scholarly journals Clinical outcomes after microfracture treatment of full-thikness articular cartilage lesions of the knee

2013 ◽  
Vol 60 (4) ◽  
pp. 54-57
Author(s):  
Konstantin Mitev ◽  
Igor Kaftangiev
Keyword(s):  
Articular Cartilage ◽  
Clinical Outcomes ◽  
Cartilage Lesion ◽  
Functional Results ◽  
Womac Score ◽  
Clinical Results ◽  
Short Term ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions

Purpose: The purpose of the study is to evaluate the clinical results after microfracture treatment of the full-thikness articular lesions of the knee. Methods: This study presented clinical outcomes of 51 patients with focal full thikness articular cartilage lesion who were treated with microfracture technique and evaluated according Lysholm-Tegner, Oxford, Womac and KSS scores. According the age we examined of patients younger than 35 years and second group between 36-60 years old. Results: On the basis of follow-up at minimum 18 months, mean improvements in Lysholm-Ttegner scores in younger group (from 38.4-94.1) in older group (from 37.1-87.3), Oxford scores in younger (from 29.5-45.2) and older group (from 25.5-50.5), and Womac score in younger group (from 51.1-94.8) in older (from 50.8-87.8). There was a strong and significant correlation between functional results and age of the patients with full-thikness cartilage lesion less than 2 cm in dijametar. Conclusions: According to our short term results, microfracture technique is effective treatment for the full-thikness cartilage lesions with regard to the improvements of daily activities with a favorable impact on pain relief and better functional results. There was a strong correlation between functional results and age, size of defect location of defect as prognostic parameters.

scholarly journals Comparison of short-time functional outcomes after TKA between Multigen Plus CR and Physica KR prostheses

2021 ◽  
Author(s):  
P. Lisý ◽  
J. Čabala ◽  
M. Hrubina ◽  
M. Melišík ◽  
L. Nečas
Keyword(s):  
Functional Outcomes ◽  
Primary Total Knee Arthroplasty ◽  
Functional Results ◽  
Womac Score ◽  
Clinical Results ◽  
Short Term ◽  
Significant Difference ◽  
Womac Questionnaire ◽  
Long Term Follow Up

Abstract Background Aim of this study was to compare functional results within 36 months following primary total knee arthroplasty (TKA) using a conventional prosthesis Multigen Plus CR and a new Physica KR implant. Our hypothesis was that the use of the Kinematics-Retaining design of an TKA implant leads to a significantly greater improvement in the active range of motion and better functional results (KSS 1, KSS 2 and WOMAC score) than the conventional CR implant at short-term follow-up. Materials and methods We retrospectively analysed data of 234 patients who underwent primary TKA at our hospital from April 2010 to August 2015 with the CR type of implant and from July 2014 to August 2015 with the KR implant due to advanced knee arthrosis of IIIrd and IVth grade of Kellgren-Lawrence classification, with no major ligamentous instability. Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, Knee Society Scores 1 (KSS 1) and 2 (KSS 2) and flexion (AROM) were recorded preoperatively and at 6, 12 and 36 months after surgery. Results Our study showed a statistically significant difference in functional results at three years with better KSS 1 score, a tendency to higher values in the KSS 2 score, as well as a statistically significant overall improvement in AROM in favour of the new KR design over the conventional CR implant with a post-hoc power analysis of 83.8%. We found that there was no statistically significant difference between groups when comparing WOMAC score and complications at short-term follow-up. Conclusions Our study provided more favourable clinical results for using Kinematics-Retaining implant in primary TKA. Further studies should focus on radiological and functional outcomes from mid- to long-term follow-up.

scholarly journals POS0277 ANABOLIC EFFECT OF LNA043, A NOVEL DISEASE-MODIFYING OSTEOARTHRITIS DRUG CANDIDATE: RESULTS FROM AN IMAGING-BASED PROOF-OF-CONCEPT TRIAL IN PATIENTS WITH FOCAL ARTICULAR CARTILAGE LESIONS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 363.2-363
Author(s):  
S. Trattnig ◽  
C. Scotti ◽  
D. Laurent ◽  
V. Juras ◽  
S. Hacker ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Weight Bearing ◽  
Cartilage Lesion ◽  
Cartilage Volume ◽  
Lesion Volume ◽  
Proof Of Concept ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions

Background:LNA043 is a modified, recombinant version of the human angiopoietin-like 3 (ANGPTL3) protein acting directly on cartilage-resident cells to transmit its cartilage anabolic effect. A first-in-human study previously demonstrated the favourable safety profile and the modulation of several pathways involved in cartilage homeostasis and osteoarthritis (OA)1. A previous proof-of-mechanism imaging study used high field (7 Tesla) magnetic resonance imaging (MRI) to show formation of hyaline-like tissue after a single injection of 20 mg LNA043 (unpublished data).Objectives:To evaluate non-invasively the chondro-regenerative capacity of multiple intra-articular (i.a.) injections of LNA043 in patients with articular cartilage lesions in the knee (NCT03275064).Methods:This was a randomised, double-blind, placebo (PBO)-controlled, proof-of-concept study in patients with a partial thickness cartilage lesion. In total, 58 patients (43 [20 mg LNA043]; 15 [PBO]), stratified by lesion type (condylar or patellar) were treated with 4 weekly i.a. injections. The primary endpoint was T2 relaxation time measurement as a marker of collagen fiber network, and cartilage lesion-volume was a secondary endpoint, both using 3-Tesla MRI. Assessments were performed at baseline, weeks (wks) 8, 16, 28 and 52 (the latter in 23/58 patients). While lesion-volume for the secondary endpoint was determined from manually segmented images, the cartilage volume of 21 sub-regions spanning the entire knee was also measured from 3D isotropic MR images employing an automated segmentation prototype software (MR Chondral Health 2.1 [MRCH], Siemens Healthcare)2. An exploratory analysis evaluated the treatment effect for the additive volume of the 3 subregions in the weight-bearing area of the medial femur.Results:No change in T2 relaxation time was detected between treatment and PBO groups. Manual segmentation showed continuous filling of the cartilage lesions up to wk 28 in LNA043-treated patients with femoral lesions (p=0.08, vs PBO) while no effect was detected for patients with patellar lesions. Given the limitations of measuring small, irregularly shaped lesions with manual image-analysis, the MRCH approach was used (Figure 1). In the medial femoral weight-bearing region, refilling was detected over time (Δ=123 mm3 at wk 28, N= 37, p= 0.05). No overgrowth was detected in the lateral femoral condyles without cartilage damage. The overall safety profile was favourable; only mild/moderate local reactions were reported, including a higher incidence of joint swelling (9.3% vs 0%) and arthralgia (11.6% vs 6.7%) for LNA043 vs PBO resolving spontaneously or with paracetamol/NSAIDs. No anti-drug antibodies were detected.Conclusion:Treatment with 4 weekly i.a. injections of 20 mg LNA043 resulted in regeneration of damaged cartilage in patients with femoral articular cartilage lesions. Automated measurement of cartilage volume in the femoral index region was able to detect a relevant treatment effect and was found to be more sensitive than the manual segmentation method. No sign of cartilage overgrowth was observed in healthy femoral regions. A Phase 2b study in patients with mild to moderate knee OA is in preparation.References:[1]Scotti et al. ACR Convergence 2020; Abstract #1483[2]Juras et al. Cartilage 2020; Sep 29:1-12Disclosure of Interests:Siegfried Trattnig: None declared, Celeste Scotti Shareholder of: Novartis, Employee of: Novartis, Didier Laurent Shareholder of: Novartis, Employee of: Novartis, Vladimir Juras: None declared, Scott Hacker Grant/research support from: Novartis, Brian Cole: None declared, Libor Pasa: None declared, Roman Lehovec: None declared, Pavol Szomolanyi: None declared, Esther Raithel Employee of: Siemens Healthcare GmbH, Franziska Saxer Shareholder of: Novartis, Employee of: Novartis, Jens Praestgaard Shareholder of: Novartis, Employee of: Novartis, Fabiola La Gamba Shareholder of: Novartis, Employee of: Novartis, José L. Jiménez Employee of: Novartis, David Sanchez Ramos Shareholder of: Novartis, Employee of: Novartis, Ronenn Roubenoff Shareholder of: Novartis, Employee of: Novartis, Matthias Schieker Shareholder of: Novartis, Employee of: Novartis

scholarly journals Treatment of articular cartilage lesions in the knee using high density autologous chondrocyte implantation: two years follow-up

2017 ◽  
Vol 25 ◽  
pp. S161
Author(s):  
E. Rodriguez-Iñigo ◽  
J. Lopez-Alcorocho ◽  
L. Aboli ◽  
I. Guillen-Vicente ◽  
M. Guillen-Vicente ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Autologous Chondrocyte Implantation ◽  
High Density ◽  
Cartilage Lesions ◽  
Chondrocyte Implantation ◽  
Articular Cartilage Lesions ◽  
Autologous Chondrocyte

Knee Cell-Based Cartilage Restoration

2019 ◽  
Vol 32 (02) ◽  
pp. 127-133 ◽  
Author(s):  
Dana Hensley ◽  
Adam Pickett
Keyword(s):  
Articular Cartilage ◽  
Cartilage Lesion ◽  
Clinical Results ◽  
Vascular Supply ◽  
Patient Specific ◽  
Physically Active ◽  
Cartilage Lesions ◽  
Nonsurgical Management ◽  
Biomimetic Scaffolds ◽  
Cartilage Restoration

AbstractAs our patients become more physically active at all ages, the incidence of injuries to articular cartilage is increasing causing significant pain and disability. The intrinsic healing response of articular cartilage is poor because of its limited vascular supply and capacity for chondrocyte division. Nonsurgical management for the focal cartilage lesion is successful in the majority of patients. Those patients who fail conservative management may be candidates for a cartilage reparative or reconstructive procedure. The type of treatment available depends on a multitude of lesion-specific and patient-specific variables. First-line therapies for isolated cartilage lesions have demonstrated good clinical results in the correct patient, but typically repair cartilage with fibrocartilage, which has inferior stiffness, inferior resilience, and poorer wear characteristics. Advances in cell-based cartilage restoration have provided the surgeon a means to address focal cartilage lesions utilizing mesenchymal stem cells, chondrocytes, and biomimetic scaffolds to restore hyaline cartilage.

scholarly journals Prevalence of Articular Cartilage Lesions and Surgical Clinical Outcomes in Football (Soccer) Players’ Knees: A Systematic Review

2016 ◽  
Vol 32 (7) ◽  
pp. 1466-1477 ◽  
Author(s):  
Renato Andrade ◽  
Sebastiano Vasta ◽  
Rocco Papalia ◽  
Hélder Pereira ◽  
J. Miguel Oliveira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Articular Cartilage ◽  
Clinical Outcomes ◽  
Soccer Players ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions

Articular cartilage lesions in female breeding swine

1993 ◽  
Vol 73 (4) ◽  
pp. 1005-1008 ◽  
Author(s):  
T. Nakano ◽  
F. X. Aherne
Keyword(s):  
Articular Cartilage ◽  
Key Words ◽  
Reproductive Performance ◽  
Articular Surface ◽  
Cartilage Lesion ◽  
Condylar Cartilage ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesion ◽  
Key Words Articular Cartilage ◽  
Articular Cartilage Lesions

Nineteen sows culled because of impaired reproductive performance were examined postmortem for abnormalities of the femoral condylar cartilage. All animals had lesions of varying severity, including irregular articular surface, surface tears, and erosion of the cartilage. The etiology of these cartilage lesions is discussed in relation to confinement. Key words: Articular cartilage lesion, osteoarthrosis, confinement, sows

scholarly journals Functional Results of Different Repair Techniques for Knee Articular Cartilage Lesions

2018 ◽  
Vol 69 (11) ◽  
pp. 3288-3291 ◽  
Author(s):  
Ciprian Alin Bardas ◽  
Gabri Jozsef Zsolt ◽  
Dragos Apostu ◽  
Daniel Oltean Dan ◽  
Gheorghe Tomoaia ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Treatment Options ◽  
Functional Results ◽  
Focal Lesions ◽  
Superior Result ◽  
Osteochondral Autograft ◽  
Cartilage Lesions ◽  
Osteochondral Autograft Transplantation ◽  
Functional Scores ◽  
Articular Cartilage Lesions

The articular cartilage lesions are frequent and highly affect the patient�s quality of life. Although remarkable progress in the treatment of focal lesions of articular cartilage were lately made, controversies still exist regarding the treatment options. The main purpose of this study was to evaluate and compare the preoperative and 6 months postoperative knee functional scores of patients undergoing arthroscopic repair of knee chondral lesions by: debridement, microfractures, osteochondral autograft transplantation and autologous matrix-induced chondrogenesis. Chondral reconstruction with collagen membranes and osteochondral autograft transplantation techniques showed a superior result at 6 months postoperatively compared to microfracture techniques and mechanical debridement.

Etiology of Cartilage Lesions Does Not Affect Clinical Outcomes of Patellofemoral Autologous Chondrocyte Implantation

Cartilage ◽  
2021 ◽  
pp. 194760352110309
Author(s):  
Alexandre Barbieri Mestriner ◽  
Jakob Ackermann ◽  
Gergo Merkely ◽  
Pedro Henrique Schmidt Alves Ferreira Galvão ◽  
Luiz Felipe Morlin Ambra ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Autologous Chondrocyte Implantation ◽  
Second Generation ◽  
Cartilage Lesion ◽  
Chondrocyte Implantation ◽  
Group 3 ◽  
Group 2 ◽  
Autologous Chondrocyte ◽  
Group 1

Objective To determine the relationship between cartilage lesion etiology and clinical outcomes after second-generation autologous chondrocyte implantation (ACI) in the patellofemoral joint (PFJ) with a minimum of 2 years’ follow-up. Methods A retrospective review of all patients that underwent ACI in the PFJ by a single surgeon was performed. Seventy-two patients with a mean follow-up of 4.2 ± 2.0 years were enrolled in this study and were stratified into 3 groups based on the etiology of PFJ cartilage lesions: patellar dislocation (group 1; n = 23); nontraumatic lesions, including chondromalacia, osteochondritis dissecans, and degenerative defects (group 2; n = 28); and other posttraumatic lesions besides patellar dislocations (group 3; n = 21). Patient’s mean age was 29.6 ± 8.7 years. Patients in group 1 were significantly younger (25.4 ± 7.9 years) than group 2 (31.7 ± 9.6 years; P = 0.025) and group 3 (31.5 ± 6.6 years; P = 0.05). Body mass index averaged 26.2 ± 4.3 kg/m2, with a significant difference between group 1 (24.4 ± 3.2 kg/m2) and group 3 (28.7 ± 4.5 kg/m2; P = 0.005). A clinical comparison was established between groups based on patient-reported outcome measures (PROMs) and failure rates. Results Neither pre- nor postoperative PROMs differed between groups ( P > 0.05). No difference was seen in survivorship between groups (95.7% vs. 82.2% vs. 90.5%, P > 0.05). Conclusion Cartilage lesion etiology did not influence clinical outcome in this retrospective study after second generation ACI in the PFJ. Level of Evidence Level III, retrospective comparative study.

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