scholarly journals Synthesis and Biological Evaluation of Novel Schiff Bases of Aryloxy Moiety

2019 ◽  
Vol 9 (5-s) ◽  
pp. 44-49
Author(s):  
Purushottam R. Laddha ◽  
Kailash R. Biyani
Keyword(s):  
Acetic Acid ◽  
Antifungal Activity ◽  
Schiff Bases ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Spectral Studies ◽  
Primary Amines ◽  
Antibacterial And Antifungal Activity ◽  
Phenoxy Acetic Acid ◽  
Antibacterial And Antifungal

Schiff's bases are condensation products of primary amines with carbonyl compounds. Schiff bases (imines) possess wide variety of biological activities that include antibacterial and antifungal activity. In present work, Schiff bases from 3,5- Dimethoxyphenol (aryloxy moiety) as starting material synthesized. Esterification of 3,5- Dimethoxyphenol led to formation of (3,5-Dimethoxy-phenoxy)-acetic acid ethyl ester (1). (3,5-Dimethoxy-phenoxy)-acetic acid hydrazide (2) is derived from Compound (1) by hydrazination. Compound (2) was reacted with different aromatic aldehydes to yield novel imines or Schiff bases (3A-I). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities. All the synthesized compounds had shown antibacterial and antifungal activity. Schiff bases 3C, 3D, 3E and 3I had shown good antimicrobial activity among all newly synthesized compounds. Keywords: Schiff base, aryloxy moiety, imines

Synthesis and Antimicrobial Evaluation of Some New 2-(6-Oxo-5,6- dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylacetamides

2010 ◽  
Vol 65 (5) ◽  
pp. 617-624 ◽  
Author(s):  
Prajwal L. Lobo ◽  
Boja Poojary ◽  
Kumsi Manjunatha ◽  
Nalilu Suchetha Kumari
Keyword(s):  
Acetic Acid ◽  
Antifungal Activity ◽  
Spectral Data ◽  
Good Yield ◽  
Antibacterial And Antifungal Activity ◽  
Acid Media ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

A series of 2-(6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylacetamides 6 were synthesized in good yield by condensing 5-aryloxymethyl-4H-1,2,4-triazole- 3-thiol 5 with various substituted N-phenyl-maleimides in acetic acid media. The newly synthesized compounds were characterized by spectral data and tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

scholarly journals Studies on NovelN4-[4,6-Diaryl-2-pyrimidinyl]-7-chloro-4-quinolinamine and their Microbicidal Efficacy

2009 ◽  
Vol 6 (s1) ◽  
pp. S406-S412 ◽  
Author(s):  
Arvind G. Mehta ◽  
Avnish A. Patel
Keyword(s):  
Antifungal Activity ◽  
Elemental Analysis ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activity ◽  
Guanidine Nitrate ◽  
Aryl Aldehyde ◽  
Antibacterial And Antifungal

The required chalcones1a-hwere prepared by reaction of substituted acetophenone with different aryl aldehyde, which in turn treated with guanidine nitrate, yielded 4-(substituted phenyl)-6-(substituted phenyl)-2-pyrimidinamine2a-h. Novel pyrimidine quinoline clubbed molecules3a-hhave been prepared by reaction of2a-hwith 4,7-dichloroquinoline. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

scholarly journals Chemistry and Biological Evaluation of Some New Triazolopyrimidine Derivatives Containing Isopropyl Group

2019 ◽  
pp. 390-396
Author(s):  
Janaki H. Chauhan ◽  
Haresh K. Ram
Keyword(s):  
Antifungal Activity ◽  
1H Nmr ◽  
Biological Evaluation ◽  
Spectroscopic Techniques ◽  
Efficient Synthesis ◽  
Antibacterial And Antifungal Activity ◽  
Isopropyl Group ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

An efficient Synthesis of a novel series of N,7-bis(substitutedphenyl)-4,7-dihydro-5-isopropyl-[1,2,4]triazolo-[1,5-a]pyrimidine-6-carboxamide (4a-j) was accomplished from N-(substituedphenyl)-4-methyl-3-oxopentanamide, 3-amino-1,2,4-triazole and different aldehyde reflex 20 min with DMF and then after the cooling product was obtained. All the recently synthesized compounds were characterized by the Mass, IR, 1H-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were assessed for their antibacterial and antifungal activity.

scholarly journals Synthesis , spectroscopic characterization and biological study of some new Schiff bases based on 2-hydroxybenzadehyde

2017 ◽  
Vol 13 (2) ◽  
pp. 5995-6005
Author(s):  
S. Abdelnabi ◽  
Chasib K. Bkhakh ◽  
Mouayed Y. Kadhum
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Schiff Bases ◽  
Aromatic Amines ◽  
Spectroscopic Characterization ◽  
Biological Study ◽  
Antibacterial And Antifungal Activity ◽  
Element Analysis ◽  
Antibacterial And Antifungal

Four new Schiff bases were synthesized from condensation of aldehyde ( 2-hydroxy benzaldehyde ) with aromatic amines (4-introaniline ; 4,4-oxydianiline ; 4,4-diaminodipleny sulfone and sulfanilamide) . These Schiff bases were characterized by IR, NMR , GC. mass and element analysis. Moreover, the Schiff bases were screened for their antibacterial and antifungal activity against various microorganisms and compared with standard compounds. In general , the results were indicated that some Schiff bases had good antimicrobial activity.

scholarly journals Synthesis and Studies of Novel Optically Active Schiff’s Base Derivatives and their Antimicrobial Activities

2010 ◽  
Vol 7 (2) ◽  
pp. 617-623 ◽  
Author(s):  
Ishwar J. Patel ◽  
Shailesh J. Parmar
Keyword(s):  
Antifungal Activity ◽  
Elemental Analysis ◽  
Acid Catalyst ◽  
Antimicrobial Activities ◽  
Optically Active ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activity ◽  
Schiff’S Base ◽  
Antibacterial And Antifungal

Several new Schiff’s base derivatives were prepared by condensing various substituted benzaldehyde with 1-(4-aminophenyl)-2-{4-[(S)-(4-chlorophenyl)(phenyl) methyl]-1-piperazinyl}ethanone in presence of acid catalyst under reflux condition. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.

Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff’s Bases of Sulphonamides

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Neeraj Kumar ◽  
Dhruti Bhatt ◽  
Chandra Shekhar Sharma ◽  
Hamendra Pratap Singh ◽  
Harshda Pandiya ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Biological Evaluation ◽  
Antibacterial And Antifungal Activity ◽  
Schiff’S Bases ◽  
E Coli ◽  
Schiff's Bases ◽  
Microbial Strains ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation

A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalcone derivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested for antibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A. clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significant antibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.

scholarly journals Synthesis, Characterization and Preliminary Biological Evaluation of New 3 and 4-nitro Isoindoline-1, 3-dione/phthalimide Analogues

2021 ◽  
pp. 20-27
Author(s):  
Sharad Sankhe ◽  
Nitesh Chindarkar
Keyword(s):  
Antifungal Activity ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
Bacterial Strains ◽  
In Vitro Antibacterial Activity ◽  
Nmr Techniques ◽  
Antibacterial And Antifungal

Aims: To synthesize new nitroisoindoline-1,3-diones analogues and evaluate their preliminary biological activities Methodology: New isoindoline-1,3-diones analogues were synthesized by coupling phthalic anhydride derivatives with appropriate aromatic amines. Newly synthesized heterocyclic compounds were evaluated for their in vitro antibacterial activity against gram-positive bacterial strains and gram-negative bacterial strains. They were also tested for their in vitro antifungal activity against fungi strains. Determination of the preliminary antibacterial and antifungal activity were investigated using agar-dilution method. The structures of newly synthesized analogues were elucidated by 1H and 13C-NMR techniques. Results: Bioassay indicated that some of the newly synthesized isoindoline-1,3-dione analogues shows moderate biological activities. Conclusion: Newly synthesized analogues can be used as antibacterial or antifungal agents on modifications.

scholarly journals Synthesis, characterization and biological evaluation of some newer carbazole derivatives

2014 ◽  
Vol 79 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Divyanshu Sharma ◽  
Nitin Kumar ◽  
Devender Pathak
Keyword(s):  
Cancer Cell Line ◽  
Aromatic Aldehydes ◽  
Biological Evaluation ◽  
Human Breast Cancer Cell ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activity ◽  
Human Breast ◽  
Anticancer Activities ◽  
Ft Ir ◽  
Antibacterial And Antifungal

A series of novel 5-((9H-carbazol-9-yl)methyl)-N-((substituted phenyl)(piperazin-1-yl)methyl)-1,3,4-oxadiazol-2-amine (4a-4o) derivatives was synthesized by starting with carbazole which on reaction with ethyl choloroacetate yielded ethyl 2-(9H-carbazole-9-yl)acetate (1), compound (1) on reaction with semicarbazide followed by cyclisation with sulphuric acid gave 5-((9H-carbazole-9-yl)-1,3,4-oxadiazol-2-amine (3) which through Mannich reaction with piperazine and a variety of aromatic aldehydes in the presence of acetic acid yielded the titled compounds (4a-4o). The structures of compounds were characterized by UV, FT-IR, 1H-NMR, MS spectral studies and elemental analysis. All the derivatives were evaluated for their antibacterial, antifungal and anticancer activities. Among the tested compounds 4a, 4d, 4e and 4n exhibited significant antibacterial and antifungal activity while the compounds 4a, 4d, 4k and 4n were found to be active on Human Breast Cancer Cell Line i.e. MCF7.

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