scholarly journals COMPARISON OF LEVELS OF TWENTY CHEMICAL ELEMENTS IN NORMAL THYROID TISSUE AND HYPERTROPHIC THYROID TISSUE

Author(s):  
Vladimir Zaichick

Background: Goiter can appear as a palpable or visible enlargement of the thyroid gland at the base of the neck. If the goiter is accompanied by hypothyroidism or hyperthyroidism, it may be accompanied by symptoms of the underlying disorder, and nodular goiter (NG) is a health problem of international importance. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of twenty chemical elements (ChE) Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn , Na, P, S, Si, Sr, V, and Zn are present in the goitrous transformed thyroid. Methods: Thyroid tissue level of twenty ChE was prospectively evaluated in 46 patients with NG and 105 healthy populations. The measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma atomic emission spectrometry, respectively.  Tissue samples were divided into two parts. One was used for morphological study while the other was for ChE analysis. Results: It was found that contents of Al, B, Br, Cl, Cu, Fe, Li, Mg, Mn, Na, P, S, Si, V, and Zn are significantly higher while the I levels are lower in NG than in normal tissues. Conclusion: There are considerable changes in ChE contents in goitrous tissue of thyroid. Thus, it is reasonable to assume that the levels of these ChE in thyroid tissue can be used as NG markers. However, this topic needs additional studies.                      Peer Review History: Received: 19 July 2021; Revised: 11 August; Accepted: 4 September, Available online: 15 September 2021 Academic Editor:  Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, [email protected] Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, [email protected]   Similar Articles: VITAMIN A, RETINOIC ACID AND TAMIBAROTENE, A FRONT TOWARD ITS ADVANCES: A REVIEW

2021 ◽  
Vol 11 (3) ◽  
pp. 242-257
Author(s):  
Vladimir Zaichick

Thyroid adenomas (TA) are benign tumors, but there is a 20% possibility of malignant transformation. The distinguishing between the TA and thyroid cancer (TC) is tricky, therefore new TA biomarkers are needed. Furthermore, the role of chemical elements (ChE) in etiology and pathogenesis of TA is unclear. The aim of this exploratory study was to evaluate whether significant changes in the thyroid tissue levels of twenty chemical elements (ChE) Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn, Na, P, S, Si, Sr, V, and Zn exist in the adenomatous transformed thyroid. Thyroid tissue levels of twenty ChE were prospectively evaluated in 19 patients with TA and 105 healthy inhabitants. Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma atomic emission spectrometry, respectively. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for ChE analysis. It was found that contents of of Al, B, Br, Cl, Cu, Na, and Zn are significantly higher whereas the levels of I some lower. in TA than in normal tissues. It was supposed that the changes in levels Al, B, Br, Cl, Cu, I, Na, and Zn in thyroid tissue can be used as TA markers.


2021 ◽  
Vol 36 ◽  
pp. 06031
Author(s):  
Olga Zaiko ◽  
Andrey Nazarenko ◽  
Marya Strizhkova ◽  
Aleksandr Zheltikov ◽  
Tatyana Konovalova

The presented results expand the understanding of the normal chemical composition of the body. The study was carried out on the basis of a pig-breeding farm in the Altai Territory in 2016-2020 on clinically healthy 6-month-old pigs of the Landrace breed. Chemical analysis of pig bristles was performed by inductively coupled plasma atomic emission spectrometry. The data were processed using Statistica 8 software (StatSoft Inc., USA). A study of the correlations between phosphorus in bristles and other macro-, microelements, as well as chemical elements associated with phosphorus, has been carried out. Only positive connections of different strengths have been established between phosphorus and elements involved in the formation of bone tissue (calcium, magnesium, manganese), copper, iron and strontium. There are two groups of direct interactions of different strengths between the chemical elements associated with phosphorus. Explained supposedly the essence of the connections, which is consistent in the bristle, as the final site of exchange, with organs and tissues of mammals.


1995 ◽  
Vol 36 (4-6) ◽  
pp. 338-345 ◽  
Author(s):  
Stefan Nilsson ◽  
Mats Wikström ◽  
Hans J. Martinussen ◽  
Anders Ericsson ◽  
Gerhard Wikström ◽  
...  

The aim of this study was to investigate whether dysprosium (Dy) induced signal intensity (SI) loss in infarcted tissue in MR imaging. Myocardial infarction was induced in 12 pigs and Dy-DTPA-BMA (1.0 mmol/kg b.w.) was administered i.v. to 6 pigs 4 hours after occlusion and allowed to accumulate in the infarctions for 2 hours. Dy was analysed by inductively coupled plasma atomic emission spectrometry in infarcted and non-ischaemic tissue samples. The remaining 6 pigs, not administered contrast medium, served as controls. The infarctions demonstrated a high SI in the proton density- and T2-weighted sequences in both groups ( ex vivo), although the Dy-DTPA-BMA group demonstrated a 3-fold greater concentration of Dy in infarcted compared with non-ischaemic myocardium. The lack of SI loss after Dy accumulation indicates that susceptibility effects are minor or absent in infarcted myocardium.


Author(s):  
Vladimir Zaichick

Background: Thyroid benign nodules (TBNs) are the most common diseases of this endocrine gland and are common worldwide. Among TBNs the colloid goiter (CG) and thyroid adenoma (TA) are very frequentdiseases. Evaluation of variant of TBNs is clinically important for subsequent therapeutic interventions, as well as for a clearer understanding the etiology of these disorders. The aim of this exploratory study was to examine differences in the content offifty trace elements (TE) in CG and TA tissues. Methods: Thyroid tissue levels of TE have prospectively evaluated in 46 patients with CG and 19 patients with TA. Measurements have performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides (INAA-LLR) and inductively coupled plasma mass spectrometry (ICPMS), respectively. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for TE analysis. Results: It was observed that in both CG and TA tissues the contents of Ag, Al, Cr, Hg, Mn, Th, and Zn increased, whereas the levels of Au, Be, Cs, Pb, Rb, Sb, Sc, Th, Yb, and Zr were unchanged in comparison with normal thyroid tissue. No differences were found between the TE contents of CG and TA. Conclusions: From results obtained, it was possible to conclude that the common characteristics of CG and TA tissue samples were of a high level of Ag, Al, Cr, Hg, Mn, Th, and Zn in comparison with normal thyroid and, therefore, these TE could be involved in etiology and pathogenesis of thyroid disorders such as CG and TA.                    Peer Review History: Received: 12 November 2021; Revised: 15 December; Accepted: 31 December, Available online: 15 January 2022 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia,  Indonesia, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, [email protected] Rima Benatoui, Laboratory of Applied Neuroendocrinology, Department of Biology, Faculty of Science, Badji Mokhtar University Annaba, BP12 E L Hadjar–Algeria, [email protected] Similar Articles: COMPARISON OF LEVELS OF TWENTY CHEMICAL ELEMENTS IN NORMAL THYROID TISSUE AND HYPERTROPHIC THYROID TISSUE


2020 ◽  
Vol 86 (5) ◽  
pp. 16-21
Author(s):  
T. A. Karimova ◽  
G. L. Buchbinder ◽  
S. V. Kachin

Calibration by the concentration ratio provides better metrological characteristics compared to other calibration modes when using the inductively coupled plasma atomic emission spectrometry (ICP-AES) for analysis of geological samples and technical materials on their base. The main reasons for the observed improvement are: i) elimination of the calibration error of measuring vessels and the error of weighing samples of the analyzed materials from the total error of the analysis; ii) high intensity of the lines of base element; and iii) higher accuracy of measuring the ratio of intensities compared to that of measuring the absolute intensities. Calcium oxide is better suited as a base when using calibration by the concentration ratio in analysis of carbonate rocks, technical materials, slags containing less than 20% SiO2 and more than 20% CaO. An equation is derived to calculate the content of components determined in carbonate materials when using calibration by the concentration ratio. A method of ICP-AES with calibration by the concentration ratio is developed for determination of CaO (in the range of contents 20 – 100%), SiO2 (2.0 – 35%), Al2O3 (0.1 – 30%), MgO (0.1 – 20%), Fe2O3 (0.5 – 40%), Na2O (0.1 – 15%), K2O (0.1 – 5%), P2O5 (0.001 – 2%), MnO (0.01 – 2%), TiO2 (0.01 – 2.0%) in various carbonate materials. Acid decomposition of the samples in closed vessels heated in a HotBlock 200 system is proposed. Correctness of the procedure is confirmed in analysis of standard samples of rocks. The developed procedure was used during the interlaboratory analysis of the standard sample of slag SH17 produced by ZAO ISO (Yekaterinburg, Russia).


Sign in / Sign up

Export Citation Format

Share Document