scholarly journals Quinazoline and its diverse array of therapeutic application:A review

2021 ◽  
Vol 05 (02) ◽  
Author(s):  
Anagha S Upasani
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Heterocyclic Chemistry ◽  
Detailed Survey ◽  
Naturally Occurring ◽  
Active Moiety ◽  
Structure Activity ◽  
Ring Structures ◽  
Important Branch

Heterocyclic chemistry being an important branch of chemistry includes many ring structures with heteroatoms such as nitrogen, oxygen, and sulfur. Quinazoline is an important nitrogen containing benzofused heterocycle and has several therapeutic actions such as antimalarial, antimicrobial, anticancer, and anticonvulsant. Quinazoline was first isolated from alkaloid vasicine. Vasicine, deoxyvasicine, tryptanthrin, and rutecarpine are some of the potent naturally occurring quinazolines. Substitutions on different positions of quinazoline ring lead to different activities. Detailed survey of activities of quinazoline such as anticancer, anticonvulsant, antifungal, antibacterial, and antidiabetic according to structure–activity relationship and marketed preparations containing quinazoline as an active moiety is described in this review.

Bioactivities of Natural Catalpol Derivatives

2019 ◽  
Vol 26 (33) ◽  
pp. 6149-6173 ◽  
Author(s):  
Liu-Qiang Zhang ◽  
Kai-Xian Chen ◽  
Yi-Ming Li
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Inhibitory Potency ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Extensive Coverage ◽  
Relationship Of

Catalpol, a famous molecule of iridoids, possesses extensive pharmacological activities. Our studies found that compounds with low-polarity substituents at the 6-O position of catalpol exhibited higher NF-κB inhibitory potency than catalpol. However, catalpol derivatives are not much focused. Here this review provides extensive coverage of naturally occurring catalpol derivatives discovered from 1888 until 2018. It covers their distribution, chemotaxonomic significance, chemical structures, and bioactivities from more than 200 peer-reviewed articles, and highlights the structure-activity relationship of catalpol derivatives.

scholarly journals Structure-activity relationship study for fungicidal activity of 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4-triazole derivatives against rice blast

2015 ◽  
Vol 55 (4) ◽  
pp. 383-388 ◽  
Author(s):  
Tomoki Hoshi ◽  
Kazuhiro Yamada ◽  
Yuko Yoshizawa ◽  
Keimei Oh
Keyword(s):  
Antifungal Activity ◽  
Rice Blast ◽  
Fungicidal Activity ◽  
Antifungal Agents ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Triazole Derivatives ◽  
Structure Activity ◽  
Ring Structures

Abstract To explore new antifungal agents for rice blast control, the antifungal activity of a series of novel 1,2,4-triazole derivatives against Magnaporthe oryzae has been evaluated. The antifungal activity was determined by using in vitro mycelial growth inhibition tests. Among the 19 test compounds, we found that the compound 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4- triazole (Gj) displayed potent antifungal activity against M. oryzae. The IC50 value was found approximately 3.8±0.5 μM and the IC50 value of propiconazole was found to be approximately 3.7±0.2 μM, respectively. Structure-activity relationship studies on aromatic ring structures provided insight and information about the structural requirements for antifungal activity of this synthetic series against M. oryzae.

(7S)-Kaitocephalin as a potent NMDA receptor selective ligand

2016 ◽  
Vol 14 (4) ◽  
pp. 1206-1210 ◽  
Author(s):  
Yoko Yasuno ◽  
Makoto Hamada ◽  
Masanori Kawasaki ◽  
Keiko Shimamoto ◽  
Yasushi Shigeri ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligand ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Selective Ligand ◽  
Sar Study

A structure–activity relationship (SAR) study of kaitocephalin, known to be a potent naturally occurring NMDA receptor ligand, was performed.

Natural Flavans and (Iso)Flavanones with anticancer activity: A Review

2021 ◽  
Vol 25 ◽  
Author(s):  
Arindam Gangopadhyay
Keyword(s):  
Cytotoxic Activity ◽  
Anticancer Activity ◽  
Structure Activity Relationship ◽  
Present Review ◽  
Activity Relationship ◽  
Cytotoxic Potential ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Source Structure

: The present review describes 108 new examples of naturally occurring flavans and flavanones having cytotoxic potential reported during the period of 2005 to Mid-2020. These compounds are found either as aglycones or as glycosides, comprising flavans, flavanones, isoflavanones and miscellaneous flavanones (homo- and bi-flavanones). The main topics addressed are source, structure, cytotoxic activity in details and structure-activity relationship. The review cites 114 references.

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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