scholarly journals Locally advanced cervical cancer: Preliminary results of the prospective randomized study

2003 ◽  
Vol 11 (3) ◽  
pp. 196-196
Author(s):  
Vesna Stankovic ◽  
Ivanka Marjanov ◽  
Slobodan Cikaric ◽  
Ljubomir Grzetic ◽  
Slobodanka Colakovic ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Regression ◽  
Randomized Study ◽  
Locally Advanced ◽  
Pathological Examination ◽  
Advanced Cervical Cancer ◽  
Early Complications ◽  
External Beam Irradiation ◽  
Preliminary Results ◽  
Locally Advanced Cervical Cancer

Background: The aim of this study is to show preliminary results of the randomized study that has been conducted among patients with advanced cervical cancer managed by loco-regional radiotherapy alone or combined treatment (radiotherapy with chemotherapy as radiosensitiser). Methods: From the beginning of 2002 till today 182 patients with locally advanced cervical cancer have been enrolled in the study (FIGO IIb-IVa). They have been treated by combined external beam irradiation (46Gy/22fr) and HDR brachyterapy (5x7Gy/A). Eighty-nine of them underwent the same radiotherapy regime with concomitant chemotherapy cisplatin (CDDP) 40mg per week). Median age for both groups were 52 years. Pathological examination showed: Squamous cell carcinoma in most cases 175, adeno Ca 6 and others 1. Effect of the therapy and early irradiation complications have been estimated by the tumor regression and toxicity grade. Results: Tumor regression have been occurred as complete response in 10.1% for RT group and for RT-HT group in 16.86%. Partial regression was for RT group 86% and for RT-HT group 87%. Early complications (haematological, urological and intestinal) in RT group were noted in 34% and in RT-HT group in 43% of patients. Conclusion: There was no benefit of RT-HT comparing to RT alone in the tumor regression of locally advanced cervical cancer. Early complications of combined therapy are more experienced than in RT group.

A randomized phase III trial of concurrent chemoradiotherapy in locally advanced cervical cancer: Preliminary results

2007 ◽  
Vol 104 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Vutisiri Veerasarn ◽  
Vicharn Lorvidhaya ◽  
Pimkhuan Kamnerdsupaphon ◽  
Nan Suntornpong ◽  
Supatra Sangruchi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Concurrent Chemoradiotherapy ◽  
Locally Advanced ◽  
Phase Iii ◽  
Advanced Cervical Cancer ◽  
Phase Iii Trial ◽  
Preliminary Results ◽  
Locally Advanced Cervical Cancer

scholarly journals Anatomic Location of PET-Positive Aortocaval Nodes in Patients with Locally Advanced Cervical Cancer: Implications for Surgical Staging

2012 ◽  
Vol 22 (7) ◽  
pp. 1203-1207 ◽  
Author(s):  
Michael Frumovitz ◽  
Pedro T. Ramirez ◽  
Homer A. Macapinlac ◽  
Ann H. Klopp ◽  
Alpa M. Nick ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Randomized Study ◽  
Locally Advanced ◽  
Stage Iv ◽  
Surgical Staging ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Pathologic Evaluation ◽  
Positron Emission ◽  
Number Of Patients

ObjectivePathologic evaluation of aortocaval nodes in patients with locally advanced cervical cancer in an effort to better tailor radiotherapy has gained popularity. We sought to determine which aortocaval nodes should be sampled during surgical staging procedures.MethodsFrom 2004 to 2011, 246 patients with locally advanced cervical cancer underwent positron emission tomography (PET) before definitive chemoradiation. We reviewed the imaging studies to determine the location of PET-positive aortocaval nodes in relationship to the inferior mesenteric artery (IMA).ResultsForty-two patients (17%) had PET images suggesting aortocaval metastasis. Ten patients had stage IB, 1 had stage IIA, 13 had stage IIB, 13 had stage IIIB, and 5 had stage IV disease. Of these 42 patients, 39 (93%) had FDG-avid pelvic nodes, 1 (2%) had PET-negative pelvic nodes but FDG-avid common iliac nodes, and 2 (5%) had direct spread to the aortocaval nodes. Three patients (7%) had FDG-avid aortocaval nodes above the IMA without FDG-avid nodes between the aortic bifurcation and IMA. All 3 of these patients also had FDG-avid nodes in the pelvis. Nineteen patients (45%) had FDG-avid nodes above and below the IMA, and 20 (48%) had FDG-avid nodes below the IMA only.ConclusionsThis hypothesis-generating study revealed that a small number of patients have PET-positive aortocaval nodes above the IMA only. For patients undergoing surgical staging for locally advanced cervical cancer, dissection to the renal vessels may be necessary. A future international, randomized study will prospectively evaluate the locations of pathologically positive aortocaval lymph nodes.

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