2022-P: Neonatal IL-4 Administration Decreases Body Fat Content and Weight and Improves Glucose Tolerance in Adulthood

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2022-P
Author(s):  
TAMMY YING ◽  
REBECCA A. SIMMONS
Keyword(s):  
Glucose Tolerance ◽  
Body Fat ◽  
Fat Content ◽  
Body Fat Content

scholarly journals Differential effects of prenatal stress and glucocorticoid administration on postnatal growth and glucose metabolism in rats

2009 ◽  
Vol 204 (3) ◽  
pp. 319-329 ◽  
Author(s):  
K L Franko ◽  
A J Forhead ◽  
A L Fowden
Keyword(s):  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Body Fat ◽  
Glycogen Content ◽  
Postnatal Growth ◽  
Female Offspring ◽  
Fat Content ◽  
Body Fat Content ◽  
Offspring Growth ◽  
Gluconeogenic Enzyme

Glucocorticoid administration during pregnancy programmes cardiovascular and metabolic functions in the adult offspring. Often, the control procedures are stressful per se and raise maternal glucocorticoid concentrations. This study compared the effects of maternal injection with dexamethasone (dex, 200 μg/kg) or saline with no treatment from 15 to 20 days of rat pregnancy on offspring growth and glucose metabolism. Near term, maternal corticosterone concentrations were higher in the saline-treated dams and lower in the dex-treated dams relative to untreated animals. In both male and female offspring, growth rate was measured for 14 weeks, and glucose tolerance was assessed between 12 and 13 weeks together with body fat content and plasma concentrations of insulin, leptin, and corticosterone between 14 and 15 weeks. Offspring liver was collected at different ages and was analyzed for glycogen content and gluconeogenic enzyme activity. Compared with untreated animals, both dex and saline treatments altered postnatal growth although adult body weight was unaffected. The two treatments had different effects on adult insulin concentrations and on hepatic glycogen content and gluconeogenic enzyme activities both pre- and postnatally. Relative to untreated animals, adult glucose tolerance was improved by maternal saline injection in males but not in females, while it was impaired in female offspring but not in male offspring of the dex-treated dams. Adult glucose tolerance was related to male body fat content but not to female body fat content. Dex and saline treatments of pregnant rats have differential sex-linked effects on the growth and glucose metabolism of their offspring, which indicates that the programming actions of natural and synthetic glucocorticoids may differ.

Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women

Diabetes ◽  
1992 ◽  
Vol 41 (9) ◽  
pp. 1151-1159 ◽  
Author(s):  
E. Bonora ◽  
S. Del Prato ◽  
R. C. Bonadonna ◽  
G. Gulli ◽  
A. Solini ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Body Fat ◽  
Fat Content ◽  
Body Fat Content ◽  
Total Body Fat ◽  
Total Body

scholarly journals Effect of ambient temperature on the productive and carcass traits of growing rabbits divergently selected for body fat content

animal ◽  
2020 ◽  
pp. 100096
Author(s):  
Z. Matics ◽  
Z. Gerencsér ◽  
R. Kasza ◽  
K. Terhes ◽  
I. Nagy ◽  
...  
Keyword(s):  
Ambient Temperature ◽  
Body Fat ◽  
Carcass Traits ◽  
Fat Content ◽  
Body Fat Content

Whole body fat: Content and distribution

2013 ◽  
Vol 73 ◽  
pp. 56-80 ◽  
Author(s):  
E.L. Thomas ◽  
J.A. Fitzpatrick ◽  
S.J. Malik ◽  
S.D. Taylor-Robinson ◽  
J.D. Bell
Keyword(s):  
Body Fat ◽  
Fat Content ◽  
Whole Body ◽  
Body Fat Content

scholarly journals Total Body Fat Content versus BMI in 4-Year-Old Healthy Swedish Children

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Elisabet Forsum ◽  
Eva Flinke Carlsson ◽  
Hanna Henriksson ◽  
Pontus Henriksson ◽  
Marie Löf
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Fat Content ◽  
Overweight And Obesity ◽  
Air Displacement Plethysmography ◽  
High Body ◽  
Childhood Overweight And Obesity ◽  
Body Fat Content ◽  
Measurement Session ◽  
Total Body

Childhood overweight and obesity, a worldwide problem, is generally identified using BMI (body mass index). However, this application of BMI has been little investigated in children below 5 years of age due to a lack of appropriate methods to assess body composition. Therefore, we used air displacement plethysmography (ADP) to study 4.4-year old boys and girls since this method is accurate in young children if they accept the requirements of the measurement. The purpose was to analyze the relationship between BMI and body fat in these children. Body composition was assessed in 76 (43 boys, 33 girls) of the 84 children brought to the measurement session. Boys and girls contained25.2±4.7and26.8±4.0% body fat, respectively. BMI-based cut-offs for overweight could not effectively identify children with a high body fat content. There was a significant (P<0.001) but weak (r=0.39) correlation between BMI and body fat (%). In conclusion, requirements associated with a successful assessment of body composition by means of ADP were accepted by most 4-year-olds. Furthermore, BMI-based cut-offs for overweight did not effectively identify children with a high body fatness and BMI explained only a small proportion of the variation in body fat (%) in this age group.

Body fat content and serum lipid levels

1980 ◽  
Vol 77 (2) ◽  
pp. 149-152 ◽  
Author(s):  
SHARLEEN MATTER ◽  
ARTHUR WELTMAN ◽  
BRYANT A. STAMFORD
Keyword(s):  
Body Fat ◽  
Serum Lipid ◽  
Fat Content ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Body Fat Content

Body Fat Content Does Not Affect Body's Maximal Muscle Strength

2016 ◽  
Vol 34 (2) ◽  
pp. 153 ◽  
Author(s):  
Jonguk Choi ◽  
Sunghoon Kim ◽  
Sunghoon Hur ◽  
Jongsam Lee
Keyword(s):  
Muscle Strength ◽  
Body Fat ◽  
Fat Content ◽  
Body Fat Content ◽  
Maximal Muscle Strength

The relationship between thyroid hormone and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus in China: A cross-sectional study

2020 ◽  
Author(s):  
Xia Sun ◽  
Liping Chen ◽  
Rongzhen Wu ◽  
Dan Zhang ◽  
Yinhui He
Keyword(s):  
Body Fat ◽  
Visceral Fat ◽  
Fat Content ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Body Fat Content ◽  
Male Patients ◽  
The Relationship ◽  
Visceral Fat Content

Abstract Background: This study compared the relationship between thyroid hormones and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus (T2DM) in China. Methods: A total of 64 male patients who were diagnosed as T2DM and 64 non-diabetic males who underwent health examination were matched according to age at a 1:1 ratio. Results: The 32 subjects in each sub-group showed differences in age, body mass index (BMI), mean arterial pressure, waist circumference, visceral fat content, body fat percentage, HbA1c, HOMA-IR, FT3, TSH, HDL-c, adiponectin, leptin, visfatin and TNF-α (all P < 0.05). In the overall population, FT3 was positively correlated with body fat percentage (r=0.21, P=0.02), and negatively correlated with HOMA-IR (r=-0.18, P=0.04) and visfatin (r=-0.47, P <0.01); TSH was positively correlated with body fat percentage (r=0.23, P=0.01). In the T2DM-OB group FT3 was positively correlated with BMI (r=0.45, P <0.05), visceral fat content (r=0.50, P <0.05), and body fat percentage (r=0.44, P <0.05); FT4 was positively correlated with visceral fat content (r=0.38, P <0.05); and TSH was positively correlated with HOMA-IR (r=0.39, P <0.05). Conclusion: TSH increased in obese people and FT3 was lower in patients with T2DM.

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