Lipoprotein(a) in Diabetic Patients with and Without Chronic Renal Failure

Diabetes Care ◽  
1992 ◽  
Vol 15 (8) ◽  
pp. 976-979 ◽  
Author(s):  
P. J. Guillausseau ◽  
J. Peynet ◽  
P. Chanson ◽  
A. Legrand ◽  
J. J. Altman ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Diabetic Patients ◽  
Lipoprotein A

Correction formula for carbamylated haemoglobin in diabetic uraemic patients

2001 ◽  
Vol 38 (2) ◽  
pp. 115-119 ◽  
Author(s):  
A M A Hammouda ◽  
G E Mady
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Free Amino ◽  
Urea Concentration ◽  
Diabetic Patients ◽  
Amino Groups ◽  
Correction Formula ◽  
Significant Difference ◽  
And Control

The measurement of carbamylated haemoglobin is a useful indicator of uraemic state during the preceding few weeks in patients with renal failure. In diabetic uraemic patients with hyperglycaemia, glycation of haemoglobin may interfere with its carbamylation, as both reactions involve the free amino groups of the protein. The aim of this study was to investigate the carbamylation of haemoglobin in the presence of hyperglycaemia. The study included 29 patients with chronic renal failure on regular haemodialysis, 14 diabetic and 15 non-diabetic patients, and 10 healthy controls. We found a significant correlation between the degree of haemoglobin carbamylation and mean blood urea concentration in both uraemic and control subjects. Carbamylation of haemoglobin was higher in both diabetic and non-diabetic chronic renal failure patients, but there were no significant differences between the groups regarding mean blood urea concentration or level of haemoglobin carbamylation. Carbamylated haemoglobin per unit of blood urea concentration was lower in the diabetic patients. Using a correction formula to account for the degree of haemoglobin glycation, there was no longer a significant difference in carbamylation per unit of blood urea concentration. In vitro incubation of red blood cells from six healthy and six diabetic non-uraemic patients in 70mmol/L urea showed a significantly lower carbamylation in the diabetic patients, but there was no significant difference when using corrected carbamylated haemoglobin values. We conclude that glycation of haemoglobin affects its carbamylation and that monitoring of uraemia in a diabetic patient necessitates the use of carbamylated haemoglobin value corrected for the degree of glycation.

ANALYSIS OF THE ROLE OF MTHFR C677T AND TGF-BETA C-509T POLYMORPHISMS IN TYPE 1 DIABETIC PATIENTS WITH CHRONIC RENAL FAILURE

2008 ◽  
Vol 9 (1) ◽  
pp. 109
Author(s):  
C.I. Tecuceanu ◽  
D. Cimponeriu ◽  
P. Apostol ◽  
M. Stavarachi ◽  
M. Toma ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Mthfr C677t ◽  
Diabetic Patients ◽  
Tgf Beta ◽  
Type 1 Diabetic Patients

scholarly journals Lipoprotein (a) in Chronic Renal Failure Patients Undergoing Hemodialysis: Does It Have an Independent Role in the Development of Further Cardiovascular Complications?

Nephron ◽  
1993 ◽  
Vol 65 (4) ◽  
pp. 644-645 ◽  
Author(s):  
Jorge del Cura ◽  
Antonio Gil-Paraiso ◽  
Luis Borque ◽  
Maria-Eugenia Carazo ◽  
Carlos Maside ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiovascular Complications ◽  
Lipoprotein A

scholarly journals Increased Lipoprotein (a) and Its Relationships with Other Parameters of Lipoprotein Metabolism in Chronic Renal Failure Treated by Hemodialysis.

1997 ◽  
Vol 38 (1) ◽  
pp. 83-89 ◽  
Author(s):  
M. Ramazan YIGITOGLU ◽  
M. Fevzi POLAT ◽  
Fatih AKÇAY ◽  
Zeki ARI ◽  
B. Sami UYANIK ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Lipoprotein Metabolism ◽  
Lipoprotein A

scholarly journals EFFECT OF HEMODIALYSIS ON MACULAR THICKENSS IN PATIENTS OF CHRONIC RENAL FAILURE WITH DIABETIC MACULAR EDEMA

2020 ◽  
pp. 1-3
Author(s):  
Kinjal Trivedi ◽  
Charmi Madhani ◽  
Saumil Parikh ◽  
Somesh Aggarwal
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Linear Regression Analysis ◽  
Macular Thickness ◽  
Serum Osmolality ◽  
P Value ◽  
Diabetic Patients ◽  
Before And After

Introduction: End stage renal disease (ESRD) patients undergoing hemodialysis (HD) have higher incidence of diabetic retinopathy (DR) and diabetic macular edema. Optical coherence tomography (OCT) which both diagnoses and quantifies degree of macular edema is gold standard for evaluating macular thickness. Materials and methods: We studied 30 patients, with DR who were treated with hemodialysis for ESRD. All patients underwent OCT examination 30 minutes before and after a hemodialysis session. Blood pressure (BP), weight, serum osmolality, glycemic hemoglobin and albumin levels were measured before and after hemodialysis. Student’s t-test and linear regression analysis test were used to analyze data. SPSS version 21.0 system was used for all statistical analyses and p value <0.05 was accepted as statistically significant. Results: In our study, BCVA failed to change significantly after the HD. Central and average macular thickness decreased by 3.49% and 1.61% respectively, both were statistically significant. Changes in maximum, central and average macular thickness, as well as in total macular volume were found to be significantly affected by changes in serum osmolality (p=0.04, 0.002, 0.02 and 0.03, respectively).We found no significant changes in maximum/average macular thickness with changes in total body weight or in mean arterial pressure after HD. Conclusion: Hemodialysis significantly decreases maximum macular thickness assessed by OCT in chronic renal failure diabetic patients with macular edema with no change in BCVA. Osmolality changes after hemodialysis were significantly associated with macular thickness.

scholarly journals Significance of lipoprotein(a) in diabetic chronic renal failure

2017 ◽  
Vol 5 (9) ◽  
pp. 3856
Author(s):  
Vasanthan M.
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
The Other ◽  
Lipoprotein A ◽  
Positive Correlation ◽  
Duration Of Diabetes

Background: Diabetes mellitus, is a metabolic disease with an alarming prevalence worldwide. When uncontrolled, this can result in diseases such as chronic renal failure by various atherogenic factors including lipoprotein(a). Aim was to estimate the level of lipoprotein(a) in diabetic chronic renal failure patients and to correlate with healthy controls.Methods: 30 non-diabetic subjects and 30 diabetic CRF patients were included in the study. Lipoprotein(a) was estimated by immunoturbidimetric method and the other parameters by their respective methods in biochemistry auto-analyzer.Results: It was found from the study that there is a positive correlation of lipoprotein(a) levels with the duration of diabetes and was progressive with the diabetic complications.Conclusions: Lipoprotein(a) is responsible for atherogenic events in CRF patients.

Sign in / Sign up

Export Citation Format

Share Document