scholarly journals Treatment of pulmonary exacerbations in cystic fibrosis

Therapy ◽  
2011 ◽  
Vol 8 (6) ◽  
pp. 623-643 ◽  
Author(s):  
Daniel J Smith ◽  
David W Reid ◽  
Scott C Bell
Keyword(s):  
Cystic Fibrosis ◽  
Pulmonary Exacerbations

scholarly journals Variation in treatment preferences of pulmonary exacerbations among Australian and New Zealand cystic fibrosis physicians

2021 ◽  
Vol 8 (1) ◽  
pp. e000956
Author(s):  
Grace Currie ◽  
Anna Tai ◽  
Tom Snelling ◽  
André Schultz
Keyword(s):  
Cystic Fibrosis ◽  
Clinical Trials ◽  
New Zealand ◽  
Treatment Options ◽  
Early Response ◽  
Treatment Preferences ◽  
Dornase Alfa ◽  
Clinical Scenarios ◽  
Professional Opinion ◽  
Pulmonary Exacerbations

BackgroundDespite advances in cystic fibrosis (CF) management and survival, the optimal treatment of pulmonary exacerbations remains unclear. Understanding the variability in treatment approaches among physicians might help prioritise clinical uncertainties to address through clinical trials.MethodsPhysicians from Australia and New Zealand who care for people with CF were invited to participate in a web survey of treatment preferences for CF pulmonary exacerbations. Six typical clinical scenarios were presented; three to paediatric and another three to adult physicians. For each scenario, physicians were asked to choose treatment options and provide reasons for their choices.ResultsForty-nine CF physicians (31 paediatric and 18 adult medicine) participated; more than half reported 10+ years of experience. There was considerable variation in primary antibiotic selection; none was preferred by more than half of respondents in any scenario. For secondary antibiotic therapy, respondents consistently preferred intravenous tobramycin and a third antibiotic was rarely prescribed, except in one scenario describing an adult patient. Hypertonic saline nebulisation and twice daily chest physiotherapy was preferred in most scenarios while dornase alfa use was more variable. Most CF physicians (>80%) preferred to change therapy if there was no early response. Professional opinion was the most common reason for antibiotic choice.ConclusionsVariation exists among CF physicians in their preferred choice of primary antibiotic and use of dornase alfa. These preferences are driven by professional opinion, possibly reflecting a lack of evidence to base policy recommendations. Evidence from high-quality clinical trials is needed to inform physician decision making.

Aminoglycoside dosing and monitoring for Pseudomonas aeruginosa during acute pulmonary exacerbations in cystic fibrosis

2021 ◽  
Author(s):  
Madeleine A. Ochs ◽  
Nicholas O. Dillman ◽  
Lindsay J. Caverly ◽  
Valerie D. Chaffee
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Pulmonary Exacerbations

Antimicrobial Therapy of Pseudomonas Pulmonary Exacerbations in Cystic Fibrosis.

1986 ◽  
Vol 75 (1) ◽  
pp. 128-138 ◽  
Author(s):  
U. B. SCHAAD ◽  
D. DESGRANDCHAMPS ◽  
R. KRAEMER
Keyword(s):  
Cystic Fibrosis ◽  
Antimicrobial Therapy ◽  
Pulmonary Exacerbations

scholarly journals Role of C-reactive protein as a biomarker for prediction of the severity of pulmonary exacerbations in patients with cystic fibrosis

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Rosa Maria Girón-Moreno ◽  
José L Justicia ◽  
Sara Yamamoto ◽  
Claudia Valenzuela ◽  
Carolina Cisneros ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Pulmonary Exacerbations

scholarly journals Effect of pulmonary exacerbations treated with oral antibiotics on clinical outcomes in cystic fibrosis

Thorax ◽  
2016 ◽  
Vol 72 (4) ◽  
pp. 327-332 ◽  
Author(s):  
Sanja Stanojevic ◽  
Alexandra McDonald ◽  
Valerie Waters ◽  
Sarah MacDonald ◽  
Eric Horton ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Clinical Outcomes ◽  
Oral Antibiotics ◽  
Pulmonary Exacerbations

Approach to treating cystic fibrosis pulmonary exacerbations varies widely across us CF care centers

2011 ◽  
Vol 46 (9) ◽  
pp. 870-881 ◽  
Author(s):  
Nathan C. Kraynack ◽  
M. David Gothard ◽  
Lynn M. Falletta ◽  
John T. McBride
Keyword(s):  
Cystic Fibrosis ◽  
Pulmonary Exacerbations

scholarly journals Inflammation and Airway Microbiota during Cystic Fibrosis Pulmonary Exacerbations

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62917 ◽  
Author(s):  
Edith T. Zemanick ◽  
J. Kirk Harris ◽  
Brandie D. Wagner ◽  
Charles E. Robertson ◽  
Scott D. Sagel ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pulmonary Exacerbations

Sex differences in treatment patterns in cystic fibrosis pulmonary exacerbations

2021 ◽  
Author(s):  
Kristina Montemayor ◽  
Kevin J. Psoter ◽  
Noah Lechtzin ◽  
Sara W. Carson ◽  
Christian A. Merlo ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Sex Differences ◽  
Treatment Patterns ◽  
Pulmonary Exacerbations

scholarly journals Influenza-Associated Cystic Fibrosis Pulmonary Exacerbations

CHEST Journal ◽  
2010 ◽  
Vol 137 (4) ◽  
pp. 852-860 ◽  
Author(s):  
Justin R. Ortiz ◽  
Kathleen M. Neuzil ◽  
John C. Victor ◽  
Anna Wald ◽  
Moira L. Aitken ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pulmonary Exacerbations
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