scholarly journals Verrucous mass of the leg in an octogerian woman

2021 ◽  
Author(s):  
Mariem Rekik ◽  
Khadija Sellami ◽  
mariem Amouri ◽  
Saadia Makni ◽  
Naourez Gouiaa ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Atypical Presentation ◽  
Endemic Country ◽  
Clinical Forms

Various clinical forms of cutaneous leishmaniasis can be encountered such as: ulcerated, lupoïd, sporotrichoïd and other rare forms (eczematiform, erysipeloid, psoriasiform, verrucous, and pseudotumoral). We report an atypical presentation. Dermatologists should be aware when facing a verrucous mass, especially if the patient comes from an endemic country.

Morita-Baylis-Hillman adduct shows in vitro activity against Leishmania (Viannia) braziliensis associated with a reduction in IL-6 and IL-10 but independent of nitric oxide

Parasitology ◽  
2012 ◽  
Vol 140 (1) ◽  
pp. 29-38 ◽  
Author(s):  
F. M. AMORIM ◽  
Y. K. S. RODRIGUES ◽  
T. P. BARBOSA ◽  
P. L. N. NÉRIS ◽  
J. P. A. CALDAS ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cutaneous Leishmaniasis ◽  
Clinical Manifestations ◽  
Failure Rates ◽  
In Vitro Activity ◽  
Clinical Forms ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis ◽  
Human Infections

SUMMARYCurrent treatments for different clinical forms of leishmaniasis are unsatisfactory, highly toxic and associated with increasing failure rates resulting from the emergence of resistant parasites. Leishmania (Viannia) braziliensis is the main aetiological agent of different clinical forms of American tegumentary leishmaniasis, including the mucosal form for which treatment has high failure rates. The aim of this work was to investigate the activity of the Morita-Baylis-Hillman adduct, methyl 2-{2-[hydroxy(2-nitrophenyl)methyl])acryloyloxy} benzoate in vitro against isolates of L. (V.) braziliensis obtained from patients with different clinical manifestations of tegumentary leishmaniasis: localized cutaneous leishmaniasis, mucosal leishmaniasis and disseminated cutaneous leishmaniasis. The adduct effectively inhibited the growth of promastigotes of the different isolates of L. (V.) braziliensis (IC50 ⩽ 7·77 μg/ml), as well as reduced the infection rate of macrophages infected with these parasites (EC50 ⩽ 1·37 μg/ml). It is remarkable to state that the adduct was more effective against intracellular amastigotes (P ⩽ 0·0045). The anti-amastigote activity correlated with an immunomodulatory effect, since the adduct was able to decrease the production of IL-6 and IL-10 by the infected macrophages. However, its effect was independent of nitric oxide production. This work demonstrates the anti-leishmanial activity of methyl 2-{2-[hydroxy(2-nitrophenyl)methyl])acryloyloxy} benzoate and suggests its potential in the treatment of human infections caused by L. (V.) braziliensis.

scholarly journals Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole

2013 ◽  
Vol 33 (2) ◽  
pp. 187-191 ◽  
Author(s):  
Soumaya Yaich ◽  
Khaled Charfeddine ◽  
Abderrahmen Masmoudi ◽  
Mondher Masmoudi ◽  
Sawssen Zaghdhane ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Cutaneous Leishmaniasis ◽  
Renal Transplant Recipient ◽  
Atypical Presentation

scholarly journals Mucocutaneous Leishmaniasis/HIV Coinfection Presented as a Diffuse Desquamative Rash

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Guilherme Almeida Rosa da Silva ◽  
Daniel Sugui ◽  
Rafael Fernandes Nunes ◽  
Karime de Azevedo ◽  
Marcelo de Azevedo ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Wide Spectrum ◽  
Atypical Presentation ◽  
Risk Of Infection ◽  
Mucocutaneous Leishmaniasis ◽  
Hiv Coinfection ◽  
Clinical Syndromes ◽  
Tropical Areas ◽  
Granular Base ◽  
Animal Reservoirs

Leishmaniasis is an infectious disease that is endemic in tropical areas and in the Mediterranean. This condition spreads to 98 countries in four continents, surpassing 12 million infected individuals, with 350 million people at risk of infection. This disease is characterized by a wide spectrum of clinical syndromes, caused by protozoa of the genusLeishmania, with various animal reservoirs, such as rodents, dogs, wolves, foxes, and even humans. Transmission occurs through a vector, a sandfly of the genusLutzomyia. There are three main clinical forms of leishmaniasis: visceral leishmaniasis, cutaneous leishmaniasis, and mucocutaneous leishmaniasis. The wide spectrum of nonvisceral forms includes: localized cutaneous leishmaniasis, a papular lesion that progresses to ulceration with granular base and a large framed board; diffuse cutaneous leishmaniasis; mucocutaneous leishmaniasis, which can cause disfiguring and mutilating injuries of the nasal cavity, pharynx, and larynx. Leishmaniasis/HIV coinfection is considered an emerging problem in several countries, including Brazil, where, despite the growing number of cases, a problem of late diagnosis occurs. Clinically, the cases of leishmaniasis associated with HIV infection may demonstrate unusual aspects, such as extensive and destructive lesions. This study aims to report a case of mucocutaneous leishmaniasis/HIV coinfection with atypical presentation of diffuse desquamative eruption and nasopharyngeal involvement.

scholarly journals A successful treatment of severe lupoid cutaneous leishmaniasis in an elderly man: a case report

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Sulafa Ahmad ◽  
Hamid Suleiman ◽  
Zuheir Al-Shehabi
Keyword(s):  
Elderly Patient ◽  
Case Report ◽  
Cutaneous Leishmaniasis ◽  
Inflammatory Infiltrate ◽  
Clinical Presentation ◽  
Atypical Presentation ◽  
Histopathologic Examination ◽  
Dermatology Department ◽  
Adequate Treatment ◽  
History Of

ABSTRACT Lupoid cutaneous leishmaniasis (LCL) is a rare, atypical presentation of cutaneous leishmaniasis (CL). In this report, the authors present the case of a severe LCL in an elderly patient who presented to our dermatology department with severe, painful ulcerated lesion on his midface with cosmetic deformity to his nose. He had a history of CL 3 years ago at the same place. Histopathologic examination showed epidermal and dermal changes with chronic inflammatory infiltrate and no leishmaniasis bodies were detected. He was admitted and treated with systemic glucantime (60 mg/kg) for a month followed by hydroxychloroquine (200 mg twice a day) for another month with favorable outcome. Countries with endemic CL should consider LCL in patients with a history of leishmaniasis and a similar clinical presentation, especially that it could be misdiagnosed with other granulomatous cutaneous conditions, thus leading to cosmetic deformities that can be avoided with early adequate treatment.

scholarly journals Auricular enlargement: An atypical presentation of old world cutaneous leishmaniasis

2011 ◽  
Vol 56 (4) ◽  
pp. 428 ◽  
Author(s):  
RezaMahmoud Robati ◽  
Mehdi Qeisari ◽  
Mona Karimi ◽  
Marjan Saeedi
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Atypical Presentation ◽  
Old World

scholarly journals Leishmania spp. seropositivity in Austrian soldiers returning from the Kosovo

2020 ◽  
Vol 132 (1-2) ◽  
pp. 47-49 ◽  
Author(s):  
Edwin Kniha ◽  
Julia Walochnik ◽  
Wolfgang Poeppl ◽  
Gerhard Mooseder ◽  
Adelheid G. Obwaller
Keyword(s):  
Visceral Leishmaniasis ◽  
Cutaneous Leishmaniasis ◽  
Risk Of Infection ◽  
Protective Measures ◽  
Vector Borne Disease ◽  
Clinical Forms ◽  
Mediterranean Countries ◽  
Leishmania Spp ◽  
Balkan Region ◽  
Vector Borne

SummaryLeishmaniasis is a severe vector-borne disease with two main clinical forms, visceral leishmaniasis and cutaneous leishmaniasis. Both forms of leishmaniasis are also endemic in Mediterranean countries including the Balkan region from where mainly visceral leishmaniasis is reported. Austrian soldiers returning from Kosovo were screened for anti-Leishmania antibodies to assess the risk of infection during operations. Anti-Leishmania antibodies were detected in more than 20% of the soldiers investigated, which indicates a considerable risk of infection during missions in this area and thus suggests the application of protective measures.

Genetic diversity of Leishmania major strains isolated from different clinical forms of cutaneous leishmaniasis in southern Iran based on minicircle kDNA

2013 ◽  
Vol 19 ◽  
pp. 226-231 ◽  
Author(s):  
Ahmad Oryan ◽  
Sadegh Shirian ◽  
Mohammad-Reza Tabandeh ◽  
Gholam-Reza Hatam ◽  
Gerrit Randau ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Southern Iran ◽  
Clinical Forms
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