scholarly journals Effect of serum lipid level change on 10-year coronary heart risk distribution estimated by means of seven different coronary risk scores during one-year treatment

2014 ◽  
Vol 67 (7-8) ◽  
pp. 208-215
Author(s):  
Nevena Eremic-Kojic ◽  
Mirjana Djeric ◽  
Jadranka Dejanovic
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Risk Scores ◽  
Coronary Risk ◽  
One Year ◽  
Heart Disease Risk

Introduction. This study was done in order to evaluate the effect of serum levels of total cholesterol, triglycerides, low-density lipoprotein- cholesterol and high-density lipoprotein-cholesterol on 10-year coronary heart disease risk distribution change. Material and Methods. This study included 110 subjects of both genders (71 female and 39 male), aged 29 to 73, treated at the Outpatient Department of Atherosclerosis Prevention, Centre for Laboratory Medicine, Clinical Centre Vojvodina. The 10-year coronary heart disease risk was estimated on first examination and after one-year treatment by means of Framingham, PROCAM and SCORE coronary risk scores and their modifications (Framingham Adult Treatment Panel III, Framingham Weibul, PROCAM NS and PROCAM Cox Hazards). Age, gender, systolic and diastolic blood pressure, smoking, positive family history and left ventricular hypertrophy are risk factors involved in the estimation of coronary heart disease besides lipid parameters. Results. There were no significant differences in nutritional status, smoking habits, systolic and diastolic pressure, and no development of diabetes mellitus or cardiovascular incidents during oneyear follow. However, a significant reduction in cholesterol level (p<0.001), triglycerides (p<0.001), low-density lipoprotein cholesterol (p<0.001) and an increase in high-density lipoprotein cholesterol (p<0.02) was present although therapeutic target values were not achieved. In addition, a significant increase was observed in the category of low 10-year coronary heart disease risk (Framingham- p<0.001; Framingham ATP III- p<0.001; Framingham Weibul- p<0.001; PROCAM- p<0.05; PROCAM NSp< 0.05; PROCAM Cox Hazards- p<0.001; SCORE- p<0.001) and a reduction in high-risk category (Framingham- p<0.001; Framingham ATP III- p<0.005; Framingham Weibul- p<0.005; PROCAM- p<0.001; PROCAM NS-p<0.001; PROCAM Cox Hazards- p<0.001; SCORE- p<0.005) in comparison with the risk at the beginning of the study. Conclusion. Our results show that the correction of lipid level after one-year treatment leads to a significant redistribution of 10-year coronary heart disease risk estimated by means of seven different coronary risk scores. This should stimulate patients and doctors to persist in prevention measures.

Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost

2005 ◽  
Vol 98 (5) ◽  
pp. 1619-1625 ◽  
Author(s):  
Gary O'Donovan ◽  
Andrew Owen ◽  
Steve R. Bird ◽  
Edward M. Kearney ◽  
Alan M. Nevill ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Heart Disease Risk ◽  
High Intensity ◽  
Disease Risk ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Moderate Intensity ◽  
Heart Disease Risk Factors ◽  
Heart Disease Risk

This study was designed to investigate the effect of exercise intensity on cardiorespiratory fitness and coronary heart disease risk factors. Maximum oxygen consumption (V̇o2 max), lipid, lipoprotein, and fibrinogen concentrations were measured in 64 previously sedentary men before random allocation to a nonexercise control group, a moderate-intensity exercise group (three 400-kcal sessions per week at 60% of V̇o2 max), or a high-intensity exercise group (three 400-kcal sessions per week at 80% of V̇o2 max). Subjects were instructed to maintain their normal dietary habits, and training heart rates were represcribed after monthly fitness tests. Forty-two men finished the study. After 24 wk, V̇o2 maxincreased by 0.38 ± 0.14 l/min in the moderate-intensity group and by 0.55 ± 0.27 l/min in the high-intensity group. Repeated-measures analysis of variance identified a significant interaction between monthly V̇o2 maxscore and exercise group ( F = 3.37, P < 0.05), indicating that V̇o2 maxresponded differently to moderate- and high-intensity exercise. Trend analysis showed that total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and fibrinogen concentrations changed favorably across control, moderate-intensity, and high-intensity groups. However, significant changes in total cholesterol (−0.55 ± 0.81 mmol/l), low-density lipoprotein cholesterol (−0.52 ± 0.80 mmol/l), and non-high-density lipoprotein cholesterol (−0.54 ± 0.86 mmol/l) were only observed in the high-intensity group (all P < 0.05 vs. controls). These data suggest that high-intensity training is more effective in improving cardiorespiratory fitness than moderate-intensity training of equal energy cost. These data also suggest that changes in coronary heart disease risk factors are influenced by exercise intensity.

Isolation of plasma small-dense low-density lipoprotein using a simple air-driven ultracentrifuge and quantification using immunassay of apolipoprotein B

2004 ◽  
Vol 42 (1) ◽  
Author(s):  
Valentine C. Menys ◽  
Yifen Liu ◽  
Michael I. Mackness ◽  
See Kwok ◽  
Muriel J. Caslake ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Heart Disease Risk ◽  
Apolipoprotein B ◽  
Disease Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Heart Disease Risk

AbstractSmall-dense low-density lipoprotein (SD-LDL) is associated with coronary heart disease risk. Current methods for its quantification are expensive, complex and time-consuming. Plasma was adjusted to a density (D) of 1.044 g/ml in a volume of 0.18 ml and centrifuged in a Beckman Airfuge at 160 000×

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