Objectives: The objective is to compare the radiological outcome of closedinterlock intramedullary nailing versus dynamic compression plating in closed tibial fracture.Study Design: Randomized controlled trials. Setting: Department of orthopedics NishtarHospital Multan. Period: 9th July 2016 to March 2017. Methodology: There were 302 patientsdivided in two equal groups of 151. Permission was taken from the ethical committee of NishtarHospital. The 302 patients in age group 20-50 years of both genders meeting the inclusionand exclusion criteria attending the outpatient clinic or admitted to the orthopedics departmentthrough emergency were included in the study. All the data entered and analyzed usingcomputer software SPSS version 10. For quantitative variables like age and duration of fracturemean and standard deviation was calculated. For categorical variables like gender, malunionand infection frequency and percentage were calculated. Chi-square test was applied tocompare the malunion and infection in both groups. A p value 0.05 was considered statisticallysignificant. Results: The 100% (n=302) patients were divided into 2 groups equally, 151 ineach, i.e. intramedullary nail (group 1) and dynamic compression plating (group 2). The mainoutcome variables of this study were the malunion and infection. It was observed that malunionpresented as 57% (n=86) and 70.9% (n=107) in group 1 and group 2 respectively. It was alsoobserved that infection presented as 23.2% (n=35) and 37.1% (n=56) in group 1 and group 2respectively. After applying chi-square test, it was noted that malunion associated with groupshaving p-value 0.012. But it was not associated with gender, stratified age and duration offracture having p-values 0.497, 0.800 and 0.218 respectively. Similarly, after applying chi-squaretest, it was noted that infection associated with gender and groups having p-values 0.007 and0.008 respectively. But it was not associated with stratified age and duration of fracture havingp-values 0.565 and 0.344 respectively. Conclusion: Closed interlock intramedullary nailinghas malunion and infection rates less than dynamic compression plating. So closed interlockintramedullary nailing is preferred method of closed tibia diaphyseal fracture treatment.