Specificity of cytokine profile and oxidant stress in patients with bronchial asthma

2006 ◽  
Vol 25 (2) ◽  
pp. 153-159
Author(s):  
Vladan Cosic ◽  
Vidosava Djordjevic ◽  
Gordana Bjelakovic ◽  
Jasmina Mimic-Oka ◽  
Dusica Pavlovic ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Oxidant Stress ◽  
Cytokine Profile

scholarly journals cytokine pRofile of peRipheRals blood of smoking patients with bRonchial asthma

2013 ◽  
Vol 6 (5) ◽  
pp. 44-47
Author(s):  
AlexAnder V. ZhestkoV ◽  
◽  
MArinA s. BlinchikoVA ◽  
Keyword(s):  
Bronchial Asthma ◽  
Cytokine Profile

scholarly journals FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH BRONCHIAL ASTHMA COMBINED WITH OBESITY

2018 ◽  
Vol 20 (6) ◽  
pp. 913-920
Author(s):  
M. V. Antonyuk ◽  
T. A. Gvozdenko ◽  
T. P. Novgorodtseva ◽  
T. I. Vitkina ◽  
B. I. Geltser ◽  
...  
Keyword(s):  
Body Weight ◽  
Bronchial Asthma ◽  
Cytokine Profile ◽  
Control Group ◽  
Observation Group ◽  
Normal Body ◽  
Asthma Patients ◽  
Normal Body Weight ◽  
Anti Inflammatory ◽  
Group 1

Combination of bronchial asthma (BA) and obesity is a difficult-to-control phenotype. Studies of inflammatory process with respect to severity of the disease are important for understanding the potential influence of obesity on the BA clinical course. The objective of this study was to determine cytokine profile in patients with mild BA combined with obesity. The study involved fifty-three patients with partially controlled mild BA. The patients were recruited as volunteers and signed an informed consent. The first observation group consisted of 27 asthma patients with normal body weight, the second observation group consisted of 26 patients with BA combined with obesity. A control group included 25 healthy volunteers. All the patients underwent clinical and laboratory examination in accordance with clinical standards for BA and obesity. The levels of TNFα, IL-2, IL-4, IL-6, IL-10 were evaluated in blood serum by means of flow cytometry. The ratios of proand anti-inflammatory cytokines (TNFα/IL-4, TNFα/IL-10, IL-6/IL-4, IL-6/IL-10) were calculated. Asthma patients with obesity (the 2nd group) had elevated levels of IL-2 over control group and group 1, by 38% and 44% respectively(p < 0.05). The concentration of proinflammatory cytokines TNFα and IL-6 was significanty increased in the both patient groups. Mean TNFα level was increased 2.5 times (p < 0.05), and IL-6 levels were increased by 30% (p < 0.05) in the 1st group as compared to the controls. TNFα and IL-6 concentrations showed a 3-fold increase over control values (p < 0.05) in the 2nd group. The level of antiinflammatory cytokine IL-4 was increased in patients with BA, independently of body mass. It should be noted that the concentration of this cytokine in obese patients was higher by 29% than in patients with normal body weight. IL-10 levels in patients from the 2nd group were reduced more than 2 times than in the 1st group. The patients of the 1st group showed a decrease in the IL-6/IL-10 index, in comparison with control parameters, thus indicative of an imbalance due to the elevation of the anti-inflammatory IL-10 cytokine. Among BA patients with obesity (group 2) the TNFα/IL-10 and IL-6/IL-10 indexes were higher than those of the control group (2.3- and 5.5-fold, respectively) and the group 1 (2.6- and 2.5-fold, respectively). Dynamics of these indexes confirms the systemic nature of inflammation and a predominance of non-atopic  inflammation in asthma patients with obesity. Thus, features of the cytokine profile in BA with obesity consist of a significant increase in pro-inflammatory IL-2, IL-6, TNFα cytokines, and a relative decrease in anti-inflammatory IL- 10 cytokine. The development of BA with obesity, even in mild-severity BA, is accompanied by development of a cytokine disbalance, which is typical for a mixed-type inflammation, with a prevalence of neutrophil inflammation. 

Biomarkers of oxidant stress in bronchial asthma

2006 ◽  
Vol 25 (4) ◽  
pp. 349-354
Author(s):  
Vladan Cosic ◽  
Ivana Stankovic ◽  
Milan Rancic ◽  
Lilika Zvezdanovic ◽  
Slavica Kundalic ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Oxidant Stress

Cytokine profile of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during seasonal H1N1 infection

Cytokine ◽  
2014 ◽  
Vol 69 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Shunji Hasegawa ◽  
Hiroyuki Wakiguchi ◽  
Seigo Okada ◽  
Yu Gui Kang ◽  
Nao Fujii ◽  
...  
Keyword(s):  
Mouse Model ◽  
Bronchoalveolar Lavage ◽  
Bronchial Asthma ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Cytokine Profile ◽  
H1n1 Infection

scholarly journals CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS

2017 ◽  
Vol 19 (3) ◽  
pp. 313-318 ◽  
Author(s):  
L. N. Sorokina ◽  
V. A. Ivanov ◽  
V. V. Lim ◽  
V. N. Mineev ◽  
V. I. Trofimov
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bronchial Asthma ◽  
Cytokine Profile

scholarly journals Assessment of cytokine profile and T-lymphocyte subpopulations in blood serum in children with allergic diseases of the respiratory system

2019 ◽  
Vol 16 (3) ◽  
pp. 52-60
Author(s):  
E V Prosekova ◽  
A I Turyanskaya ◽  
N G Plekhova ◽  
M S Dolgopolov ◽  
V A Sabynych
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Allergic Inflammation ◽  
Allergic Diseases ◽  
Cytokine Profile ◽  
T Helper ◽  
Serum Cytokine ◽  
Immunological Parameters ◽  
Enzymelinked Immunosorbent Assay ◽  
Level Of Significance

Expansion of the range of examined T-helper clones has determined more complex immune mechanisms for the implementation of allergic inflammation. Objective. To characterize the parameters and relationships between the serum cytokine profile and T-lympho-cyte subpopulation in peripheral blood of children with bronchial asthma and allergic rhinitis. Materials and methods. 150 children aged between 3-11 years old with bronchial asthma, and allergic rhinitis and 30 healthy volunteers were examined. Immunological parameters were assessed by flow cytometry, the concentration of serum interleukins and IgE were determined by means of enzymelinked immunosorbent assay. Statistical analysis was performed with «Statistica 10» program with a critical level of significance p

scholarly journals PLASMA Th1/Th2/Th17 CYTOKINE PROFILE AND CYTOKINE GENE POLYMORPHISMS (IL12B, IL13, IL31, IL33) IN ASTHMATIC CHILDREN: A MAGNETIC MULTIPLEX ASSAY

2021 ◽  
Vol 23 (4) ◽  
pp. 887-894
Author(s):  
M. V. Smolnikova ◽  
N. N. Gorbacheva ◽  
M. V. Shubina ◽  
S. Yu. Tereschenko
Keyword(s):  
Immune System ◽  
Disease Severity ◽  
Severe Asthma ◽  
Bronchial Asthma ◽  
Respiratory Infections ◽  
Cytokine Profile ◽  
Patient Specific ◽  
Cytokine Genes ◽  
Th17 Lymphocytes ◽  
Th17 Cytokine

The study of the bronchial asthma pathogenesis is an urgent problem due to its high prevalence and often developing uncontrolled severe ashma, including in childhood. The first signs of asthma development tend to occur in childhood, which causes deterioration in the patient’s quality of life and early disability. Since BA is a genetically mediated process, the severity of the disease is assumed to depend on the presence of a specific allelic variant in the mediator (e.g. cytokines) genes involved in the BA pathogenesis. The aim of this study was to search for immunogenetic markers of severe asthma in Slavs children living in Krasnoyarsk city. The quantitative indicators of the Th1/Th2/Th17-cytokine profile in children with bronchial asthma (BA) with varying disease severity, depending on the polymorphism of cytokine genes, using the method of multiplex analysis (xMAP), were first determined. Changes in the cytokine background in BA patients fit into the concept that a percentage of neutrophilic endotype, which performs its functions through Th1 and Th17-lymphocytes in severe asthma, increases. In addition, the cytokine profile data depending on concomitant acute respiratory infections were obtained. There was an imbalance when analyzing the cytokine plasma level, with a tendency to maintain the protective functions of the immune system among patients in remission. Distribution of cytokine genes was obtained: allelic variants of IL12B rs321220*G, IL13 rs1800925*C, IL31 rs7977932*C and IL33 rs7044343*T are the most common in the population sampling from Krasnoyarsk. The probability of the genotype association of cytokine genes (IL12B, IL13, IL31, IL33) with the state of the immune system in bronchial asthma with varying disease severity in children was studied: a significant association of the TT genotype IL12B rs3212220 with a low concentration of IL-12B was presented. Our data obtained can be used along with the previously obtained immunogenetic markers of severe and uncontrolled asthma in children for patient-specific prognosis of the disease nature. 

scholarly journals CYTOKINE PROFILE IS THE BIOMARKER OF THE SEVERITY OF BRONCHIAL ASTHMA

2017 ◽  
pp. 157-158
Author(s):  
V.V Voitsekhovsky ◽  
◽  
E.L. Lazutkina ◽  
N.N. Lazutkin ◽  
L.L. Lazarenko ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Cytokine Profile
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