Objective:
<br>To evaluate associations between diabetic peripheral neuropathy
(DPN) and urological complications in men and women with type 1
diabetes.
<br>ResearchDesignandMethods:
<br>Measurements of DPN at EDIC years 1, 13/14 and 17 and urological
complications at EDIC year 17 were examined in 635 men (mean age 51.6
yrs, diabetes duration 29.5 yrs) and 371 women (mean age 50.6 yrs and
diabetes duration 29.8 yrs) enrolled in the Diabetes Control and
Complications Trial/Epidemiology of Diabetes Interventions and
Complications (DCCT/EDIC) study. DPN was defined by symptoms, signs and
abnormal electrophysiology, or by abnormal Michigan Neuropathy Screening
Instrument (MNSI) examination or questionnaire scores.
<br>Results:
<br>Erectile dysfunction (ED) in combination with lower urinary tract
symptoms (LUTS) was reported in 15% of men, and female sexual
dysfunction (FSD), LUTS and urinary incontinence (UI) in 16% of women.
When controlling for age, drinking status, BMI, depression, DCCT/EDIC
time-weighted mean HbA1c, microalbuminuria, hypertension, triglycerides
and statin medication use, men with confirmed DPN at EDIC year 13/14 had
a higher odds of ED/LUTS at year 17 compared to men without DPN
(OR=3.52 95% CI 1.69,7.31). Men with DPN based on abnormal MNSI
examination or questionnaire scores had significantly higher odds of ED
and LUTS at year 17 than men without DPN at all time points. There were
no significant differences in DPN between women reporting both FSD and
LUTS/UI compared to those without FSD or LUTS/UI at EDIC year 17.
<br>Conclusions:
<br>In long-standing T1D, DPN is associated with the later development of urological complications in men.
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Diabetic Peripheral Neuropathy and Urological Complications in Type 1 Diabetes: Findings From the Epidemiology of Diabetes Interventions and Complications Study
