Gene Expression in the Squid Giant Axon: Neurotransmitter Modulation of RNA Transfer From Periaxonal Glia to the Axon

2002 ◽  
Vol 203 (2) ◽  
pp. 189-190 ◽  
Author(s):  
Antonio Giuditta ◽  
Maria Eyman ◽  
Barry B. Kaplan
Keyword(s):  
Gene Expression ◽  
Giant Axon ◽  
Squid Giant Axon

Neurofilaments and Paired Helical Filaments

1985 ◽  
Vol 43 ◽  
pp. 740-743
Author(s):  
J. Metuzals
Keyword(s):  
Animal Model ◽  
Posttranslational Modifications ◽  
Posttranslational Modification ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Squid Giant Axon ◽  
In Vitro Experiments ◽  
Thin Sections ◽  
Structural Relationships

It has been demonstrated that the neurofibrillary tangles in biopsies of Alzheimer patients, composed of typical paired helical filaments (PHF), consist also of typical neurofilaments (NF) and 15nm wide filaments. Close structural relationships, and even continuity between NF and PHF, have been observed. In this paper, such relationships are investigated from the standpoint that the PHF are formed through posttranslational modifications of NF. To investigate the validity of the posttranslational modification hypothesis of PHF formation, we have identified in thin sections from frontal lobe biopsies of Alzheimer patients all existing conformations of NF and PHF and ordered these conformations in a hypothetical sequence. However, only experiments with animal model preparations will prove or disprove the validity of the interpretations of static structural observations made on patients. For this purpose, the results of in vitro experiments with the squid giant axon preparations are compared with those obtained from human patients. This approach is essential in discovering etiological factors of Alzheimer's disease and its early diagnosis.

Injury-induced vesiculation and membrane redistribution in squid giant axon

1990 ◽  
Vol 1023 (3) ◽  
pp. 421-435 ◽  
Author(s):  
Harvey M. Fishman ◽  
Kirti P. Tewari ◽  
Philip G. Stein
Keyword(s):  
Giant Axon ◽  
Squid Giant Axon

Anterograde Transport of Peptide-Conjugated Fluorescent Beads in the Squid Giant Axon Identifies a Zip-Code for the Synapse

2004 ◽  
Vol 207 (2) ◽  
pp. 164-164
Author(s):  
Michael P. Conley ◽  
Marcus K. Jang ◽  
Joseph A. DeGiorgis ◽  
Elaine L. Bearer
Keyword(s):  
Giant Axon ◽  
Squid Giant Axon ◽  
Anterograde Transport ◽  
Fluorescent Beads ◽  
Zip Code

scholarly journals Determination of Transmembrane Protein with Diazotized (125I)-Iodosulfanilic Acid in the Squid Giant Axon

1978 ◽  
Vol 54 (6) ◽  
pp. 310-315 ◽  
Author(s):  
Tohru YOSHIOKA ◽  
Toshifumi TAKENAKA ◽  
Hidenori HORIE ◽  
Hiroko INOUE ◽  
Kimie INOMATA
Keyword(s):  
Transmembrane Protein ◽  
Giant Axon ◽  
Squid Giant Axon

scholarly journals Some effects of n-pentane on the sodium and potassium currents of the squid giant axon.

1981 ◽  
Vol 312 (1) ◽  
pp. 57-70 ◽  
Author(s):  
D A Haydon ◽  
J E Kimura
Keyword(s):  
Potassium Currents ◽  
Giant Axon ◽  
Squid Giant Axon ◽  
Sodium And Potassium

Ribosomes and polyribosomes are present in the squid giant axon: an immunocytochemical study

Neuroscience ◽  
1999 ◽  
Vol 90 (2) ◽  
pp. 705-715 ◽  
Author(s):  
J.R Sotelo ◽  
A Kun ◽  
J.C Benech ◽  
A Giuditta ◽  
J Morillas ◽  
...  
Keyword(s):  
Giant Axon ◽  
Squid Giant Axon ◽  
Immunocytochemical Study

Electrophysiological Properties of Squid Giant Axon Schwann Cells.

1991 ◽  
Vol 633 (1 Glial-Neurona) ◽  
pp. 607-609 ◽  
Author(s):  
N. JOAN ABBOTT ◽  
Y. PICHON ◽  
E. R. BROWN ◽  
I. INOUE ◽  
F. KUKITA ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Giant Axon ◽  
Squid Giant Axon ◽  
Electrophysiological Properties

scholarly journals Single sodium channels from the squid giant axon

1987 ◽  
Vol 52 (6) ◽  
pp. 1087-1090 ◽  
Author(s):  
F. Bezanilla
Keyword(s):  
Sodium Channels ◽  
Giant Axon ◽  
Squid Giant Axon ◽  
Single Sodium Channels

scholarly journals LONGITUDINAL IMPEDANCE OF THE SQUID GIANT AXON

1941 ◽  
Vol 24 (6) ◽  
pp. 771-788 ◽  
Author(s):  
Kenneth S. Cole ◽  
Richard F. Baker
Keyword(s):  
Sea Water ◽  
Low Frequency ◽  
Giant Axon ◽  
Squid Giant Axon ◽  
Dielectric Characteristics ◽  
Impedance Characteristics ◽  
Longitudinal Impedance ◽  
Electrode Length ◽  
Interpolar Distance ◽  
Inductive Reactance

Longitudinal alternating current impedance measurements have been made on the squid giant axon over the frequency range from 30 cycles per second to 200 kc. per second. Large sea water electrodes were used and the inter-electrode length was immersed in oil. The impedance at high frequency was approximately as predicted theoretically on the basis of the poorly conducting dielectric characteristics of the membrane previously determined. For the large majority of the axons, the impedance reached a maximum at a low frequency and the reactance then vanished at a frequency between 150 and 300 cycles per second. Below this frequency, the reactance was inductive, reaching a maximum and then approaching zero as the frequency was decreased. The inductive reactance is a property of the axon and requires that it contain an inductive structure. The variation of the impedance with interpolar distance indicates that the inductance is in the membrane. The impedance characteristics of the membrane as calculated from the measured longitudinal impedance of the axon may be expressed by an equivalent membrane circuit containing inductance, capacity, and resistance. For a square centimeter of membrane the capacity of 1 µf with dielectric loss is shunted by the series combination of a resistance of 400 ohms and an inductance of one-fifth henry.

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