scholarly journals Necrotizing soft tissue infections of perianal and perineal region - still lethal infection

2017 ◽  
Vol 145 (1-2) ◽  
pp. 32-37
Author(s):  
Goran Stanojevic ◽  
Milica Nestorovic ◽  
Branko Brankovic ◽  
Miodrag Stojanovic ◽  
Milan Radojkovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Univariate Analysis ◽  
Tissue Infection ◽  
Fatality Rate ◽  
Duration Of Symptoms ◽  
Necrotizing Soft Tissue Infection ◽  
Stoma Creation ◽  
Perineal Region

Introduction/Objective. Necrotizing soft tissue infection is a life-threatening condition, characterized by widely spread necrosis of the skin, subcutaneous adipose tissue, fascia, and muscle. This study aimed to determine the risk factors associated with lethality due to necrotizing soft tissue infection of perianal and perineal region, for all patients surgically treated at a tertiary referral hospital. Methods. A retrospective review of 38 patients with necrotizing soft tissue infection of the perianal and perineal region, in the period between January 2007 and December 2014, was performed. We reviewed sex and age of the patients, the presence of known risk factors (diabetes mellitus, obesity, alcoholism), localization of necrotizing soft tissue infection, duration of symptoms, length of hospitalization, the number of necessary operations done, the performance of the stoma, and the outcome. We used logistic regression to identify the predictors of lethal outcome in a univariate analysis with estimated odds ratios and 95% confidence intervals. Results. There was a significantly higher fatality rate in the group of patients over 60 years of age (p < 0.05), with more than 10 days from the onset of symptoms to the treatment (p < 0.05), with a perianal localization (p < 0.05), and stoma creation (p < 0.05). The overall fatality rate was 18.4%. Conclusion. Patients? age, time passed between the onset of the symptoms and the initiation of the treatment, perianal localization, and stoma creation were related to higher lethality risk.

scholarly journals Necrotising soft tissue infections of the perianal and perineal region: Risk factors, diagnosis and treatment

2016 ◽  
Vol 63 (1) ◽  
pp. 101-109
Author(s):  
Goran Stanojevic ◽  
Vanja Pecic ◽  
Milica Nestorovic ◽  
Milan Radojkovic ◽  
Zoran Radovanovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Economic Status ◽  
Tissue Infection ◽  
Source Control ◽  
Necrotizing Soft Tissue Infection ◽  
Tissue Degeneration ◽  
Golden Standard ◽  
Threatening Condition

Necrotizing soft tissue infection is a life-threatening condition, characterized by extensive necrosis of skin, subcutaneous, fascia and muscle. 82% of patients exhibit some of the risk factors, such as diabetes mellitus, obesity and alcoholism, smoking, immunodeficiency, malnutrition or low socio-economic status. The necrotizing soft tissue infection is initially diagnosed by a clinical examination. The use of imaging, particularly computed tomography, represents a golden standard; the CT exam usually shows the presence fluid collections, abscess, adipose tissue degeneration and subcutaneous emphysema. The treatment of necrotizing soft tissue infection involves surgical debridement, drainage, wide incisions of the affected area, tissue decompression and application of broad-spectrum antimicrobial therapy. Despite existing modern methods of treatment, or the so-called principle of ?source control?, the mortality is still up to 51%. Necrotizing soft tissue infection is a very dangerous infection we should always be aware of, and treat it as early as possible.

Group G Streptococcal Necrotizing Soft Tissue Infection

2016 ◽  
Vol 78 (6) ◽  
pp. 644-649
Author(s):  
Eriko MAEHARA ◽  
Gaku TSUJI ◽  
Yukihiro MIZOTE ◽  
Naohide TAKEUCHI ◽  
Masutaka FURUE
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection

Can Paronychia Cause a Remote Necrotizing Soft Tissue Infection?

2011 ◽  
Vol 40 (1) ◽  
pp. e11-e13 ◽  
Author(s):  
Julian E. Losanoff ◽  
Anne E. Missavage ◽  
Paul Linneman ◽  
Boyd E. Terry
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection

scholarly journals Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection

2021 ◽  
pp. jim-2021-001837
Author(s):  
Morten Hedetoft ◽  
Peter Østrup Jensen ◽  
Claus Moser ◽  
Julie Vinkel ◽  
Ole Hyldegaard
Keyword(s):  
Oxidative Stress ◽  
Septic Shock ◽  
Soft Tissue ◽  
Hyperbaric Oxygen ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Heme Oxygenase 1 ◽  
Necrotizing Soft Tissue Infection ◽  
Before And After ◽  
Nitrite Nitrate

Necrotizing soft-tissue infection (NSTI) is a rare, severe, and fast-progressing bacterial infection associated with a high risk of developing sepsis or septic shock. Increasing evidence indicates that oxidative stress is crucial in the development and progression of sepsis, but its role in NSTI specifically has not been investigated. Some patients with NSTI receive hyperbaric oxygen (HBO2) treatment as the restoration of oxidative stress balance is considered an important mechanism of action, which HBO2 facilitates. However, a gap in knowledge exists regarding the effect of HBO2 treatment on oxidative stress in patients with NSTI. In the present observational study, we aimed to investigate HBO2 treatment effects on known markers of oxidative stress in patients with NSTI. We measured plasma myeloperoxidase (MPO), superoxide dismutase (SOD), heme oxygenase-1 (HO-1) and nitrite+nitrate in 80 patients with NSTI immediately before and after their first HBO2 treatment, and on the following day. We found that HBO2 treatment was associated with a significant increase in MPO and SOD by a median of 3.4 and 8.8 ng/mL, respectively. Moreover, we observed an HBO2 treatment-associated increase in HO-1 in patients presenting with septic shock (n=39) by a median of 301.3 pg/mL. All markers were significantly higher in patients presenting with septic shock compared to patients without shock, and all markers correlated with disease severity. High baseline SOD was associated with 90-day mortality. In conclusion, HBO2 treatment was associated with an increase in MPO and SOD in patients with NSTI, and oxidative stress was more pronounced in patients with septic shock.

scholarly journals A case of Apophysomyces trapeziformis necrotizing soft tissue infection

2013 ◽  
Vol 17 (12) ◽  
pp. e1240-e1242 ◽  
Author(s):  
Jose F. Echaiz ◽  
Carey-Ann D. Burnham ◽  
Thomas C. Bailey
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Necrotizing Soft Tissue Infection
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