Fitting Cox's Regression Model to Survival Data using GLIM

Author(s):  
John Whitehead
2016 ◽  
Vol 5 (3) ◽  
pp. 9 ◽  
Author(s):  
Elizabeth M. Hashimoto ◽  
Gauss M. Cordeiro ◽  
Edwin M.M. Ortega ◽  
G.G. Hamedani

We propose and study a new log-gamma Weibull regression model. We obtain explicit expressions for the raw and incomplete moments, quantile and generating functions and mean deviations of the log-gamma Weibull distribution. We demonstrate that the new regression model can be applied to censored data since it represents a parametric family of models which includes as sub-models several widely-known regression models and therefore can be used more effectively in the analysis of survival data. We obtain the maximum likelihood estimates of the model parameters by considering censored data and evaluate local influence on the estimates of the parameters by taking different perturbation schemes. Some global-influence measurements are also investigated. Further, for different parameter settings, sample sizes and censoring percentages, various simulations are performed. In addition, the empirical distribution of some modified residuals are displayed and compared with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be extended to a modified deviance residual in the proposed regression model applied to censored data. We demonstrate that our extended regression model is very useful to the analysis of real data and may give more realistic fits than other special regression models. 


Biometrika ◽  
1986 ◽  
Vol 73 (3) ◽  
pp. 722-724 ◽  
Author(s):  
DOUGLAS G. ALTMAN ◽  
PER KRAGH ANDERSEN

Biometrics ◽  
1997 ◽  
Vol 53 (4) ◽  
pp. 1475 ◽  
Author(s):  
Per Kragh Andersen ◽  
John P. Klein ◽  
Kim M. Knudsen ◽  
Rene Tabanera y Palacios

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