scholarly journals Сatamnestic data on the effect of interferon therapy on the course of combined HIV/HCV-infection

2021 ◽  
Vol 13 (1) ◽  
pp. 45-52
Author(s):  
V. Kh. Fazylov ◽  
E. R. Manapova ◽  
V. O. Akifev

Aim: catamnestic analysis of the effectiveness of antiviral therapy for chronic hepatitis C in combination with HIV infection.Materials and methods. A retrospective study included 145 patients with combined HCV/HIV infection for 8±0,43 years.Results. 55% of patients received antiviral therapy for chronic hepatitis with pegylated interferons and ribavirin. The frequency of achieving a stable virological response is 73%. Persistent virological response with favorable Il-28B genotypes was detected in 85% of cases, with unfavorable genotypes less frequently — in 63% (p=0,028); the relapse rate is 27%. The level of HIV RNA viral load and the frequency of patients with secondary diseases was higher in patients with natural HCV/HIV infection with favorable interleukin-28B genotypes compared to other comparison groups (р<0,05).Conclusion. The course of chronic hepatitis C after therapy was more positive with favorable Il-28B genotypes. HIV infection was more severe in the absence of antiviral therapy for chronic hepatitis C.

2013 ◽  
Vol 58 (2) ◽  
pp. 391-395 ◽  
Author(s):  
Pablo Barreiro ◽  
Pablo Labarga ◽  
José V. Fernández-Montero ◽  
Eva Poveda ◽  
Carmen de Mendoza ◽  
...  

2003 ◽  
Vol 38 ◽  
pp. 180
Author(s):  
J.M. Vrolijk ◽  
H.L.A. Janssen ◽  
J. Kwekkeboom ◽  
B.E. Hansen ◽  
P. Zondervan ◽  
...  

2015 ◽  
Vol 20 (2) ◽  
pp. 25-29
Author(s):  
A. M Ryumin ◽  
O. V Korochkina ◽  
D. M Sobchak ◽  
O. L Sobolevskaya ◽  
T. Yu Butina ◽  
...  

Despite numerous investigations, the problem ofpredicting of efficiency of the antiviral therapy of chronic hepatitis C (CHC) remains to be actual. As recent investigations showed polymorphism of IL-B28 gene in large part determines the achievement of the sustained virological response. In this study in 70 CHC patients there were evaluated factors which influence on the results of the treatment, their occurrence in the population, and the use the control them as a predictor of the efficacy of the therapy. There is considered the possibility of correction of some of them. This allows you to predict the achievement of sustained virological response. There has been confirmed the need for the accounting of IL-B28 gene polymorphism in the relation to the wide spread occurence in the population of normal genotypes in loci Rs12979860 and Rs8099917.


Chemotherapy ◽  
2007 ◽  
Vol 53 (4) ◽  
pp. 292-299 ◽  
Author(s):  
Arne Schäfer ◽  
Michael Scheurlen ◽  
Benedikt Weissbrich ◽  
Katrin Schöttker ◽  
Michael R. Kraus

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