scholarly journals Potential Benefits and Harms of Gastric Bypass Surgery in Obese Individuals With Type 1 Diabetes: A Nationwide, Matched, Observational Cohort Study

Diabetes Care ◽  
2020 ◽  
Vol 43 (12) ◽  
pp. 3079-3085
Author(s):  
Gudrun Höskuldsdóttir ◽  
Jan Ekelund ◽  
Mervete Miftaraj ◽  
Ville Wallenius ◽  
Johan Ottosson ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Observational Cohort Study ◽  
Potential Benefits ◽  
Observational Cohort

The Pros and Cons of Gastric Bypass Surgery in Obese Individuals with Type 2 Diabetes—Nationwide, Matched, Observational Cohort Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 131-OR
Author(s):  
VASILEIOS LIAKOPOULOS ◽  
ANN-MARIE SVENSSON ◽  
INGMAR NASLUND ◽  
BJORN ELIASSON
Keyword(s):  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Cohort Study ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Observational Cohort Study ◽  
Observational Cohort ◽  
Pros And Cons

scholarly journals Potential benefits and harms of gastric bypass surgery in obese individuals with type 1 diabetes: a nationwide, matched, observational cohort study

2020 ◽  
Author(s):  
Gudrun Höskuldsdóttir ◽  
Jan Ekelund ◽  
Mervete Miftaraj ◽  
Ville Wallenius ◽  
Johan Ottosson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Bariatric Surgery ◽  
Substance Abuse ◽  
Gastric Bypass ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery

<b>Objective:</b> To study the potential long‑term benefits and possible complications of bariatric surgery in patients with type 1 diabetes. <p> </p> <p><b>Research Design and Methods:</b> In this register‑based nationwide cohort study we compared individuals with T1D and obesity that underwent Roux‑en‑Y gastric bypass surgery (RYGB) with patients with T1D and obesity matched for age, gender, BMI and calendar time that did not undergo surgery. By linking the Swedish National Diabetes Register and Scandinavian Obesity Surgery Registry study individuals were included between 2007 and 2013. Outcomes examined included all-cause mortality, cardiovascular disease, stroke, heart failure and hospitalization for serious hypo‑ or hyperglycemic events, amputation, psychiatric disorders, changes in kidney function and substance abuse.</p> <p> </p> <p><b>Results:</b> We identified 387 individuals that had undergone RYGB and 387 controls. Follow‑up for hospitalization was up to 9 years. Analysis showed lower risk for cardiovascular disease (HR 0.43, 95% CI 0.20‑0.9), cardiovascular death (HR 0.15, 95% CI 0.03-0.68), hospitalization for heart failure (HR 0.32, 95% CI 0.15‑0.67) and stroke (HR 0.18, 95% CI 0.04-0.82) for the RYGB group. There was a higher risk for serious hyperglycemic events (HR 1.99, 95% CI 1.07‑3.72) and substance abuse (HR 3.71, 95% CI 1.03-3.29) after surgery. </p> <p> </p> <p><b>Conclusion:</b> This observational study suggests bariatric surgery may yield similar benefits on risk for cardiovascular outcomes and mortality in patients with T1D and obesity as for patients with type 2 diabetes. However, some potential serious adverse effects suggest need for careful monitoring of such patients after surgery. </p>

scholarly journals Potential benefits and harms of gastric bypass surgery in obese individuals with type 1 diabetes: a nationwide, matched, observational cohort study

2020 ◽  
Author(s):  
Gudrun Höskuldsdóttir ◽  
Jan Ekelund ◽  
Mervete Miftaraj ◽  
Ville Wallenius ◽  
Johan Ottosson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Bariatric Surgery ◽  
Substance Abuse ◽  
Gastric Bypass ◽  
Type 1 Diabetes ◽  
Cohort Study ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery

<b>Objective:</b> To study the potential long‑term benefits and possible complications of bariatric surgery in patients with type 1 diabetes. <p> </p> <p><b>Research Design and Methods:</b> In this register‑based nationwide cohort study we compared individuals with T1D and obesity that underwent Roux‑en‑Y gastric bypass surgery (RYGB) with patients with T1D and obesity matched for age, gender, BMI and calendar time that did not undergo surgery. By linking the Swedish National Diabetes Register and Scandinavian Obesity Surgery Registry study individuals were included between 2007 and 2013. Outcomes examined included all-cause mortality, cardiovascular disease, stroke, heart failure and hospitalization for serious hypo‑ or hyperglycemic events, amputation, psychiatric disorders, changes in kidney function and substance abuse.</p> <p> </p> <p><b>Results:</b> We identified 387 individuals that had undergone RYGB and 387 controls. Follow‑up for hospitalization was up to 9 years. Analysis showed lower risk for cardiovascular disease (HR 0.43, 95% CI 0.20‑0.9), cardiovascular death (HR 0.15, 95% CI 0.03-0.68), hospitalization for heart failure (HR 0.32, 95% CI 0.15‑0.67) and stroke (HR 0.18, 95% CI 0.04-0.82) for the RYGB group. There was a higher risk for serious hyperglycemic events (HR 1.99, 95% CI 1.07‑3.72) and substance abuse (HR 3.71, 95% CI 1.03-3.29) after surgery. </p> <p> </p> <p><b>Conclusion:</b> This observational study suggests bariatric surgery may yield similar benefits on risk for cardiovascular outcomes and mortality in patients with T1D and obesity as for patients with type 2 diabetes. However, some potential serious adverse effects suggest need for careful monitoring of such patients after surgery. </p>

scholarly journals Metabolic outcomes 2 years following gastric bypass surgery in people with type 2 diabetes: an observational cohort study

QJM ◽  
2014 ◽  
Vol 107 (9) ◽  
pp. 721-726 ◽  
Author(s):  
F. Behbehani ◽  
B. J. Ammori ◽  
J. P. New ◽  
L. K. M. Summers ◽  
H. Soran ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Cohort Study ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Observational Cohort Study ◽  
Metabolic Outcomes ◽  
Observational Cohort

scholarly journals Continuous glucose monitoring in pregnant women with type 1 diabetes: an observational cohort study of 186 pregnancies

Diabetologia ◽  
2019 ◽  
Vol 62 (7) ◽  
pp. 1143-1153 ◽  
Author(s):  
Karl Kristensen ◽  
Linda E. Ögge ◽  
Verena Sengpiel ◽  
Karin Kjölhede ◽  
Annika Dotevall ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Pregnant Women ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Observational Cohort Study ◽  
Observational Cohort

scholarly journals Clinical Effects and Safety of Direct-Acting Insulin Analogs in Patients with Type 1 Diabetes: A Nation-Wide Observational Cohort Study

2016 ◽  
Vol 7 (3) ◽  
pp. 561-573 ◽  
Author(s):  
Vincent Lak ◽  
Ann-Marie Svensson ◽  
Mervete Miftaraj ◽  
Stefan Franzén ◽  
Björn Eliasson
Keyword(s):  
Type 1 Diabetes ◽  
Cohort Study ◽  
Observational Cohort Study ◽  
Clinical Effects ◽  
Insulin Analogs ◽  
Acting Insulin ◽  
Observational Cohort ◽  
Direct Acting
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