Response to Eimeria tenella of Chickens Selected for High or Low Antibody Response and Differing in Haplotypes at the Major Histocompatibility Complex

1992 ◽  
Vol 36 (1) ◽  
pp. 49 ◽  
Author(s):  
E. A. Dunnington ◽  
W. B. Gross ◽  
A. Martin ◽  
P. B. Siegel
Keyword(s):  
Major Histocompatibility Complex ◽  
Antibody Response ◽  
Eimeria Tenella ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals Major histocompatibility complex recombinant R13 antibody response against bovine red blood cells

2020 ◽  
Vol 99 (10) ◽  
pp. 4804-4808
Author(s):  
N.G. Wilkinson ◽  
R.T. Kopulos ◽  
L.M. Yates ◽  
W.E. Briles ◽  
R.L. Taylor
Keyword(s):  
Major Histocompatibility Complex ◽  
Antibody Response ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals Immune response genes controlling responsiveness to major transplantation antigens. Specific major histocompatibility complex-linked defect for antibody responses to class I alloantigens.

1982 ◽  
Vol 155 (1) ◽  
pp. 303-320 ◽  
Author(s):  
G W Butcher ◽  
J R Corvalán ◽  
D R Licence ◽  
J C Howard
Keyword(s):  
Major Histocompatibility Complex ◽  
Antibody Response ◽  
Antibody Responses ◽  
Class I ◽  
Control Analysis ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Transplantation Antigens ◽  
Ir Genes

We have identified two major histocompatibility complex (MHC)-linked Ir genes that control the antibody response made by rats against class I major alloantigens. We have named these genes Ir-RT1Aa and Ir-RT1Ac. These Ir genes determine responsiveness of the immunized animal in a typical codominant fashion. There is no evidence so far for trans-complementation between low-responder haplotypes. Detailed studies of Ir-RT1Aa indicate that it controls the antibody response to at least two distinct alloantigenic determinants on RT1Aa molecules. These class I molecules thus behave like hapten-carrier conjugates when the response against the carrier is under Ir gene control. Analysis of the origin of alloantibody-forming cells in tetraparental radiation chimeras indicates that Ir-RT1Aa must control the provision of effective help to B cells. In many respects therefore, the properties of Ir-RT1Aa are broadly similar to those described for Ir genes controlling antibody responses to conventional antigens. The existence of apparently conventional Ir genes controlling the antibody response to major alloantigens strongly suggest that the processing of these transmembrane molecules by host antigen-presenting cells is a prerequisite for immune induction, and that it is the MHC of the responder rather than that of the allograft to which T helper cells are restricted in alloimmune responses in vivo.

scholarly journals Non-Major Histocompatibility Complex Control of Antibody Isotype and Th1 versus Th2 Cytokines during Experimental Infection of Mice with Mycobacterium avium

2001 ◽  
Vol 69 (3) ◽  
pp. 1708-1713 ◽  
Author(s):  
Vijaya Nagabhushanam ◽  
Christina Cheers
Keyword(s):  
Major Histocompatibility Complex ◽  
Antibody Response ◽  
Mycobacterium Avium ◽  
Enzyme Linked Immunosorbent Assay ◽  
Similar Response ◽  
Th2 Cytokines ◽  
Major Histocompatibility ◽  
Major Histocompatibility Complex Haplotype ◽  
Histocompatibility Complex ◽  
Ifn Γ

ABSTRACT Infection of different strains of mice withMycobacterium avium has revealed genetic control of the immunoglobulin isotype induced and of the balance between Th1 and Th2 cytokines. Female BALB/c or C57BL/10 mice were infected intranasally with 105 M. avium organisms. The antibody response was measured over 18 weeks by enzyme-linked immunosorbent assay and Western blotting, while numbers of cytokine-producing cells were assessed at 12 to 15 weeks by ELISPOT assay. Upon infection, C57BL/10 mice produced a clear Th1 response with strong gamma interferon (IFN-γ) production, no interleukin-4 (IL-4), and almost entirely immunoglobulin G2a (IgG2a) antibody. In contrast, BALB/c mice developed T cells producing IL-4, as well as those producing IFN-γ, while the antibody response was a mixture of IgG1 and IgG2a. Antibodies from BALB/c mice were also able to recognize a greater range of antigens than were C56BL/10 mice. B10D2 mice, which carry the BALB/c major histocompatibility complex haplotype on a C57BL/10 background, followed the C57BL/10 cytokine pattern. Mice infected withListeria monocytogenes did not show a similar response dichotomy.

scholarly journals The major histocompatibility complex-restricted response of recombinant inbred strains of mice to natural tick transmission of Borrelia burgdorferi.

1993 ◽  
Vol 177 (1) ◽  
pp. 9-17 ◽  
Author(s):  
W T Golde ◽  
T R Burkot ◽  
S Sviat ◽  
M G Keen ◽  
L W Mayer ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Borrelia Burgdorferi ◽  
Antibody Response ◽  
Recombinant Inbred ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Inbred Strains Of Mice ◽  
Bacterial Antigens

The causative agent of Lyme disease, Borrelia burgdorferi, is transmitted by ticks of the Ixodes ricinus complex. In this study, we report the antibody response of recombinant inbred strains of mice of the H-2, b, d, and k haplotypes, infected with B. burgdorferi as a result of exposure to infected I. dammini. The patterns of antibody response assayed by Western blot analysis indicate significant major histocompatibility complex (MHC) restriction to bacterial antigens within the first 2 mo of infection in mice. Other bacterial antigens induce a significant response across the MHC haplotypes tested when assayed on the same bacterial strain used to transmit the infection, but do not crossreact with the same proteins derived from heterologous strains of B. burgdorferi. No response to outer surface protein A was detected at any time during the 60-d period we analyzed this infection. A third group of bacterial antigens appear to generate a MHC-nonrestricted response, and this lack of restriction is maintained when assaying the crossreactivity of the response with other strains of B. burgdorferi. These proteins may provide more accurate diagnostic probes than those currently in use. Finally, there appears to be a significant difference in the expression of most bacterial antigens when the spirochete is cultured for many passages since the same strain of bacterium isolated from low-passage and high-passage preparations exhibit different banding patterns in Western blots when assayed with the same sera.

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