Education and Development in Western Europe, The United States, and The U.S.S.R.: A Comparative Study. By Raymond Poignant. New York: Teachers College Press, 1969. xxx, 329 pp. $9.95.

Previous listings of African Studies offered at American universities have appeared each year in the Bulletin, the last one being in March 1964. The Editors thank all those who kindly supplied the information on which this summary is based, and they welcome any suggestions for improving the usefulness of this annual presentation or of extending the coverage. Later numbers of the Bulletin will include summaries of African Studies in Canada, Africa, Western Europe, the USSR, and Asia. The summary divides institutions into two main classes. First, there are those with a formally constituted Program, Center, or Committee, where African Studies has some institutionalized existence. Second, there is a group of universities which, while having no formal African Studies Program, nevertheless offer, through their regular departments, courses dealing with Africa. The latter list does not pretend to be exhaustive; there are many other institutions which might have been included, but we have no information on them at the present time. Students who are deciding to which school they should apply might bear in mind such factors as caliber of faculty, availability of fellowships (though the closing date for most applications for 1965/66 is already past), library facilities, other institutions in the vicinity, and research opportunities. Most scholars now agree that the area studies approach cannot exist without the more theoretical comparative approach, so that the presence of certain other scholars becomes very significant: in political science, for example, it would be advantageous to have available faculty who specialize in the comparative study of processes of modernization, or of revolutions, as well as those who concentrate on Africa as an area. Therefore, this guide merely outlines some of the main features of African Study Programs in the United States.

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A Companion to the History of the Book, 2nd edition. Simon Eliot and Jonathan Rose, eds.

RBM A Journal of Rare Books Manuscripts and Cultural Heritage ◽

10.5860/rbm.21.1.40 ◽

2020 ◽

Vol 21 (1) ◽

pp. 40

Author(s):

Jessie Sherwood

Keyword(s):

United States ◽

New York ◽

Latin America ◽

Western Europe ◽

Book History ◽

The United States ◽

History Of The Book ◽

Narrow Focus ◽

History Of

When he declared, “the physical book really has had a 500-year run” in a 2009 interview, Jeff Bezos might well be forgiven for thinking that the book began with Gutenberg. Histories of the book have tended to give the impression that it emerged with movable type and existed largely, if not exclusively, in Mainz, New York, London, Paris, Venice, and environs. The first edition to A Companion to the History of the Book, first published in 2007, was a welcome, albeit modest, corrective to this narrow focus. While the bulk of its attention was on print in Western Europe and the United States, it incorporated chapters on manuscripts, books in Asia and Latin America, and the Hebraic and Islamic traditions, broadening the scope of book history both chronologically and geographically.

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Dissemination and co-circulation of SARS-CoV2 subclades exhibiting enhanced transmission associated with increased mortality in Western Europe and the United States

10.1101/2020.07.13.20152959 ◽

2020 ◽

Author(s):

Yuan Hu ◽

Lee W Riley

Keyword(s):

United States ◽

New York ◽

Neutralizing Antibodies ◽

Western Europe ◽

Clinical Manifestations ◽

The United States ◽

Enhanced Transmission ◽

Co Morbidity ◽

Clinical Consequences ◽

Global Initiative

Mechanisms underlying the acute respiratory distress syndrome (ARDS)-like clinical manifestations leading to deaths in patients who develop COVID-19 remain uncharacterized. While multiple factors could influence these clinical outcomes, we explored if differences in transmissibility and pathogenicity of SARS-CoV2 variants could contribute to these terminal clinical consequences of COVID-19. We analyzed 34,412 SARS-CoV2 sequences deposited in the Global Initiative for Sharing All Influenza Data (GISAID) SARS-CoV2 sequence database to determine if regional differences in circulating strain variants correlated with increased mortality in Europe, the United States, and California. We found two subclades descending from the Wuhan HU-1 strain that rapidly became dominant in Western Europe and the United States. These variants contained nonsynonymous nucleotide mutations in the Orf1ab segment encoding RNA-dependent RNA polymerase (C14408T), the spike protein gene (A23403G), and Orf1a (G25563T), which resulted in non-conservative amino acid substitutions P323L, D614G, and Q57H, respectively. In Western Europe, the A23403G-C14408T subclade dominated, while in the US, the A23403G-C14408T-G25563T mutant became the dominant strain in New York and parts of California. The high cumulative frequencies of both subclades showed inconsistent but significant association with high cumulative CFRs in some of the regions. When the frequencies of the subclades were analyzed by their 7-day moving averages across each epidemic, we found co-circulation of both subclades to temporally correlate with peak mortality periods. We postulate that in areas with high numbers of these co-circulating subclades, a person may get serially infected. The second infection may trigger a hyperinflammatory response similar to the antibody-dependent enhancement (ADE) response, which could explain the ARDS-like manifestations observed in people with co-morbidity, who may not mount sufficient levels of neutralizing antibodies against the first infection. Further studies are necessary but the implication of such a mechanism will need to be considered for all current COVID-19 vaccine designs.

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