Carbon dots from an immunomodulatory plant for cancer cell imaging, free radical scavenging and metal sensing applications

Aim: This work aimed to develop Tinospora cordifolia stem-derived carbon dots (TCSCD) for cancer cell imaging, free radical scavenging and metal sensing applications. Method: The TCSCDs were synthesized by a simple, one-step, and ecofriendly hydrothermal carbonization method and characterized for their optical properties, morphology, hydrodynamic size, surface functionality, crystallinity, stability, bacterial biocompatibility, in vitro cellular imaging, free radical scavenging and metal sensing ability. Results: The TCSCDs exhibited excellent biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. They exerted good free radical scavenging, Fe3+ sensing, bacterial biocompatibility, photostability, colloidal dispersion stability and thermal stability. Conclusion: The results reflect the potential of TCSCDs for biomedical and pharmaceutical applications.

Spectroscopic, Voltammetric, DFT and Molecular Docking Studies of Copper (II) Complex of Carbothiohydrazide Derivative

In this work, the nature of complexation between copper and N′,2-bis((E)-2-hydroxybenzylidene) hydrazine-1-carbothiohydrazide (a promising metal sensing Schiff base with a marked biological activity) (H4L) has been investigated and experimentally characterized. The investigation includes spectroscopic tools as infrared spectra (FT-IR), XRD, thermal analysis (TG) spectra, ultraviolet spectra (UV) in addition to cyclic voltammetric study. Quantum chemical calculations using density functional theory (DFT) used to predict the structural properties of the complex under investigation and to aid in the explanation of the electronic spectra of the complex. In addition to that, the Molecular docking for the complex under investigation with the 2ylh target protein have been conducted in order to check the biological activity of the complex.