scholarly journals Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck

2021 ◽  
Author(s):  
Alet J.G. Leus ◽  
Marjolijn S. Haisma ◽  
Jorrit B. Terra ◽  
Gilles F.H. Diercks ◽  
Marloes S. Van Kester ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Tumour Diameter ◽  
Progression Of Disease ◽  
Tumour Characteristics

Guidelines for cutaneous squamous cell carcinoma of the head and neck do not take the age of the patient into account, but instead assume equal tumour characteristics and prognostic factors for poor outcome in younger and elderly patients. The aim of this study was to compare tumour characteristics of younger (< 75 years) and elderly (≥ 75 years) patients and identify age-specific risk factors for progression of disease, comprising local recurrence, nodal metastasis and distant metastasis. Patient and tumour characteristics were compared using χ2 or Fisher’s exact tests. Multivariable competing risk analyses were performed to compare risk factors for progression of disease, incorporating the risk of dying before developing progression of disease. A total of 672 patients with primary cutaneous squamous cell carcinoma of the head and neck were retrospectively included. Larger tumour diameter, worse differentiation grade and deeper invasion were observed in older patients. In elderly patients, but not in younger patients, tumour diameter ≥ 40 mm, moderate differentiation grade and an invasion depth ≥ 2 mm were independent risk factors for progression of disease.

scholarly journals Metastatic cutaneous squamous cell carcinoma of the head and neck: Characteristics of the primary and poor prognostic factors

2012 ◽  
Vol 10 (8) ◽  
pp. S5
Author(s):  
David Walker ◽  
Rajeev Mathew ◽  
Tatiana Gutierrez ◽  
Reza Nouraei ◽  
Patrick McCabe ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma

scholarly journals Cutaneous squamous cell carcinoma (SCC) of the head and neck: Risk factors of overall and recurrence-free survival

2010 ◽  
Vol 46 (9) ◽  
pp. 1563-1572 ◽  
Author(s):  
Athanassios Kyrgidis ◽  
Thrasivoulos George Tzellos ◽  
Nikolaos Kechagias ◽  
Anna Patrikidou ◽  
Persa Xirou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Recurrence Free Survival ◽  
Free Survival

scholarly journals Analysis of selected risk factors for nodal metastases in head and neck cutaneous squamous cell carcinoma

2014 ◽  
Vol 272 (10) ◽  
pp. 3007-3012 ◽  
Author(s):  
Mateusz Szewczyk ◽  
Jakub Pazdrowski ◽  
Paweł Golusiński ◽  
Aleksandra Dańczak-Pazdrowska ◽  
Sławomir Marszałek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Nodal Metastases

scholarly journals Regional disease in head and neck cutaneous squamous cell carcinoma: the role of primary tumor characteristics and number of nodal metastases

2021 ◽  
Author(s):  
Alberto Grammatica ◽  
Michele Tomasoni ◽  
Milena Fior ◽  
Emanuela Ulaj ◽  
Tommaso Gualtieri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Multivariable Analysis ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Tumor Characteristics ◽  
Curative Intent

Abstract Purpose To identify potential risk factors impacting on overall survival (OS) of patients affected by lymph node metastasis from cutaneous squamous cell carcinoma (cSCC) of the head and neck (HN), with special emphasis on primary tumor characteristics and pattern of nodal recurrence (intraparotid and/or cervical). Methods A bi-institutional retrospective study on consecutive patients affected by cervical and/or intraparotid NM from HN cSCC and surgically treated with curative intent from May 2010 to January 2020 was conducted. OS was considered the outcome of interest. Results The study included 89 patients (M:F = 3.4:1; median age, 78 years; range, 22–99). Among the primary tumor characteristics, the most relevant prognostic factors were diameter ≥ 4 cm (hazard ratio [HR] = 2.56, p = 0.010) and depth of infiltration ≥ 6 mm (HR = 3.54, p = 0.027). Cervical NM was associated with worse OS (HR = 2.09, p = 0.016) compared to purely intraparotid NM (5-year OS: 60.9% vs. 28.1%, p = 0.014). At multivariable analysis, age, immunosuppression, pT3-T4 categories and a high burden of nodal disease (> 2 NM) confirmed to be independent risk factors, whereas adjuvant radiotherapy was independently associated with better outcome. Conclusion This study confirms the association of several independent prognosticators related to the patient, primary tumor, and nodal burden status. Patients with cervical NM should be considered at risk for harboring a higher number of metastatic lymph nodes.

scholarly journals Risk Factors and Diagnosis of Advanced Cutaneous Squamous Cell Carcinoma

2021 ◽  
Vol 11 (S2) ◽  
pp. e2021166S
Author(s):  
Gabriella Brancaccio ◽  
Maria Concetta Fargnoli ◽  
Giulia Briatico ◽  
Cristina Pellegrini ◽  
Tea Rocco ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Advanced Disease ◽  
Locally Advanced ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Tumor Diameter ◽  
Locally Advanced Disease

Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer affecting humans. The combination of the increasing incidence and high mortality in advanced stages of the disease, defines cSCC as an emerging public health problem. Advanced disease includes metastatic and locally advanced cSCC. Metastatic disease refers to the presence of locoregional metastasis (in transit or to regional lymph nodes) or distant metastasis. Locally advanced disease has been defined as non-metastatic cSCC that is unlikely to be cured with surgery, radiotherapy, or combination treatment. While metastatic cSCC is easily diagnosed, locally advanced disease lacks consensus definition and diagnosis is made after multidisciplinary board consultation. Identifying patients with aggressive cSCC at highest risk for relapse may prevent the occurrence of advanced disease. Prognostic factors suggested by most guidelines include tumor diameter (>2 cm), localization on temple/ear/lip/area, thickness (>6 mm), or invasion beyond subcutaneous fat, poor grade of differentiation, desmoplasia, perineural invasion, bone erosion, immunosuppression, undefined borders, recurrence, growth rate, site of prior radiotherapy, and lymphatic or vascular involvement. Although risk factors associated with worse outcomes are well known, there is still a gap of knowledge on the precise risk of each factor taken individually. The aim of this review is to summarize cSCC prognostic factors and encompass the various staging systems to guide management and follow-up in cSCC patients at higher risk for local recurrence and metastasis. Finally, we describe the hallmarks of the advanced disease. Advanced cSCC diagnosis should be made by a multidisciplinary board considering patients’ performance status and disease characteristics

Risk Factors and Mortality in Cutaneous Squamous Cell Carcinoma of the Head and Neck

2020 ◽  
Vol 111 (4) ◽  
pp. 325-328
Author(s):  
Á.J. Bernal Martínez ◽  
N. Fernández Letamendi ◽  
J. Delgado Martínez ◽  
J.M. Sampietro de Luis ◽  
L. Gómez-Escolar Larrañaga ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma
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