The relationship of intracytoplasmic movement of beta granules to insulin release in monolayer-cultured pancreatic beta-cells

Diabetes ◽  
1980 ◽  
Vol 29 (12) ◽  
pp. 953-959 ◽  
Author(s):  
Y. Kanazawa ◽  
S. Kawazu ◽  
M. Ikeuchi ◽  
K. Kosaka
Keyword(s):  
Beta Cells ◽  
Insulin Release ◽  
Pancreatic Beta Cells ◽  
Relationship Of ◽  
The Relationship

Tetraethylammonium modifies gap junctions between pancreatic beta-cells

1981 ◽  
Vol 240 (3) ◽  
pp. C116-C120 ◽  
Author(s):  
M. S. Sheppard ◽  
P. Meda
Keyword(s):  
Beta Cell ◽  
Gap Junctions ◽  
Beta Cells ◽  
Insulin Release ◽  
Pancreatic Beta Cells ◽  
Freeze Fracture ◽  
Potassium Conductance ◽  
Median Number ◽  
Rat Islets Of Langerhans ◽  
Gap Junctional

Gap junctions between pancreatic beta-cells were quantitatively assessed in freeze-fracture replicas of isolated rat islets of Langerhans incubated for 90 min with or without the potassium conductance blocker tetraethylammonium (TEA). The results show that TEA increases the median number of particles per beta-cell gap junction but not the frequency of gap junctions at both nonstimulating and threshold-stimulating concentrations of glucose. TEA increased the relative gap junctional area at both concentrations of glucose. TEA had no effect on insulin release at a basal concentration of glucose but potentiated that release at the threshold glucose level. Thus TEA modifies beta-cell gap junctions independently of its effect on insulin release. However, the junctional changes observed were greater when insulin release was also elevated.

2089268 Ultrasound Stimulation of Insulin Release From Pancreatic Beta Cells

2015 ◽  
Vol 41 (4) ◽  
pp. S65 ◽  
Author(s):  
Ivan Mauricio Suarez Castellanos ◽  
Aleksandar Jeremic ◽  
Vesna Zderic
Keyword(s):  
Beta Cells ◽  
Insulin Release ◽  
Pancreatic Beta Cells ◽  
Ultrasound Stimulation ◽  
Stimulation Of

scholarly journals Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

Diabetologia ◽  
2010 ◽  
Vol 53 (5) ◽  
pp. 924-936 ◽  
Author(s):  
G. Sun ◽  
A. I. Tarasov ◽  
J. McGinty ◽  
A. McDonald ◽  
G. da Silva Xavier ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Beta Cells ◽  
Insulin Release ◽  
Pancreatic Beta Cells ◽  
Amp Activated Protein Kinase

scholarly journals Glucose induces oscillatory Ca2+ signalling and insulin release in human pancreatic beta cells

Diabetologia ◽  
1994 ◽  
Vol 37 (S2) ◽  
pp. S11-S20 ◽  
Author(s):  
B. Hellman ◽  
E. Gylfe ◽  
P. Bergsten ◽  
E. Grapengiesser ◽  
P. E. Lund ◽  
...  
Keyword(s):  
Beta Cells ◽  
Insulin Release ◽  
Pancreatic Beta Cells
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