scholarly journals Tinospora cordifolia Leaves Derived Carbon dots for Cancer Cell Bioimaging, Free radical Scavenging, and Fe3+ Sensing Applications

2021 ◽  
Author(s):  
Debadatta Mohapatra ◽  
Ravi Pratap ◽  
Vivek Pandey ◽  
Pawan K. Dubey ◽  
Ashish K. Agrawal ◽  
...  
Keyword(s):  
Free Radical ◽  
Cancer Cell ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Tinospora Cordifolia ◽  
Sensing Applications

Carbon dots from an immunomodulatory plant for cancer cell imaging, free radical scavenging and metal sensing applications

Nanomedicine ◽  
2021 ◽  
Vol 16 (23) ◽  
pp. 2039-2059
Author(s):  
Debadatta Mohapatra ◽  
Md. Bayazeed Alam ◽  
Vivek Pandey ◽  
Ravi Pratap ◽  
Pawan K Dubey ◽  
...  
Keyword(s):  
Free Radical ◽  
Cancer Cell ◽  
Carbon Dots ◽  
Cell Imaging ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Tinospora Cordifolia ◽  
Cancer Cell Imaging ◽  
Sensing Applications ◽  
Metal Sensing

Aim: This work aimed to develop Tinospora cordifolia stem-derived carbon dots (TCSCD) for cancer cell imaging, free radical scavenging and metal sensing applications. Method: The TCSCDs were synthesized by a simple, one-step, and ecofriendly hydrothermal carbonization method and characterized for their optical properties, morphology, hydrodynamic size, surface functionality, crystallinity, stability, bacterial biocompatibility, in vitro cellular imaging, free radical scavenging and metal sensing ability. Results: The TCSCDs exhibited excellent biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. They exerted good free radical scavenging, Fe3+ sensing, bacterial biocompatibility, photostability, colloidal dispersion stability and thermal stability. Conclusion: The results reflect the potential of TCSCDs for biomedical and pharmaceutical applications.

scholarly journals Tinospora Cordifolia Leaves Derived Carbon Dots For Cancer Cell Bioimaging, Free Radical Scavenging, And Fe3+ Sensing Applications

2021 ◽  
Author(s):  
Debadatta Mohapatra ◽  
Ravi Pratap ◽  
Vivek Pandey ◽  
Pawan K. Dubey ◽  
Ashish K. Agrawal ◽  
...  
Keyword(s):  
Free Radical ◽  
Cancer Cell ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Tinospora Cordifolia ◽  
X Ray ◽  
Ion Sensing ◽  
Sensing Applications

Abstract Herein, we report the fabrication of Tinospora cordifolia leaves-derived carbon dots (TCLCDs) from aqueous extract of leaves as carbon source via simple, environmental friendly, hydrothermal carbonization (HTC) technique. The synthesized TCLCDs were characterized for their physicochemical properties and further explored for in-vitro cancer cell bioimaging, radical scavenging, and metal ion sensing. The synthesized TCLCDs showed excitation-dependent emission property with maximum emission at 435 nm under the excitation of 350 nm. The High-Resolution Transmission Electron Microscopy (HRTEM) results revealed a roughly spherical shape with an average diameter of 5.47 nm. The diffused ring pattern of Selected Area Electron Diffraction (SAED) and halo diffraction pattern of X-ray diffraction (XRD) disclosed their amorphous nature. The Energy Dispersive X-ray (EDX) showed the existence of C, N, and O. The Fourier-transform infrared spectroscopy (FTIR) revealed the presence of -OH, -NH, -CN, and -CH groups. The TCLCDs showed excellent cellular biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. Also, they exhibited excellent scavenging of free radicals with an IC50 value of 0.524 mg/mL & selective Fe3+ ion sensing with a detection limit of 0.414 µM. Further, they exerted excellent bacterial biocompatibility, photostability, and thermal stability. The overall results reflected their potential for in-vitro cancer cell bioimaging, free radical scavenging, and selective Fe3+ ion sensing.

Heteroatom Doped Carbon Dots with Nanoenzyme Like Properties as Theranostic Platforms for Free Radical Scavenging, Imaging, and Chemotherapy

2020 ◽  
Author(s):  
Khalilalrahman Dehvari ◽  
Sheng-Hui Chiu ◽  
Jin-Sheng Lin ◽  
Wubshet Mekonnen Girm ◽  
Yong-Chien Ling ◽  
...  
Keyword(s):  
Free Radical ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Doped Carbon Dots

Studies on free radical scavenging, cancer cell antiproliferation, and calf thymus DNA interaction of Schiff bases

2017 ◽  
Vol 172 ◽  
pp. 129-138 ◽  
Author(s):  
Cleiton M. da Silva ◽  
Marina M. Silva ◽  
Fabiano S. Reis ◽  
Ana Lúcia T.G. Ruiz ◽  
João E. de Carvalho ◽  
...  
Keyword(s):  
Free Radical ◽  
Schiff Bases ◽  
Cancer Cell ◽  
Radical Scavenging ◽  
Dna Interaction ◽  
Free Radical Scavenging ◽  
Calf Thymus Dna ◽  
Calf Thymus

A carbon dot based theranostic platform for dual-modal imaging and free radical scavenging

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20917-20931 ◽  
Author(s):  
Jin-Sheng Lin ◽  
Yi-Wen Tsai ◽  
Khalilalrahman Dehvari ◽  
Chih-Ching Huang ◽  
Jia-Yaw Chang
Keyword(s):  
Free Radical ◽  
Mr Imaging ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Carbon Dot

Red emitting carbon dots with phosphorus and manganese dopants were explored for synergistic in vitro fluorescence/MR imaging and cytoprotective effects.

Synthesis of Ultrasmall and Monodisperse Selenium-Doped Carbon Dots from Amino Acids for Free Radical Scavenging

2020 ◽  
Vol 59 (38) ◽  
pp. 16876-16883
Author(s):  
Rina Su ◽  
Jie Shi ◽  
Yuan Pu ◽  
Jie-Xin Wang ◽  
Dan Wang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Free Radical ◽  
Carbon Dots ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Doped Carbon Dots

scholarly journals Free Radical Scavenging and In vitro Cytotoxic Activity of Bugnay (Antidesma bunius) Leaves Extract against A549 Human Lung Adenocarcinoma and HCT-116 Human Colorectal Cancer Cell Lines

2020 ◽  
Vol 11 (3) ◽  
pp. 124
Author(s):  
Arnold Joseph O. Geronimo ◽  
Mari Erika Joi F. Bancual ◽  
Karl Anthony L. Ko ◽  
Lycon Marie L. Soliba ◽  
Jeric John C. Ildefonso ◽  
...  
Keyword(s):  
Free Radical ◽  
Lung Adenocarcinoma ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Hct 116

Cancer is one of the significant causes of mortality worldwide. Studies on antineoplastic drugs focused on natural products have revealed several mechanisms to inhibit cancer cells. Bugnay (Antidesma bunius) leaves showed potentials due to its activity observed against brine shrimp and breast cancer cells. However, there is still limited knowledge about its activity against other human cancer cells. This study focused on determining the phytochemical compounds in A. bunius leaves extract, the free radical scavenging activity of the extract using the Diphenylpicrylhydrazyl (DPPH) method, and in vitro cytotoxic activity against two cancer cell lines, namely HCT-116 human colorectal and A549 human lung adenocarcinoma cancer cell lines by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The phytochemicals identified were unsaturated lactones, flavonoids, phenolics, diterpenes, saponins, tannins, carbohydrates, and reducing sugars. The extract showed significant free radical scavenging activity and a direct correlation of activity with concentration levels. It also exhibited cytotoxic activity against HCT-116 human colorectal and A549 human lung adenocarcinoma. Hence, A. bunius leaves have the potential to be a source of antioxidant and antineoplastic compounds. This warrant further isolation of the compounds for chemotherapeutic purposes.Keywords: Antidesma bunius, Bugnay, Cancer, Cytotoxicity, Radical

Generation of Neurodegenerative phenotype using Drosophila melanogaster through paraquat treatment and an amelioration by Tinospora cordifolia (giloy)

2021 ◽  
pp. 3056-3062
Author(s):  
Mahendra P. Singh ◽  
Twinkle Twinkle ◽  
Ranjana Himalian
Keyword(s):  
Drosophila Melanogaster ◽  
Free Radical ◽  
Phenolic Content ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Tinospora Cordifolia ◽  
Total Phenolic ◽  
Significant Difference ◽  
Significant Amelioration ◽  
The Impact

Neurodegenerative diseases are non-curable for the modern world and mainly affecting the aged population across the globe. These diseases cause serious issues with compromised motor function and along with dementia. In the present study, we have explored the benefits of Tinospora cordifolia (giloy) against chemical-induced neurodegeneration in wild type Drosophila melanogaster (Oregon R+) also known as fruit fly. We examined the biochemical properties of Tinospora cordifolia (giloy) through phenolic content and antioxidant capacity. The antioxidant activities of giloy were judged by in vitro methods like total phenolic content and DPPH free radical scavenging assay against ascorbic acid as standard. We treated D. melanogaster with paraquat (PQ, 1.0mM and 2.0mM) for 24 and 48 h and after the treatment, neurodegeneration was evaluated through classical methods like locomotor assay and memory assay in fruit flies. Furthermore, we have also checked the impact of paraquat on the total survival of the flies to evaluat lonevity and we evident a significant amelioration in neurodegeneration due to co-treatment of Tinospora cordifolia as compared to paraquat-treated flies. We found an improved toal survival of D. melanogaster in PQ along with Tinospora cordifolia treated groups and evident a significant difference in locomotor as well as in memory assays. Conclusively, we may suggest that Tinospora cordifolia is having good phenolic content and free radical scavenging properties thereby D. melanogaster treated along with giloy exhibited reduced neurodegeneration and showed significant amelioration.

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