<a>Human brown adipose tissue (BAT) volume has been consistently claimed as
inversely associated with whole-body adiposity. However, recent advances in the
assessment of human BAT suggest that previously reported associations may have
been biased. The present cross-sectional study investigates the association of
BAT volume, mean radiodensity, and <sup>18</sup>F-fluordeoxyglucose (<sup>18</sup>F-FDG)
uptake (assessed via a static positron emission tomography-computerized
tomography (PET-CT) scan after a 2-hour personalized cold exposure) with whole-body
adiposity (measured by dual-energy X-ray absorptiometry) in 126 young adults (42
men / 84 women; 25±5 kg/m<sup>2</sup>). BAT volume, but not <sup>18</sup>F-FDG
uptake, was positively associated with body mass index (BMI), fat mass, and visceral
adipose tissue mass in men, but not in women. These associations were
independent of the date when the PET-CT was performed, insulin sensitivity and
body surface area. BAT mean radiodensity, an inverse proxy of BAT fat content,
was negatively associated </a>was with BMI, waist circumference, fat mass and visceral
adipose tissue mas in men and with percentage fat mass in women. These results refute the
widely held belief that human BAT volume is reduced in obese persons, at least
in young adults, and suggest that it might even be the opposite in young men.
Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women
