scholarly journals Lung involvement in systemic connective tissue diseases

2008 ◽  
Vol 65 (9) ◽  
pp. 688-691
Author(s):  
Goran Plavec ◽  
Ilija Tomic ◽  
Sanela Bihorac ◽  
Gordana Kovacevic ◽  
Ljiljana Pavlica ◽  
...  
Keyword(s):  
Lung Function ◽  
Connective Tissue ◽  
Pulmonary Fibrosis ◽  
Chest Radiography ◽  
Respiratory Symptoms ◽  
Connective Tissue Diseases ◽  
Lung Involvement ◽  
Lung Function Tests ◽  
Treatment Regimens ◽  
Function Tests

Background/Aim. Systemic connective tissue diseases (SCTD) are chronic inflammatory autoimmune disorders of unknown cause that can involve different organs and systems. Their course and prognosis are different. All of them can, more or less, involve the respiratory system. The aim of this study was to find out the frequency of respiratory symptoms, lung function disorders, radiography and high-resolution computerized tomography (HRCT) abnormalities, and their correlation with the duration of the disease and the applied treatment. Methods. In 47 non-randomized consecutive patients standard chest radiography, HRCT, and lung function tests were done. Results. Hypoxemia was present in nine of the patients with respiratory symptoms (20%). In all of them chest radiography was normal. In five of these patients lung fibrosis was established using HRCT. Half of all the patients with SCTD had symptoms of lung involvement. Lung function tests disorders of various degrees were found in 40% of the patients. The outcome and the degree of lung function disorders were neither in correlation with the duration of SCTD nor with therapy used (p > 0.05 Spearmans Ro). Conclusion. Pulmonary fibrosis occurs in about 10% of the patients with SCTD, and possibly not due to the applied treatment regimens. Hypoxemia could be a sing of existing pulmonary fibrosis in the absence of disorders on standard chest radiography.

X-ray Darkfield Chest Radiography: Correlation of First Results from COPD-Patients with Lung Function Tests

2020 ◽  
Author(s):  
Gregor S. Zimmermann ◽  
Alexander A. Fingerle ◽  
Konstantin Willer ◽  
Wolfgang Noichl ◽  
Rafael Schick ◽  
...  
Keyword(s):  
Lung Function ◽  
Chest Radiography ◽  
Lung Function Tests ◽  
X Ray ◽  
Function Tests ◽  
Copd Patients ◽  
First Results

scholarly journals Byssinosis, respiratory symptoms and spirometric lung function tests in Tanzanian sisal workers

1978 ◽  
Vol 35 (2) ◽  
pp. 123-128 ◽  
Author(s):  
K. Y. Mustafa ◽  
A. S. Lakha ◽  
M. H. Milla ◽  
U. Dahoma
Keyword(s):  
Lung Function ◽  
Respiratory Symptoms ◽  
Lung Function Tests ◽  
Function Tests

Respiratory symptoms, lung function tests and airway responsiveness among crop farmers

2015 ◽  
Author(s):  
Saso Stoleski ◽  
Jovanka Karadzinska-Bislimovska ◽  
Jordan Minov ◽  
Dragan Mijakoski
Keyword(s):  
Lung Function ◽  
Respiratory Symptoms ◽  
Airway Responsiveness ◽  
Lung Function Tests ◽  
Function Tests

Lung Function Tests in Patients With Idiopathic Pulmonary Fibrosis

CHEST Journal ◽  
1997 ◽  
Vol 111 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Reinhard Erbes ◽  
Tom Schaberg ◽  
Robert Loddenkemper
Keyword(s):  
Lung Function ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Function Tests ◽  
Function Tests

Lung Involvement in Langerhans' Cell Histiocytosis: Prevalence, Clinical Features, and Outcome

PEDIATRICS ◽  
1992 ◽  
Vol 89 (3) ◽  
pp. 466-469
Author(s):  
S. Y. Ha ◽  
P. Helms ◽  
M. Fletcher ◽  
V. Broadbent ◽  
J. Pritchard
Keyword(s):  
Lung Function ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Similar Proportion ◽  
Lung Pathology ◽  
Lung Involvement ◽  
Lung Function Tests ◽  
Multisystem Disease ◽  
Female Ratio ◽  
Function Tests

In Langerhans' cell histiocytosis, the prognostic significance of pulmonary disease is controversial. The clinical and radiological features and lung function tests of Langerhans' cell histiocytosis patients presenting to a single tertiary referral center between 1981 and 1987 were reviewed. Age at diagnosis ranged from 2 weeks to 16 years (median 1.7 years) and the male-female ratio was 2.4:1. No child presented with lung involvement alone. In 18 (40%) of 45 patients with multisystem disease there was clinical and/or radiological evidence of lung pathology. Another 6 children (13%) with normal chest roentgenograms had abnormal lung function tests, suggesting subclinical ("occult") involvement. Those with overt lung disease tended to present at a younger than average age (median 0.6 years). The most common functional disturbance was reduced lung or respiratory compliance with reduced lung volumes. Patients with and without lung involvement showed a similar pattern of involvement of other organs, with skin and bone most commonly affected. Of the 45 children with multisystem disease, 38 (84%) survived 2 to 7 years after diagnosis; there was a similar proportion of deaths in children with and without lung involvement. It is concluded that lung involvement occurs in nearly half of young children with multisystem Langerhans' cell histiocytosis but does not adversely affect outcome.

scholarly journals Contribution of pulmonary function tests (PFTs) to the diagnosis and follow up of connective tissue diseases

2019 ◽  
Vol 14 ◽  
Author(s):  
Nicola Ciancio ◽  
Mauro Pavone ◽  
Sebastiano Emanuele Torrisi ◽  
Ada Vancheri ◽  
Domenico Sambataro ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Pulmonary Function Tests ◽  
Connective Tissue Diseases ◽  
Respiratory Pattern ◽  
Main Body ◽  
Lung Involvement ◽  
Function Tests

Introduction: Connective Tissue Diseases (CTDs) are systemic autoimmune conditions characterized by frequent lung involvement. This usually takes the form of Interstitial Lung Disease (ILD), but Obstructive Lung Disease (OLD) and Pulmonary Artery Hypertension (PAH) can also occur. Lung involvement is often severe, representing the first cause of death in CTD. The aim of this study is to highlight the role of Pulmonary Function Tests (PFTs) in the diagnosis and follow up of CTD patients. Main body: Rheumatoid Arthritis (RA) showed mainly an ILD with a Usual Interstitial Pneumonia (UIP) pattern in High-Resolution Chest Tomography (HRCT). PFTs are able to highlight a RA-ILD before its clinical onset and to drive follow up of patients with Forced Vital Capacity (FVC) and Carbon Monoxide Diffusing Capacity (DLCO). In the course of Scleroderma Spectrum Disorders (SSDs) and Idiopathic Inflammatory Myopathies (IIMs), DLCO appears to be more sensitive than FVC in highlighting an ILD, but it can be compromised by the presence of PAH. A restrictive respiratory pattern can be present in IIMs and Systemic Lupus Erythematosus due to the inflammatory involvement of respiratory muscles, the presence of fatigue or diaphragm distress. Conclusions: The lung should be carefully studied during CTDs. PFTs can represent an important prognostic tool for diagnosis and follow up of RA-ILD, but, on their own, lack sufficient specificity or sensitivity to describe lung involvement in SSDs and IIMs. Several composite indexes potentially able to describe the evolution of lung damage and response to treatment in SSDs are under investigation. Considering the potential severity of these conditions, an HRCT jointly with PFTs should be performed in all new diagnoses of SSDs and IIMs. Moreover, follow up PFTs should be interpreted in the light of the risk factor for respiratory disease related to each disease.

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