Dots ◽  
Cell Imaging ◽  
Radical Scavenging ◽  
Citrus Fruit ◽  
Free Radical Scavenging ◽  
Sand Bath

Superior reducing carbon dots from proanthocyanidin for free-radical scavenging and for cell imaging

The Analyst ◽  
2021 ◽  
Author(s):  
Dian Yang ◽  
Li Li ◽  
Lei Cao ◽  
Yan Zhang ◽  
Mingfeng Ge ◽  
...  
Keyword(s):  
Free Radical ◽  
Human Body ◽  
Carbon Dots ◽  
Cell Imaging ◽  
Radical Scavenging ◽  
Free Radical Scavenging

The presence of excessive ROS can cause much harm to the human body and can even cause diseases.

Heteroatom Doped Carbon Dots with Nanoenzyme Like Properties as Theranostic Platforms for Free Radical Scavenging, Imaging, and Chemotherapy

2020 ◽  
Author(s):  
Khalilalrahman Dehvari ◽  
Sheng-Hui Chiu ◽  
Jin-Sheng Lin ◽  
Wubshet Mekonnen Girm ◽  
Yong-Chien Ling ◽  
...  
Keyword(s):  
Free Radical ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Doped Carbon Dots

Studies on free radical scavenging, cancer cell antiproliferation, and calf thymus DNA interaction of Schiff bases

2017 ◽  
Vol 172 ◽  
pp. 129-138 ◽  
Author(s):  
Cleiton M. da Silva ◽  
Marina M. Silva ◽  
Fabiano S. Reis ◽  
Ana Lúcia T.G. Ruiz ◽  
João E. de Carvalho ◽  
...  
Keyword(s):  
Free Radical ◽  
Schiff Bases ◽  
Cancer Cell ◽  
Radical Scavenging ◽  
Dna Interaction ◽  
Free Radical Scavenging ◽  
Calf Thymus Dna ◽  
Calf Thymus

A carbon dot based theranostic platform for dual-modal imaging and free radical scavenging

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20917-20931 ◽  
Author(s):  
Jin-Sheng Lin ◽  
Yi-Wen Tsai ◽  
Khalilalrahman Dehvari ◽  
Chih-Ching Huang ◽  
Jia-Yaw Chang
Keyword(s):  
Free Radical ◽  
Mr Imaging ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Carbon Dot

Red emitting carbon dots with phosphorus and manganese dopants were explored for synergistic in vitro fluorescence/MR imaging and cytoprotective effects.

Synthesis of Ultrasmall and Monodisperse Selenium-Doped Carbon Dots from Amino Acids for Free Radical Scavenging

2020 ◽  
Vol 59 (38) ◽  
pp. 16876-16883
Author(s):  
Rina Su ◽  
Jie Shi ◽  
Yuan Pu ◽  
Jie-Xin Wang ◽  
Dan Wang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Free Radical ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Doped Carbon Dots
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