scholarly journals Report of a recurrent tongue malignant melanoma and review of literature

2021 ◽  
Author(s):  
Maziar Motiee-Langroudi ◽  
Athena Farahzadi ◽  
Pouyan Aminishakib
Keyword(s):  
Malignant Melanoma ◽  
Rare Disease ◽  
Treatment Modality ◽  
Mucosal Melanoma ◽  
Optimal Treatment ◽  
Review Of Literature ◽  
Low Incidence ◽  
Oral Mucosal Melanoma ◽  
Late Recognition

Primary oral mucosal melanoma is a rare disease. Etiopathogenesis of oral mucosal melanoma (OMM) is inadequately understood. The prognosis of OMM is very poor . Due to its low incidence and late recognition, the optimal treatment modality is not well established. Surgery with free margins is the mainstay of treatment.

scholarly journals Surgical Decision Making in Oral Mucosal Melanoma with Lymphadenopathy: Review of Literature

2014 ◽  
Vol 5 (3) ◽  
pp. 135-139
Author(s):  
Srijon Mukherjee ◽  
Yogendra Singh Chauhan ◽  
Niladri Bakshi
Keyword(s):  
Decision Making ◽  
Mucosal Melanoma ◽  
Review Of Literature ◽  
Surgical Decision ◽  
Upper Cervical ◽  
Cervical Swelling ◽  
Improvement In Survival ◽  
Surgical Decision Making ◽  
Head Neck ◽  
Oral Mucosal Melanoma

ABSTRACT The oral mucosal melanoma (OMM) comprises less than 1% of all malignant melanomas. Most mucosal melanomas occur in occult site, which together with lack of early and specific signs contribute to late and poor diagnosis. Because of their rareness, the knowledge about their pathogenesis and risk factors is insufficient, and also there are not well-established protocols for staging and treatment of mucosal melanomas with lymphadenopathy. Surgery is the mainstay of treatment. Radiotherapy and other adjunctive therapies can provide better local control in some locations, but did not show improvement in survival. In this article, we present a case of 52-year-old female with OMM (excision performed elsewhere) presenting with large left upper cervical swelling after 2 years postexcision. We will review the literature that help us in taking decision in the management of OMMs in light of following patient. How to cite this article Bakshi N, Mukherjee S, Chauhan YS. Surgical Decision Making in Oral Mucosal Melanoma with Lymphadenopathy: Review of Literature. Int J Head Neck Surg 2014;5(3):135-139.

scholarly journals Treatment of recurrent mucosal melanoma of the oral cavity with topical imiquimod and pembrolizumab achieves complete histopathologic remission

2021 ◽  
Vol 9 (10) ◽  
pp. e001219
Author(s):  
Tejus Satish ◽  
Shaheer Khan ◽  
Matt Levin ◽  
Richard Carvajal ◽  
Angela J Yoon
Keyword(s):  
Malignant Melanoma ◽  
Hard Palate ◽  
Mucosal Melanoma ◽  
Topical Imiquimod ◽  
Melanoma In Situ ◽  
Oral Melanoma ◽  
Pigmented Lesions ◽  
Adjuvant Temozolomide ◽  
Oral Mucosal Melanoma

Mucosal melanomas constitute a subtype of melanoma with less effective treatments than cutaneous melanomas. We present a case of oral mucosal melanoma that recurred despite multiple resections and adjuvant temozolomide. Treatment with topical imiquimod combined with pembrolizumab achieved remission. A 56-year-old woman presented with a pigmented mass on her left anterior hard palate. Biopsy revealed malignant melanoma. The patient had resection with neck dissection with 3 months of adjuvant temozolomide due to positive margins. Malignant melanoma involving the hard palate recurred 1 year later requiring additional resection. Two years later, two additional pigmented lesions were found; further resections were deferred due to expected morbidity. Following 6 weeks of topical imiquimod treatment, the lesions shrunk significantly. Adjuvant pembrolizumab was added and complete histopathologic remission was observed in 6 months. The patient remained in remission for 4 years before new melanoma in situ was diagnosed, requiring five additional months of imiquimod. As of April 2021, there is no clinical evidence of melanoma. There are limited reports of oral melanoma treated with topical imiquimod. Here, imiquimod administered in combination with pembrolizumab achieved complete pathologic response.

Primary Oral Mucosal Melanoma: A Case Series

2021 ◽  
Author(s):  
Ankita Chugh ◽  
Yogesh Mittal ◽  
Shruti Khatana ◽  
Aditi Mishra ◽  
Shilajit Bhattacharya ◽  
...  
Keyword(s):  
Case Series ◽  
Mucosal Melanoma ◽  
Oral Mucosal Melanoma

scholarly journals Primary Malignant Melanoma of the Vagina without Metastasis: A Rare Case and Review of Literature

2020 ◽  
Author(s):  
Wilson Bizimana ◽  
Gloria Akimana ◽  
Arthur Semedo Insumbo ◽  
Hounayda Jerguigue ◽  
Rachida Latib ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Patient Survival ◽  
Rare Condition ◽  
Primary Malignant Melanoma ◽  
Imaging Features ◽  
Review Of Literature ◽  
Pelvic Magnetic Resonance Imaging ◽  
Improve Patient Survival ◽  
Appropriate Treatment ◽  
Improve Patient

AbstractMalignant melanoma of vagina is a rare condition. Its histogenesis has been debated and the positive diagnosis is based on immunohistochemistry. Pelvic magnetic resonance imaging remains the gold standard for assessing locoregional extension status and post-treatment surveillance of melanoma of vagina. The observation concerned a 53-year-old woman with no specific history who presented a primary malignant melanoma of vagina without secondary locations. To date, the case is the second one reported in the literature. Early diagnosis of the malignant melanoma of vagina may improve patient survival because late diagnoses are punctuated by poor prognosis. We have presented epidemiological with etiopathogenic characteristics and described all imaging features to stage the tumor and to conduct the appropriate treatment.

scholarly journals Sinonasal mucosal melanoma: treatment strategies and survival rates for a rare disease entity

2021 ◽  
Author(s):  
Alexandros Andrianakis ◽  
Peter Kiss ◽  
Markus Pomberger ◽  
Axel Wolf ◽  
Dietmar Thurnher ◽  
...  
Keyword(s):  
Rare Disease ◽  
Survival Data ◽  
Survival Rates ◽  
Delayed Diagnosis ◽  
Distant Metastases ◽  
Primary Treatment ◽  
Mucosal Melanoma ◽  
Disease Entity ◽  
Improve Outcome ◽  
Initial Symptoms

Summary Background Sinonasal mucosal melanoma (SNMM) is a rare disease entity comprising 0.4–1.3% of all melanomas. Surgery with free margins has been the primary treatment over decades. Neither the addition of radiotherapy nor chemotherapy could significantly improve outcome rates of this devastating malignancy. This study presents our clinical experience with SNMM over a 19-year period and summarizes the current body of literature on SNMM. Methods This retrospective analysis included 12 patients with SNMM treated from 2001 to 2019 at an academic center. Additionally, a literature review of the last 29 years on treatment and survival data of SNMM was conducted. Results Main initial symptoms were epistaxis and nasal obstruction. Of the patients 9 underwent endoscopic surgery, 6 received adjuvant therapy. 3 patients who did not undergo surgery, received chemoradiotherapy, radiotherapy alone, and chemotherapy alone, respectively. At the time of diagnosis 2 patients had distant metastases and 4 patients developed distant metastases during the course of the disease. Mean overall survival (OS) was 30.6 months, 3‑year and 5‑year OS were 25%, and 18.2%, respectively. Conclusion Unspecific symptoms and hidden anatomic locations lead to delayed diagnosis and increased rates of metastatic dissemination. Distant metastasis is the main treatment failure in SNMM. Surgery with free margins remains the primary treatment for SNMM. Adjuvant radiotherapy might improve local control in individual cases but efficient systemic therapy is needed to improve outcome rates. To evaluate and define more effective targeted treatment options and improve outcome rates, homogeneous data and prospective multicentric analysis are needed.

scholarly journals Oral mucosal melanoma

2017 ◽  
Vol 2 ◽  
pp. 2057178X1770581
Author(s):  
RAG Khammissa ◽  
M Altini ◽  
S Meer ◽  
J Lemmer ◽  
L Feller
Keyword(s):  
Mucosal Melanoma ◽  
Oral Mucosal Melanoma

scholarly journals Primary Oral Malignant Melanoma: Two Case Reports and Review of Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Neeraj Sharma
Keyword(s):  
Malignant Melanoma ◽  
Early Detection ◽  
Oral Cavity ◽  
Tumor Size ◽  
Malignant Tumors ◽  
Case Reports ◽  
Review Of Literature ◽  
Oral Region ◽  
Rare Neoplasm ◽  
Oral Malignant Melanoma

Primary malignant melanoma of the oral cavity is a rare neoplasm. The tumors tend to metastasize or locally invade tissue more readily than other malignant tumors in the oral region. The survival of patients with mucosal melanomas is less than for those with cutaneous melanomas. Tumor size and metastases are related to the prognosis of the disease. Early detection, therefore, is important.

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